文献一覧: 横山和人 (著者)

1 0 0 0 OA すでに血中濃度未検出であったアセトアミノフェン中毒による急性肝不全の1例

著者: 金子唯池尻薫家城洋平横山和人川本英嗣石倉健今井寛
出版者: 一般社団法人日本中毒学会
雑誌: 中毒研究 (ISSN:09143777)
巻号頁・発行日: vol.35, no.4, pp.325-328, 2022-12-10 (Released:2023-01-26)
参考文献数: 4

Acetaminophen overdose results in acute liver damage. Measurement of the plasma concentration and a nomogram identify patients who require hepatoprotective treatments. The patient was a 28-year-old woman who ingested 100-200 pills of 200-mg acetaminophen and was found unconscious at home. She was brought to the emergency room and subsequently referred to our hospital 4 days later. The plasma concentration of acetaminophen could not be measured. However, she showed signs of acute liver failure and hepatic encephalopathy, and was treated with N-acetylcysteine (NAC) to treat liver failure. She also required plasma exchange with continuous hemodiafiltration. Treatments were successful in improving her consciousness impairment, and she was discharged on day 9. Although the plasma concentration of acetaminophen could not be measured, it was not necessary for determining the diagnosis and treatment plans.