著者

櫻又 康秀 大江 弘美 草野 崇一

出版者

和漢医薬学会

雑誌

和漢医薬学雑誌 (ISSN:18801447)

巻号頁・発行日

vol.21, no.5, pp.237-240, 2004-10-20

参考文献数

6

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Ludvik et al. have recently shown the effect of white skinned sweet potato (Ipomoea batatas L.) on reducing fasting blood glucose and insulin resistance in type-2 diabetic patients. It, however, was required 2-4 weeks after the starting of administration of white skinned sweet potato. The present study aimed to determine if the combination therapy of white skinned sweet potato with a loquat leaf extract, which shows an insulin-like effect, could make it possible to enhance the anti-diabetic activities of white skinned sweet potato, and to shorten the time necessary for the inhibition of increasing blood glucose levels. A mixture of the pulverized skin of white skinned sweet potato (194mg/kg) and the powdered loquat leaf extract (6mg/kg) was orally administered to 6 weeks-old male KK-Ay/Ta mice for 28 days and the glucose loading test was conducted every 7 days. In the glucose loading test after one week feeding, a reduction in blood glucose concentration after 60 minutes of the administration of glucose was observed in the mixture groups against the control group (p<0.05). In the case of white skinned sweet potato only, similar delayed effects were seen in 3 weeks after feeding.