著者

工藤 龍彦 首藤 裕

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.7, no.3, pp.239-243, 1996-06-01 (Released:2010-08-05)

参考文献数

10

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Patients on oral anticoagulant therapy present a clinical problem when they take large amounts of natto, because immoderate ingestion of natto results in reduction of the effect of warfarin so that thrombotest and PT-INR are adversely affected.We previously demonstrated an undesirable effect of immoderate ingestion of natto in a trial in patients given 100g of natto each. In the present study changes in blood levels of vitamins K were determined after the administration of reduced doses of 10 and 30g of natto.There was no change in blood levels of MK-4. Howevere, the blood levels of vitamin K1 increased from 0.53±0.26ng/ml to 0.72±0.25ng/ml at 4 hours after the administration of 10g of natto (p<0.001). After the administration of 30g of natto the blood level of vitamin K1 increased from 0.46±0.28ng/ml to 0.70±0.21ng/ml at 4 hours (p<0.001). The blood level of MK-7 increased from 0.58±0.15ng/ml to 2.43±0.77ng/ml at 4 hours, 1.66±0.69ng/ml at 24 hours, and 1.28±0.46ng/ml at 48 hours after the administration of 10g of natto (p<0.001).After the administration of 30g of natto the blood level of MK-7 increased from 0.57±0.18ng/ml to 7.24±2.92, 4.53±1.82, and 3.00±1.09ng/ml at the same time points as mentioned above, respectively (p<0.001).The results of this study suggest the wisdom of discouraging patients on anticoagulant therapy from taking natto, since it may reduce the effect of warfarin, be the amount ingested 30g or 10g insted of 100g.

著者

工藤 龍彦 内堀 陽二 渥美 和彦 沼尾 嘉時 川守田 英夫 三浦 勇 設楽 正登 北村 信夫 石井 潔 橋本 明政

出版者

公益財団法人 日本心臓財団

雑誌

心臓 (ISSN:05864488)

巻号頁・発行日

vol.10, no.6, pp.595-598, 1978-06-01 (Released:2013-05-24)

参考文献数

11

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われわれは,弁置換術後で抗凝血(薬)療法を実施中の患者が,納豆を摂取したのちThromb-test値が有意に上昇する現象を経験した.ヒトと家兎による裏付け実験で,日常食品である納豆に,強力なWarfarin拮抗作用を認めた.納豆が有するWarfarin拮抗作用は,納豆菌が腸内で多量のビタミンKを合成するためと推定した.抗凝血療法のポイントは,TT値を長期間,一定の治療域内に維持することにある.したがって,Warfarin投与患者に対しては,TT値に影響を及ぼす納豆を要注意食品として指導する必要があると考えた.