著者

赤木 博文 小坂 道也 福島 邦博 土井 彰 笹木 牧 小川 晃弘 西崎 和則 増田 游 松田 充浩 四方 賢一 槇野 博史 清水 順子 杉山 信義

出版者

日本口腔・咽頭科学会

雑誌

口腔・咽頭科 (ISSN:09175105)

巻号頁・発行日

vol.9, no.2, pp.253-260, 1997-02-28 (Released:2010-06-28)

参考文献数

26

被引用文献数

3

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口蓋扁桃摘出術を施行し, 6ヵ月以上経過観察できたIgA腎症47例を対象に, 治療成績と予後予測因子を検討し, 次の結果をえた.1. 扁摘後の最終観察時点での寛解率は, 尿蛋白61.7%, 尿潜血44.7%で, 尿蛋白・尿潜血ともに, 観察期間が長いほど低下傾向にあった.2. 腎病理組織所見の軽症例は, 重症例よりも尿蛋白の寛解率が高かった.3. 扁桃誘発試験陽1生例は, 陰性例よりも尿蛋白の寛解率が低かった.4. IgA腎症の発症年齢, IgA腎症発症から扁摘までの期間, Ccrは, 尿蛋白寛解例と非寛解例の間で有意差を認めなかった.

著者

小川 晃弘 岡野 光博 土井 彰 前田 幸英 西崎 和則 久保田 聡 古川 仭

出版者

Japan Rhinologic Society

雑誌

日本鼻科学会会誌 (ISSN:09109153)

巻号頁・発行日

vol.42, no.1, pp.23-27, 2003-04-01 (Released:2010-03-11)

参考文献数

11

被引用文献数

1 1

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Changes in the sense of smell may be quantitative and qualitative, or possibly even a combination. Quantitative changes may manifest themselves partly as hyperosmia and partly as hyposmia, although hyposmia is much more common. Qualitative changes are segignated a parosmia. Disosmia is a condition in which stimulation of the sense of smell does not result in an adequate olfactory impression, but rather in a distorted sensation, usually unpleasant. The precise mechanism and etiology of parosmia remain to be classified.Recent molecular biological advances enable us to a more accurately assess the prognosis for parosmia or suggest more successful treatment. We present an overview of modern classification or definition of parosmia and related clinical issues requiring greater discussion. We collected 94 parosmic patients from 9 dysosmia clinics and discussed them in this reports.Women over 40 years old are most susceptible to parosmia. Upper respiratory viral disease including common cold, head trauma and also zinc deficiency, are conditions that put patients at high risk for parosmia. About 6% of all patients seen at dysosmia clinics have parosmia. We classified parosmia patients by sites, etiology, and severity.Sites are usually the site of responsible for hyposmia or anosmia. Parosmia patients were divided into organic and functional. The organic type was divided into peripheral, central and mixed peripheral and central. The functional type includes the psychological disorder such as illusions of smell, olfactory hallucination, and the uncinates fits. Etiology was classified as sinonasal disease, upper respiratory disease, head injury, other or miscellaneous. Other categories includes zinc-deficient and drug-inducced. We classified severity as slight, moderate, or severe. Twelve factors, including gender, age, and duration, affect the prognosis of parosmia. We summed up the score for these factors and judged severity. For sever parosmic patients, medical treatment such as medication, local treatment, or surgery must be considered. Major tranquiraizer and surgery should be selected for patients with severe or intractable parosmia.