2 0 0 0 OA 自壊乳がん巨大腫瘍におけるMohs’ペースト止血症例と薬理学的作用機序の解明
- 著者
- 出雲 信夫 重山 昌人 田口 真穂 長嶋 大地 長野 将大 菊池 絵里 橋口 宏司 藤澤 順 村田 実希郎 礒部 隆史 梶原 康宏 五十鈴川 和人 埴岡 伸光 渡邉 泰雄 寺町 ひとみ
- 出版者
- 一般社団法人日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.42, no.4, pp.246-254, 2016-04-10 (Released:2017-04-10)
- 参考文献数
- 10
- 被引用文献数
- 4 3
Massive bleeding induced by disintegration of breast cancer tumors for 4 yrs (88 yrs-old lady) was treated by applying Mohs' paste (75g/45mL of Zinc complex). This huge site healed quickly and the healing effects were sustained for 48 days. Based on this clinical evidence, the hemostatic mechanism of Mohs' paste was evaluated using the hind limb ischemia model in mice. Unilateral hind limb ischemia was induced in 6 week-old male C57BL/6JJmsSlc mice by resecting the right femoral and saphenous arteries. Mice were painted once a day with Mohs' paste containing 0, 37.5, 50 and 62.5g/45mL of zinc after the surgery. Hind limb blood perfusion was measured by using a laser Doppler perfusion imaging system (moorLDI2-Ⅱλ : S/N 5489). To identify capillaries, the thigh muscles were harvested on Day 1 to make a tissue section and immunostained for CD31. One day after painting of Mohs' paste, blood flow suppression to the ischemic leg was significantly enhanced in a dose dependent manner. Furthermore, anti-CD31 immunostaining revealed that Mohs' paste decreased capillary density in the ischemic muscle. The results of both the clinical and animal studies suggest that Mohs' paste suppressed angiogenesis due to the acute effects of aggregated protein and the sustained effects of decreases of CD31.
1 0 0 0 OA バナジウム含有天然水の糖尿病改善作用における考察
- 著者
- 渋市 郁雄 安江 正明 加藤 克彦 渡邉 泰雄
- 出版者
- 日本微量元素学会
- 雑誌
- Biomedical Research on Trace Elements (ISSN:0916717X)
- 巻号頁・発行日
- vol.17, no.1, pp.11-16, 2006 (Released:2006-09-13)
- 参考文献数
- 24
- 被引用文献数
- 1
This paper argues the possible effects of natural vanadium-containing Mt. Fuji ground water on the hyperglycemia based on our previously reported animal and clinical studies. In the animal studies, we documented that the activities of liver insulin receptors, particularly β subunit, and primary insulin-like growth factor-1 β were recovered to the normal levels by the daily forced oral treatment with Mt. Fuji ground water containing natural vanadium in Goto-Kakisaki (GK) rat which is the genetic model of Type II diabetes. Furthermore the increased levels of blood glucose and serum hemoglobin A1C (HbA1C) of GK rats were significantly blocked by the consecutive treatment of natural vanadium water. It is interesting that the other genetic model of Type II diabetes, KKAy mice, were likely to be shown the inhibitory effects of the consecutive treatment of natural vanadium water on increases of blood glucose but not significant. In these animals, however, the significant improvements of Glut 4 transporter and receptor activities in the adipose and muscle were detected. In the clinical studies, the levels of blood glucose and serum HbA1C of hyperglycemic patients were significantly reduced by three month consecutive treatment of this Mt. Fuji ground water, and also the QOL of these patients were completely improved, although these effects were clearly affected by the changes in each life style. Thus both animal and human studies suggest that the daily treatment with Mt. Fuji ground water containing natural vanadium is useful for the regulation of blood glucose levels and the improvement of QOL to the hyperglycemia patients due to the improvements of glucose transporter and the insulin receptor and so on. However it might be little difficult to expect the significant improvement of the severe conditions of diabetes mellitus by the consecutive treatment of natural vanadium water, since this ground water is good as a supplement.