4 0 0 0 OA リポペプチド系抗真菌剤ミカファンギンの工業化
- 著者
- 大東 篤 渡辺 勝 椋田 隆司
- 出版者
- The Society of Synthetic Organic Chemistry, Japan
- 雑誌
- 有機合成化学協会誌 (ISSN:00379980)
- 巻号頁・発行日
- vol.64, no.12, pp.1294-1303, 2006-12-01 (Released:2010-10-20)
- 参考文献数
- 8
- 被引用文献数
- 1 2
The manufacturing process of Micafungin (1) which is a novel candin antifungal agent discovered and developed by Astellas Pharma Inc. was studied.A new asymmetric isoxazole ring formation which is key reaction for synthesis of side chain active ester 2 was developed via β-keto enamine intermediate.And also a reaction condition of selective acylation with FUN intermediate 3 and purification of Micafungin drug substance was investigated from the viewpoints of high quality and productivity.