- 著者
- 安茂 寿夫 和志 武三徳 漆崎 文男 野田 国男
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- 藥學雜誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.88, no.11, pp.1404-1411, 1968
2, 2-Diphenyl-2-propargyloxyacetic acid (2-dimethylaminoethyl) ester hydrochloride (DPDM) is decomposed in aqueous solution. It was confirmed by thin-layer chromatography and gas chromatography that the decomposition of DPDM occurs as consecutive reactions. In the first step, DPDM is hydrolysed to propargyloxy-benzilic acid (BPE) and β-dimethylaminoethanol hydrochloride and next, BPE is decomposed to benzilic acid (BA) and propargyl alcohol. As BPE is extremely slightly soluble in water, BPE precipitates in aqueous solution in proportion to decomposition of DPDM. In the present investigation, the hydrolytic decomposition of DPDM and BPE was studied in order to obtain more stable aqueous preparations, and DPDM was found to be stable at pH 2.5 to 3.5. Variations in the concentration of DPDM, BPE, and BA in aqueous solution were calculated by an analog computer. Data observed in the experiment corresponded with those calculated by the computer.
1 0 0 0 OA ポリビニルアルコール水溶液ゲルの粘着性と粘弾性
- 著者
- 漆崎 文男 山口 洋 水町 浩
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.106, no.6, pp.491-497, 1986-06-25 (Released:2011-01-31)
- 参考文献数
- 9
- 被引用文献数
- 1 7
Polyvinyl alcohol (PVA) aqueous solutions with high water content were repeatedly frozen and defrosted to obtain PVA hydrogels with high elasticity.Tack and viscoelasticities such as storage modulus and loss tangent of the PVA hydrogels were determined as a function of molecular weight, saponification value of PVA, number of cycles of freezing-defrosting procedure or temperature of defrosting, in order to obtain an information on utilities of the materials as prepared poultices and transdermal therapeutic system.Correlation matrix method of multiregression analysis was applied to our data on tack and viscoelasticities of gels, and it was found that there was a significant correlation between tack and storage modulus as well as loss tangent of the materials.Tack, which is one of the most essential properties of pressure sensitive adhesives as prepared poultices and drug delivery system, can easily be predicted, if we measure viscoelasticities of the materials.