1 0 0 0 OA ネダプラチンのNa+, K+-ATPase活性阻害とヒト賢由来近位尿細管細胞に対する作用
- 著者
- 山下 知巳 鈴木 邦明 出山 義昭 山岡 真茂 北田 秀昭 福田 博
- 出版者
- JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
- 雑誌
- 歯科薬物療法 (ISSN:02881012)
- 巻号頁・発行日
- vol.21, no.1, pp.4-12, 2002-04-01 (Released:2010-06-08)
- 参考文献数
- 19
Nedaplatin (NDP), an anticancer platinum complex, is supposed to have stronger action on malignant tumor and less nephrotoxicity than cisplatin. As details of the nephrotoxicity of NDP are not known, we studied the effect of NDP on pig kidney Na+, K+-ATPase activity and human renal proximal tubule epithelial cells (HRPTE cells) . The pig kidney Na+, K+-ATPase activity was inhibited by NDP, and the inhibition depended on the incubation time and the concentration of NDP, and the activity was recovered by sulfides. NDP decreased Na+, K+-ATPase and acid phosphatase activities of HRPTE cells, and the decrease was partially inhibited by addition of 2-mercaptoethanol (2ME) . HRPTE cell death by apoptosis was observed in the presence of NDP, and it was also partially inhibited by 2ME. These results suggest that the inhibition of enzyme activities by NDP may be related to nephrotoxicity, and that some sulfides can recover the activities and may reduce nephrotoxicity.
1 0 0 0 舌紡錘細胞癌の臨床病理学的検討
1 0 0 0 顎下腺と副耳下腺に発生した良性リンパ上皮性疾患の 1 例
- 著者
- 小村 健 嶋田 文之 奥村 一彦 柳井 智恵 山下 知巳
- 出版者
- Japanese Society of Oral and Maxillofacial Surgeons
- 雑誌
- 日本口腔外科学会雑誌 (ISSN:00215163)
- 巻号頁・発行日
- vol.43, no.5, pp.410-412, 1997-05-20
- 被引用文献数
- 2
A 58-year-old man with benign lympohoepithelial lesions in the right submandibular and accessory parotid glands is reported.<BR>The patient had no signs or symptoms other than tumors in the right submandibular and accessory parotid glands. He underwent removal of the tumors under the diagnosis of a submandibular gland tumor with cheek tumors. Histological examination of the surgical specimens revealed loss of acinar tissue with lymphocytic cell infiltration. Lymphoid follicles and epimyoepithelial islands were also found in the lymphoid tissues, but no neoplastic changes were evident in the specimens. Based on these findings, all tumors were histopathologically diagnosed as benign lymphoepithelial lesions.<BR>There has been no evidence of recurrence or other systemic diseases as of 34 months after surgery.