著者

加藤 昌志 加藤 正史 大神 信孝 矢嶋 伊知朗

出版者

名古屋大学

雑誌

基盤研究(A)

巻号頁・発行日

2015-04-01

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本研医工連携研究では、まず、単波長の低周波音の曝露装置(低周波音刺激装置)を作製した。次に、実験研究により、低周波音が健康障害(平衡・運動機能障害)を誘発する閾値を提案するとともに、作用機序と内耳前庭にある標的部位(耳石・耳石膜)を特定した。また、内耳前庭の培養組織を用いて、迅速に低周波音の健康リスクを評価する技術を開発した。一方、疫学研究により、低周波音の健康影響をヒト(ヤングアダルト)で評価した。最後に、耳石膜のHeat Shock protein 70分子の発現を高めることで低周波音に由来する平衡・運動機能障害を予防できる可能性を、動物レベルで提案した。

著者

大神 信孝 押野 玲奈 二宮 裕将 李 香 加藤 昌志

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.72, no.1, pp.38-42, 2017 (Released:2017-02-02)

参考文献数

25

被引用文献数

1

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The inner ears contain the organ of Corti, vestibule and semicircular canal. The organ of Corti is crucial for hearing, while the vestibule and semicircular canal play important roles in maintaining balance. Exposure to noise at excessive levels is known to cause damages of the inner ears, resulting in noise-induced hearing loss. On the other hand, noise levels (dB) are used for the evaluation of health risks by exposure to noise, although noise consists of sound with broad frequencies (Hz). Thus, information about the frequency-dependent effect of noise on health is largely unknown. In this review, we first introduce noise-induced hearing loss caused by exposure to audible noise. We then describe the imbalance in mice exposed to low-frequency noise (100 Hz).

著者

大神 信孝 飯田 真智子 小又 尉広 中野 千尋 呉 雯婷 李 香 加藤 昌志

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.70, no.2, pp.100-104, 2015 (Released:2015-05-21)

参考文献数

24

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Noise stress generated in industry is one of the environmental factors that physically affects the functions of the inner ear. Exposure to noise can cause hearing loss, resulting in serious problems in occupational and daily life. At present, however, there are very limited ways to prevent hearing impairments. The inner ear consists of the organ of Corti, vestibule and semicircular canal. Functional or morphological damage of these tissues in the inner ear caused by genetic factors, aging or environmental factors can result in hearing or balance impairments. In this review, we first introduce a deafness-related molecule found by our clinical research. Our experimental research using genetically engineered mice further demonstrated that impaired activity of the target molecule caused congenital and age-related hearing loss with neurodegeneration of spiral ganglion neurons in the inner ears. We also describe impaired balance in mice caused by exposure to low-frequency noise under experimental conditions with indoor environmental monitoring. We believe that our approaches to pursue both experimental research and fieldwork research complementarily are crucial for the development of a method for prevention of impairments of the inner ear.