- 著者
-
深井 原
藤堂 省
- 出版者
- 一般社団法人 日本臓器保存生物医学会
- 雑誌
- Organ Biology (ISSN:13405152)
- 巻号頁・発行日
- vol.18, no.1, pp.92-98, 2011-06-10 (Released:2014-11-26)
- 参考文献数
- 19
Heavy water, deuterium oxide(D2O), is a stable isotope compound of H2O, causing stabilization of actin and tubulin. D2O inhibits cytosolic calcium overload via plasma membrane channel and ER. D2O stimulates ATP production by augmenting glucose uptake, activities of glycolysis, TCAcylcle, and oxidative phosphorylation in certain experimental models. Further, D2O inhibits organ swelling and damage during cold preservation. Although precise mechanism remains unclear, these properties are considered suitable for the organ preservation. Here we reviewed the possible cytoprotective actions of D2O from the biophysical, biochemical, and clinical viewpoints to enlighten the new insight of organ preservation.