著者

岡本 緩子

出版者

関西医科大学医学会

雑誌

大阪女子医科大学雑誌 (ISSN:21864926)

巻号頁・発行日

vol.7, no.1-3, pp.41-45, 1955-03-20 (Released:2013-02-19)

参考文献数

9

著者

大久保 進 藤井 康英 岡本 緩子 大久保 滉

出版者

関西医科大学医学会

雑誌

関西医科大学雑誌 (ISSN:00228400)

巻号頁・発行日

vol.33, no.1, pp.47-54, 1981-03-20 (Released:2013-02-19)

参考文献数

22

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I. A 26 years old woman, complainig of general malaise and hypermenorrhea was admitted to our hospital in Feb.,1978. She had been suspected of idiopathic thrombocytopenic purpura (ITP) by her home doctor.Laboratory examin ations (Tab.1, Fig.1) revealed thrombocytopenia (26,000/cmm) and abnormal immuno-serological findings, including LE phenomenon (+), LE test (+), DNA test (×640), ANA (×160), BFP (+), RAT ( + ), Coombs test D (+) and hypergammaglobu linemia (1.84-1.36g/di). Her bone marrow picture was typical of ITP, i. e. an increased count in megakaryocytes lacking platelet production.Clinically, the patient showed slig ht fever and sometimes complained of bilateral knee joint Pain.She was diagnosed as SLE, chiefly manifesting thrombocytopenia, and was treated with corticoid (prednisolone), resulting in an improved platelet count (253,000/cmm) in three weeks.II. This case drew our attention to the relationship between ITP and SLE, which led us to investigate the autoantibodies in ten cases of ITP (Tab.2, Figs.2,3) treated at our department during the last five years.1) The positive rates o f the immuno-serological tests in our ITP cases were as follows: Anti-platelet antibody 1/7, LE phenom.0/6, LE test 0/9, DNA test 3/6, ANA 2/9, Microsome test 4/9, Thyroid test 4/9, RAT 4/8, BFP 4/8 and Coombs test 2/4 (Figs.4,5). Comparing these data with those of the SLE cases reported in the literature (Fig.4), some differences suspected to exist between the immunological failure in ITP and that in SLE.2) In all the four ITP cases responding well to corticoid therapy, the BFP was positive: in the non-responding cases, it was negative.In each case, little correlation could be seen between the number of positive tests and response to therapy.The han dling. of ITP cases necessitates a follow up in which attention is paid to the possible concomitance or succession of other auto-immune diseases.An accumulation of case studies in this direction may reveal the pathogenic correlations between ITP and SLE or other auto-immune diseases.

著者

大久保 滉 岡本 緩子 呉 京修 右馬 文彦 上田 良弘 前原 敬悟 牧野 純子

出版者

Japanese Society of Chemotherapy

雑誌

CHEMOTHERAPY (ISSN:00093165)

巻号頁・発行日

vol.26, no.1, pp.337-345, 1978

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Cefoxitin, an antibiotic developed from the cephamycin family, was examined as to its <I>in vitro</I> activity against clinically isolated bacteria, its serum level and urinary excretion after intramuscular or intravenous injection, tissue concentration in rats as well as its effectiveness in clinical cases. The results obtained were as follows:<BR>1) Antibacterial activity: Cefoxitin (CFX) was found to be more active against most of <I>E. coli, Klebsiella</I> and <I>Proteus vulgaris</I> strains than cephalothin and cephaloridine. The MICs of CFX against those bacteria were lowered when the inoculum concentration was reduced to 10<SUP>6</SUP> cell/ml.<BR>2) Serum level and urinary excretion in human: The drug showed a serum peak level as high as 148μg/ml 30 minutes after 1μg/ml injection, followed by a steep decline. The urinary excretion rate was about 80%.<BR>3) Distribution into rat organs: The highest tissue concentration of CFX in rat organs after i.m. administration was found in kidneys, followed by liver, blood, lungs, muscles and spleen. This distribution pattern was similar to that of cefazolin, though CFX showed higher peak concentrations and a steeper decline than the latter. No remarkable inactivation of CFX was observed after overnight storage in the icebox mixed with rat organ homogenates.<BR>4) Clinical trials: Six clinical cases (pneumonia, sepsis, purulent arthritis, perityphlitis, pyelonephritis and fever of unknown origin all of them having underlying diseases) were treated with CFX intravenously or by drip infusion. All of the patients responded favorably to the treatment. No side effects were observed.

著者

大久保 滉 岡本 緩子 呉 京修 右馬 文彦 上田 良弘 前原 敬悟 牧野 純子

出版者

Japanese Society of Chemotherapy

雑誌

CHEMOTHERAPY (ISSN:00093165)

巻号頁・発行日

vol.27, no.5, pp.260-271, 1979

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新Cephalosporin系抗生物質であるCefamandoleについて基礎的・臨床的検討を行なった。<BR>CefamandoleはCEZ, CFX, CET, CERなど他のCephalosporin系抗生剤と比べて, <I>E. coli. Proteus mimbilis</I>に対し特に優れめ抗菌力を示し, ラットでの臓器内不活性化も少なく, 十分な臓器内濃度, 胆汁中排泄が得られた。<BR>Cefamandoleの1回1~2gを1日2~3回点滴あるいは静注で臨床例8例 (肺炎2例, 胆道感染2例, 尿路感染2例。副鼻腔炎1例, 腹膜炎1例) に使用し, 効果不明例および不適当例を除くと6例中4例に有効 (有効率67%) であった。副作用ないし臨床検査異常値としては好酸球増多 (1%-11%) 1例のみであった。