著者

立川 敬子 平 健人 岡田 常司 宗像 源博 眞坂 こづえ 塩田 真 春日井 昇平

出版者

口腔病学会

雑誌

口腔病学会雑誌 (ISSN:03009149)

巻号頁・発行日

vol.70, no.3, pp.182-189, 2003-09-30 (Released:2010-10-08)

参考文献数

18

被引用文献数

1 3

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The clinical analysis of 462 patients (154 men and 308 women) with problems of implant therapy done at other clinics is reported. They visited the clinic for oral implant of the Tokyo Medical and Dental University Hospital during the period from January 1996 to March 2002. The results were as follows1) The majority of the patients (76.6%) were 40 to 69 years of age.2) Of the total patients, 26.8% had been referred from the other outpatient clinics in our hospital, 14.7% from private dental offices and 2.6% from attending doctors.3) There were 361 patients with complications related to the implant therapy. Seventy-six patients asked for second opinions concerned about a diagnosis or treatment recommendation. Thirty patients required maintenance of the implants.4) The most common complications observed were peni-implantitis (184 cases) . Prosthodontic compli-cations (72 cases) included framework/resin/veneering material fractures, screw loosening and fractures. There were implant fractures in 21 cases, sensory disturbance in 20 cases, problems related to sinus in 13 cases, problems of connected teeth in 30 cases and phonetic/esthetic complications in 10 cases.5) The types of problem implants were osseointegrated implants (196 cases), alumina-ceramic implants (74 cases), metallic blade type implants (35 cases), pin type implants (10 cases), subperiosteal implants (6 cases) and other implants.

著者

春日井 昇平

出版者

日本再生歯科医学会

雑誌

日本再生歯科医学会誌 (ISSN:13489615)

巻号頁・発行日

vol.1, no.1, pp.3-11, 2003 (Released:2005-06-03)

参考文献数

18

被引用文献数

2

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歯科では口腔組織の欠損部を材料により補填し, 機能を回復する治療法がおこなわれている. 一方, 喪失あるいは機能の低下した組織や臓器を再生する再生医療が注目されている. 1920年にHermannが水酸化カルシウムを断髄面に使用したのが歯科領域での再生医療の始まりとされている. その後, 1980年代になってGTR法とGBR法が報告され, 1990年代に入って仮骨延長法の口腔領域での適用がおこなわれた. 1990年代の後半には, Emdogainによる歯周組織の再生, rhBMPによる骨増加法, PRPによる骨増加法についての臨床報告がなされた. 現在FGF2の歯周組織の再生への効果について臨床試験がおこなわれている. 一方, 歯科領域での細胞を用いた再生治療として, 粘膜の再生, 顎骨の再生, 歯周組織の再生が試みられており, さらに歯の再生プロジェクトも開始されている. 再生医療が社会に受け入れられるためには確実な治療効果と共に, 安全性と簡便性さらに経済的な利点も要求されると考えられる.

著者

春日井 昇平

出版者

一般社団法人 日本炎症・再生医学会

雑誌

炎症・再生 (ISSN:13468022)

巻号頁・発行日

vol.23, no.1, pp.34-38, 2003 (Released:2006-12-01)

参考文献数

14

被引用文献数

4 3

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Periodontal ligament (PDL) is a thin non-mineralized connective tissue between two mineralized tissues: alveolar bone and cementum. PDL keeps its function under enormous mechanical stress. In this article, I will introduce our studies characterizing the uniqueness of PDL and then discuss regeneration of periodontal tissue. S100A4 is a small Ca binding protein and we found high expression level of S100A4 in PDL. Histologically S100A4 localized on extracellular matrix and analysis of culture medium of PDL fibroblasts revealed secretion of S100A4 and recombinant S100A4 protein inhibited mineralization of osteoblastic culture. MC3T3-E1 cells (mouse osteoblastic cell line) expressed S100A4 at very low level and inhibition of S100A4 with a retroviral vector containing S100A4 antisense enhanced the mineralization of MC3T3-E1 cell culture. Finally, when PDL cells were exposed under mechanical stress in culture, expression level of S100A4 increased. These results indicate that S100A4 acts as a mineralization inhibitor in PDL and also bone; and that this protein plays a role in keeping its function under enormous mechanical stress. Although PDL is a non-mineralized tissue, it contains progenitors of osteoblasts and cementoblasts. Indeed, PDL is prerequisite for periodontal tissue regeneration. Application of guided tissue regeneration (GTR) and/or enamel matrix derivative (EMDOGAIN) promote periodontal tissue regeneration. Treatment with a dental implant, which is inserted to edentulous bone, is clinically acceptptable; however, a dental implant with PDL like a natural tooth would be more ideal.

著者

湯川 健 立川 敬子 宗像 源博 塩田 真 春日井 昇平

出版者

公益社団法人 日本口腔インプラント学会

雑誌

日本口腔インプラント学会誌 (ISSN:09146695)

巻号頁・発行日

vol.27, no.2, pp.175-180, 2014-06-30 (Released:2014-07-25)

参考文献数

15

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A questionnaire survey was conducted to determine the information required by patients prior to providing informed consent for dental implant surgery. Questionnaires were distributed to 1,585 patients who visited the Tokyo Medical and Dental University Hospital for oral implants between January 2012 and December 2012, of which 1,159 (73%) valid questionnaires were collected. The results showed that preservation of an adjacent tooth was the reason that 32% of participants chose implant therapy. Over 70% of participants indicated that their main concerns regarding implant therapy were aftereffects of surgery, the number of years the implants would be in place, and treatment cost. Regarding knowledge about implant therapy, patients' most frequent reply was“ I do not know” when asked about postoperative pain, peri-implantitis, the importance of implant maintenance, and the relationship between general health and implant therapy. Fifty-nine percent of the patients recognized smoking as a risk factor for periodontal disease, of which 23% recognized smoking as a risk factor for implant therapy. Sixty-one percent of patients replied“ more than 20 years” when asked about the number of years that they believed the implants would be in place. This research identified the information required by patients in order to provide informed consent. Comprehensive information is required before informed consent is sought, as the majority of patients did not possess sufficient knowledge regarding implant therapy.

著者

宗像 源博 塩田 真 誉田 栄一 立川 敬子 春日井 昇平 倉林 亨

出版者

公益社団法人 日本口腔インプラント学会

雑誌

日本口腔インプラント学会誌 (ISSN:09146695)

巻号頁・発行日

vol.17, no.2, pp.196-201, 2004-06-30 (Released:2015-02-10)

参考文献数

19

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Evaluation of jawbone quality is very important for successful implant treatment; however, a method to evaluate bone quality of the jaw has not been established. Furthermore, at present, bone classifications are relatively rough and subjective methods for pre-operative assessment. This study compared the buccal and the lingual cortical bone mineral densities (BMD), and correlation trabecular BNID and cortical BMD by quantitative computed tomography (QCT). The subjects were 56 patients with mandibular distal extension defect (20 males, 17 pre-menopausal and 19 post-menopausal women;age range 30 to 79 years). The buccal and lingual cortical BMD and the trabecular BMD were measured by QCT. The difference and the correlation among the three groups were estimated. The results were as follows. 1. The buccal cortical BMD was significantly higher than the lingual cortical BMD in the male and pre-menopausal group. However, no significant difference was seen between the buccal and the lingual cortical BMD in the post-menopausal group. 2. The buccal cortical BMD correlated well with the trabecular BMD in the male group. 3. The buccal and the lingual cortical BMD did not correlate with the trabecular BMD in the pre-menopausal group. 4. The buccal cortical BMD correlated significantly with the trabecular BMD in the post-menopausal group. In conclusion, it is important to consider these tendencies of mandibular BMD in dental implant treatment.