著者

並木 信重郎 神郡 邦男 長手 尊俊 杉田 和彦 原 寛 森 恵津子 大村 貞文 大関 正弘

出版者

The Japanese Society of Applied Glycoscience

雑誌

澱粉科学 (ISSN:00215406)

巻号頁・発行日

vol.27, no.2, pp.107-113, 1980-04-30 (Released:2010-06-28)

参考文献数

13

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TAI-A and TAI-B showed inhibitory activities against sucrase, maltase and isomaltase isolated from hog small intestine according to the method of Dahlqvist. TAI suppressed the increase of the blood glucose level of fasting mice administered with maltose. TAI suppressed the increase of the blood glucose level and the secretion of insulin of rats which were fasted and then forced-fed cooked corn starch, because of the inhibition against the starch digestion in the small intestine. The suppression of the increase in the body weight was observed in the 3 months toxicity test on the groups which were given diet containing 1.82 and 908 GIU/g of TAI, respectively . Hematological and histopathological examinations did not reveal any remarkable difference among all the experimental animals. TAI inhibited the growth of some anaerobic bacteria belonging to Clostridia, but did not show any inhibitory activity against other anaerobic bacteria. TAI and maltotriose showed an synergistic effect on the antibacterial activity.

著者

宮原 正 下條 貞友 豊原 敬三 今井 健郎 宮島 真之 本田 英比古 亀谷 雅洋 大関 正弘 小勝 順

出版者

The Japanese Society of Clinical Pharmacology and Therapeutics

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.16, no.2, pp.357-365, 1985-06-30 (Released:2011-02-25)

参考文献数

19

被引用文献数

4 4

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A phase I study of EST, a newly synthesized specific thiol protease inhibitor developed as a drug for muscular dystrophy, was performed in healthy adult male volunteers to investigate its safety and pharmacokinetics. EST was administered orally in single doses of 100 mg during fasting, or of 100 mg or 200 mg after a meal. The following results were obtained.The clinical tests and observation of the subjective and objective signs and symptomsfound no change due to EST.EST was detected as E-64-c (effective form of EST) in serum and urine after oral administration. The absorption of EST was slower when administered after a meal than during fasting. The AUC (area under the serum concentration curve) and urinary excretion rate were greater following administration after a meal, which indicates a tendency to better bioavailability of EST.As for the comparison of 100 mg and 200 mg administration after a meal, a distinct dosedependency was observed in the serum concentration and urinary excretion.