著者

水谷 弘

出版者

日本蘇生学会

雑誌

蘇生 (ISSN:02884348)

巻号頁・発行日

vol.13, pp.56-62, 1995-04-20 (Released:2010-06-08)

著者

水谷 弘

出版者

一般社団法人 ターボ機械協会

雑誌

ターボ機械 (ISSN:03858839)

巻号頁・発行日

vol.6, no.3, pp.143-151, 1978-03-10 (Released:2011-07-11)

参考文献数

8

著者

渡辺 大一 福谷 俊 伊川 博 山浦 哲明 加瀬 則子 水谷 弘子

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.34, no.11, pp.4855-4858, 1986-11-25 (Released:2008-03-31)

参考文献数

8

被引用文献数

2 2

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Two crystal forms of the new dihydropyridine derivative, methyl (E)-3-phenyl-2-propen-1-yl 1, 4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)pyridine-3, 5-dicarboxylate (FRC-8411), were obtained by recrystallization from methanol. These crystal forms were identified by using powder X-ray diffractometry, infrared spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry. By means of DSC, the melting points of forms I and II were found to be 140 and 121°C, respectively.Forms I and II, having a similar particle size distribution, were administered orally or intravenously to spontaneously hypertensive rats. In the case of oral administration, the hypotensive action of form I was milder than that of form II and tachycardia was not observed after administration of form I.