著者

田所 作太郎

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.8, no.3, pp.347-355, 1977-09-30 (Released:2010-06-28)

参考文献数

54

被引用文献数

1 1

著者

田所 作太郎 栗原 久

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.95, no.5, pp.229-238, 1990 (Released:2007-02-20)

参考文献数

52

被引用文献数

24 25

---

It has been well-known that a chronic abuse of amphetamines induces schizophrenia-like psychotic symptoms, namely amphetamine psychosis. When amphetamines are repeatedly administered to rodents, a reverse tolerance (behavioral sensitization) to the ambulationincreasing and/or stereotypy-producing effect is observed. The process of the reverse tolerance is affected by various factors. A clear reverse tolerance is produced when optimal doses of the drug (2 mg/kg, s.c. for mice, and 0.5 ?? 1 mg/kg, s.c., for rats) is administered at intervals of longer than 1 day rather than a shorter interval. Furthermore, the animal has to be put into a freely mobile situation during the presence of the acute drug effect. A cross reverse tolerance is observed between certain types of drugs that show an ambulation-increasing effect, although the potencies are different among the drugs. A reverse tolerance to the stereotypy (in particular sniffing and head-bobbing)producing effect is also observed when comparatively higher doses of methamphetamine are repeatedly administered. The process is qualitatively identical with the reverse tolerance to the ambulation-increasing effect produced by the repeated administration of comparatively smaller doses. The reverse-tolerance, once established, to both ambulation-increasing and stereotypy-producing effects is almost irreversible even with various treatments such as repeated post-treatment with antipsychotics. The characteristics of reverse tolerance to methamphetamine in animals might be closely correlated to the amphetamine psychosis in humans. It is also necessary to search for a method that effectively reduces the established reverse tolerance to amphetamines.

著者

田所 作太郎

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.11, no.11, pp.735-742, 1973

被引用文献数

1

著者

田所 作太郎 栗原 嘉雄 栗原 憲雄 小川 治克 宮下 景司

出版者

The Kitakanto Medical Society

雑誌

北関東医学 (ISSN:00231908)

巻号頁・発行日

vol.12, no.4, pp.250-265, 1962 (Released:2009-11-11)

参考文献数

38

被引用文献数

2 2

---

To define the standard for the normal physiological status of rats, about 300 Wistar strain rats, bred in our department, were examined for body weight gain with age in day, and weight of 11 organs-hypophysis, thyroid, adrenal, thymus, testis, ovary, uterus, heart, liver, spleen and kidney-were obtained for each body weight group. And the results were compared with Donaldson's report.As to body weight gain, our results approximately agreed with Donaldson's, but seemed rather lower as compared with recent growth curve for rats.As to correlation of body weight to weight of thymus, testis and ovary, our results tended to differ remarkably high in the latter. Weight of hypophysis and adrenal were evidently higher in females than in males, whereas those of thymus and kidney were conversely higher in male. In adrenal weight, there were remarkable differences between right and left side, the left exceeding the right without regard to sex.Female rats were examined for vagina opening and the first estrus, and from these results and organ weight increase, the puberty for sex was estimated to range 4575 days of age.Further, some discussions were made on whether it is reasonable to express the weight of the organ in ratio to body weight.

著者

田所 作太郎

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.11, no.11, pp.735-742, 1973-11-25 (Released:2009-05-25)

参考文献数

10

被引用文献数

1 1

著者

田所 作太郎

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.24, no.10, pp.1013-1017, 1988-10-01 (Released:2018-08-26)

著者

小川 治克 田所 作太郎

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.68, no.5, pp.560-571, 1972

---

Doxepin, one of tricyclic antidepressants was examined as to whether or not it possesses a diazepam-like effect. Water-deprived rats were tested in an apparatus where they drank water under two kinds of conflict schedules.<br> A clear diazepam-like effect was observed after long term administration of doxepin in the approach-withdrawal conflict schedule, although the potency was weaker than that of diazepam. In approach-avoidance conflict schedule a slight effect only was exhibited after doxepin.<br> No marked sign was detected in the experiments after withdrawal of daily administration of doxepin.