著者

川井 昂 松井 三雄 杉本 功介 吉本 俊明

出版者

一般社団法人 日本体育学会

雑誌

体育学研究 (ISSN:04846710)

巻号頁・発行日

vol.10, no.1, pp.249, 1965-06-10 (Released:2016-12-31)

著者

吉本 俊明 松井 三雄 吉田 清 平野 平三 鈴木 克也 杉本 功介 川中 昂 豊田 章 松田 岩男 太田 哲男 道明 弘章

出版者

一般社団法人 日本体育学会

雑誌

体育学研究 (ISSN:04846710)

巻号頁・発行日

vol.9, no.1, pp.405, 1964-06-10 (Released:2016-12-31)

著者

寺岡 麗子 松田 芳久 杉本 功

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.521-529, 2002-12-10 (Released:2011-03-04)

参考文献数

9

被引用文献数

1 2

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Guanidine hydrochloride, which is known to be effective in the treatment of Lambert-Eaton myasthenic syndrome, is very hygroscopic. Therefore, the mixture of the drug and lactose dispensed at hospital pharmacies tends to easily liquefy even under ordinary storage conditions because of poor compatibility. In this study the physicochemical and chemical stabilities of commercially available guanidine salts, namely hydrochloride, nitrate, carbonate, and sulfate, were investigated at various relative humidity levels. The critical relative humidity of the hydrochloride salt was significantly lower than the others and it was also more hygroscopic than the other three salts, however, nitrate was found to be sufficiently stable regarding humidity. The powder maintained a good flowability after long storage periods. The optimal diluent was selected to use in powders consisting of guanidine hydrochloride in order to stabilize the physicochemical and chemical properties. No solidification or change in appearance were observed in the mixture of the drug and magnesium aluminometasilicate (Neusilin® US2) as diluent and moisture adsorbent. The flow property (angle of repose) of this mixture was also investigated.

著者

粟田 則男 山本 恵一 中川 寛 杉本 功 坂田 英彦 佐藤 久

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.99, no.2, pp.141-145, 1979-02-25 (Released:2008-05-30)

参考文献数

11

被引用文献数

1 2

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Acebutolol hydrochloride was proved by thermal analysis (DTA and TG), IR spectra, and X-ray powder diffraction to have three crystalline forms (form I, II, and III) and an amorphous form. The amorphous form, which was stored at 20°under 91% R.H., was first transformed to forms II and III, and then it was finally transformed to form I. During this transformation, the incorporation and release of water were examined. Form I was stable at this condition, while form II was transformed to form I for 48 hr, and form III was transformed to form I for 2 hr. Further, it was found that the amorphous form was transformed to form II at 80°under 50% R.H. for 3 hr, but at 80°under vacuum it was transformed to form III. Form I at 138°for 8 hr and form III at 130°for 4 hr were transformed to form II. From these results it was concluded that form I was the most stable form at room temperature.