著者

寺岡 麗子 松田 芳久 杉本 功

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.521-529, 2002-12-10 (Released:2011-03-04)

参考文献数

9

被引用文献数

1 2

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Guanidine hydrochloride, which is known to be effective in the treatment of Lambert-Eaton myasthenic syndrome, is very hygroscopic. Therefore, the mixture of the drug and lactose dispensed at hospital pharmacies tends to easily liquefy even under ordinary storage conditions because of poor compatibility. In this study the physicochemical and chemical stabilities of commercially available guanidine salts, namely hydrochloride, nitrate, carbonate, and sulfate, were investigated at various relative humidity levels. The critical relative humidity of the hydrochloride salt was significantly lower than the others and it was also more hygroscopic than the other three salts, however, nitrate was found to be sufficiently stable regarding humidity. The powder maintained a good flowability after long storage periods. The optimal diluent was selected to use in powders consisting of guanidine hydrochloride in order to stabilize the physicochemical and chemical properties. No solidification or change in appearance were observed in the mixture of the drug and magnesium aluminometasilicate (Neusilin® US2) as diluent and moisture adsorbent. The flow property (angle of repose) of this mixture was also investigated.

著者

平井 みどり 八木 敬子 木口 敏子 長嶺 幸子 冨田 尚子 上田 久美子 平井 由華 加藤 史恵 寺岡 麗子 大塚 誠 岩川 精吾 松田 芳久

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.5, pp.461-467, 2002-10-10 (Released:2011-03-04)

参考文献数

5

被引用文献数

5 5

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Effective communication is central to patient-centered care in the successful practice of pharmacy. As well as communication skills, a pharmacist should acquire an effective presentation technique to establish interpersonal communication at a more than purely on a verbal level. Most undergraduates of Kobe Pharmaceutical University undergo practical training in hospitals or community pharmacies. It is essential for students to acquire communication skills in order to derive the full benefit from the practical training. We introduced a presentation and communication program at the pre-practical training stage. In the presentation component, students were asked to make a presentation on eight different aspects of a certain drug; in the communication component, students took part in a session where they learned and discussed interview skills, non-verbal communication, open-ended questioning and effective communication. Questionnaires answered by the undergraduates suggested that this training course had made a strong impression on them and had served as a useful guide to acquiring the presentation and communication skills essential in pharmaceutical care.