著者

宮地 隆興 大庭 雄三

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.15, no.3, pp.257-261, 1974

被引用文献数

1

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Fifteen abnormal hemoglobins which cause or may cause erythrocytosis are reviewed. Their clinical expression is a benign hereditary polycythemia which affects only erythrocytes. Abnormally high oxygen affinity of hemoglobin causes diminished oxygen supply to the tissue, and this in turn stimulates erythropoietin production by the kidneys resulting in increased erythropoiesis in the bone marrow. Hb Hiroshima is discussed first as a representative case, and the functional characteristics of such abnormal hemoglobins are explained in relation to their structural abnormality or a single amino acid substitution. Importance of blood oxygen affinity as a screening test for abnormal hemoglobin in erythrocytosis or anemia is stressed.

著者

宮地 隆興 大庭 雄三

出版者

Japanese Electrophoresis Society

雑誌

生物物理化学 (ISSN:00319082)

巻号頁・発行日

vol.23, no.2, pp.175-178, 1979-09-25 (Released:2009-03-31)

参考文献数

15