著者

熱海 明 青柳 澄 小野 精美 鈴木 武 鈴木 肇 栗原 幸一 西塚 胞喜 岡 英彦 二戸 源治 梅沢 長一 木村 広 安孫子 淳一 高梨 勝広 山口 正志 丹羽 与英 中村 春夫 高槻 和雄 遠藤 厳 岡田 昌吉 佐藤 幸雄 東海林 喜助 斯波 八郎 奥山 繁雄 五十嵐 茂 斎藤 安司 菊地 正逸 槙 千秋

出版者

公益社団法人 日本獣医師会

雑誌

日本獣医師会雑誌 (ISSN:04466454)

巻号頁・発行日

vol.17, no.10, pp.521-526,539, 1964-10-20 (Released:2011-06-17)

参考文献数

22

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A total of 244 persons were reported officially to be involved in an outbreak of food poisoning possibly attributed to whale-meat bacon in Yamagata and its neighboring areas in Yamagata Prefecture at the end of August. One fatal case occurred in the city of Yamagata.The period of incubation was 12 to 21 hours in most cases. The main symptoms consisted of fever, stomachache, vomiting, and diarrhea and were almost identical with those of food poisoning known to be caused by enteritis vibriones.The incriminated food was whale-meat bacon, which had been eaten without being cooked. The same food as this, in raw state, was given per os to mice and cats without any ill effect. Bacteriological examination failed to detect any known pathogenic organisms, except staphylococci, or such enteritis vibriones as identical with those of the known serotype.Enteritis vibrio O-2 (“E” by Agatsuma's classification) was detected from 19 (76%) of 25 fecal specimens collected from the patients involved. Staphylococcus and Proteus were also detected from these specimens. Most of the staphylococci isolated from the whale-meat bacon, and the fecal specimens were coagulase-positive.All the strains of enteritis vibriones isolated from the fecal specimens were pathogenic for mice. So were three strains of these organisms isolated from the whale-meat bacon.

著者

安孫子 淳

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.61, no.1, pp.24-34, 2003-01-01 (Released:2009-11-13)

参考文献数

14

被引用文献数

2 5

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Boron-mediated aldol reaction of carboxylic esters is described in detail. Contrary to the gener-al belief that carboxylic esters are inert toward the conventional enolization conditions, propionate esters are shqwn to have adequate reactivity on the boron-mediated aldol reaction. More impor-tantly, the stereochemical course of the aldol reaction can be controlled by the judicious choice of the enolization reagents. Complementary anti- and syn-selective asymmetric aldol reaction of structurally related chiral esters are developed. Also, novel double aldol reaction is discovered with acetate esters, which provides a precursor to the synthesis of chiral triols of C3-symmetry. Extensive NMR experiments lead to characterize the first carbon-bound boron enolates and the novel doubly borylate enolates as intermediates of the double aldol reaction. A plausible mecha-nism of the double aldol reaction is proposed.

著者

佐藤 恒夫 安孫子 淳 正宗 悟

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.44, no.5, pp.384-404, 1986-05-01 (Released:2010-04-23)

参考文献数

89

被引用文献数

2 2

著者

佐藤 恒夫 安孫子 淳 正宗 悟

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.44, no.4, pp.309-325, 1986-04-01 (Released:2010-01-22)

参考文献数

46

被引用文献数

2 5

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This account examines double asymmetric induction from theoretical and practical viewpoints. In the context of four major organic reactions-the aldol, Diels-Alder, catalytic hydrogenation, and epoxidation-it is shown that a double asymmetric induction can be analyzed in terms of the single asymmetric reactions of each of the two chiral reactants. A rule which qualitatively relates the results of these single asymmetric reactions with the outcome of the double asymmetric reaction is proposed. A powerful new strategy based on this rule for the predictable creation of new chiral centers is discussed and the use of this strategy for the synthesis of sugars and macrolides is presented.

著者

安孫子 淳

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.54, no.7, pp.564-573, 1996-07-01 (Released:2010-01-28)

参考文献数

28

被引用文献数

2 3

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New chiral auxiliaries based on the isoxazolidine skeleton have been developed. Characteristic feature of these auxiliaries are : 1) High reactivity for asymmetric alkylations. 2) Acylation of the auxiliary with an acid chloride and an amine, or DCC condensation. 3) One step transformation of the reaction products to the corresponding chiral alcohols, aldehydes and ketones without loss of the stereochemical integrity with the recovery of the auxiliary. Asymmetric alkylation of chiral β-substituted alkanols via their triflates lead to the easy access to the “reduced polypropionate units” as well as the first synthesis of the marine natural product (+) -siphonarienone. Enantiomerically pure axially dissymmetric cyclohexylidene compounds were synthesized using asymmetric Horner-Emmons reaction of the phosphonate derived from the auxilliary.