著者

漆崎 文男 山口 洋 水町 浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.106, no.6, pp.491-497, 1986-06-25 (Released:2011-01-31)

参考文献数

9

被引用文献数

1 7

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Polyvinyl alcohol (PVA) aqueous solutions with high water content were repeatedly frozen and defrosted to obtain PVA hydrogels with high elasticity.Tack and viscoelasticities such as storage modulus and loss tangent of the PVA hydrogels were determined as a function of molecular weight, saponification value of PVA, number of cycles of freezing-defrosting procedure or temperature of defrosting, in order to obtain an information on utilities of the materials as prepared poultices and transdermal therapeutic system.Correlation matrix method of multiregression analysis was applied to our data on tack and viscoelasticities of gels, and it was found that there was a significant correlation between tack and storage modulus as well as loss tangent of the materials.Tack, which is one of the most essential properties of pressure sensitive adhesives as prepared poultices and drug delivery system, can easily be predicted, if we measure viscoelasticities of the materials.