著者

田所 作太郎 栗原 嘉雄 栗原 憲雄 小川 治克 宮下 景司

出版者

The Kitakanto Medical Society

雑誌

北関東医学 (ISSN:00231908)

巻号頁・発行日

vol.12, no.4, pp.250-265, 1962 (Released:2009-11-11)

参考文献数

38

被引用文献数

2 2

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To define the standard for the normal physiological status of rats, about 300 Wistar strain rats, bred in our department, were examined for body weight gain with age in day, and weight of 11 organs-hypophysis, thyroid, adrenal, thymus, testis, ovary, uterus, heart, liver, spleen and kidney-were obtained for each body weight group. And the results were compared with Donaldson's report.As to body weight gain, our results approximately agreed with Donaldson's, but seemed rather lower as compared with recent growth curve for rats.As to correlation of body weight to weight of thymus, testis and ovary, our results tended to differ remarkably high in the latter. Weight of hypophysis and adrenal were evidently higher in females than in males, whereas those of thymus and kidney were conversely higher in male. In adrenal weight, there were remarkable differences between right and left side, the left exceeding the right without regard to sex.Female rats were examined for vagina opening and the first estrus, and from these results and organ weight increase, the puberty for sex was estimated to range 4575 days of age.Further, some discussions were made on whether it is reasonable to express the weight of the organ in ratio to body weight.

著者

小川 治克 田所 作太郎

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.68, no.5, pp.560-571, 1972

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Doxepin, one of tricyclic antidepressants was examined as to whether or not it possesses a diazepam-like effect. Water-deprived rats were tested in an apparatus where they drank water under two kinds of conflict schedules.<br> A clear diazepam-like effect was observed after long term administration of doxepin in the approach-withdrawal conflict schedule, although the potency was weaker than that of diazepam. In approach-avoidance conflict schedule a slight effect only was exhibited after doxepin.<br> No marked sign was detected in the experiments after withdrawal of daily administration of doxepin.