著者

前田 美穂

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.1, pp.19-24, 2005 (Released:2006-07-05)

参考文献数

21

被引用文献数

1

---

Iron deficiency is the most common cause of anemia. Zinc, copper, manganese, molybdenum, and cobalt are also related to anemia. The body of an adult man stores approximately 4500 mg of iron. About 60% of this iron is in the form of hemoglobin, 20% is in the storage form of iron, 7% to 8% is contained in myoglobin in the muscle, and 12% to 13% is stored in iron-containing enzymes. The average amount of iron lost daily has been estimated to be approximately 1.0 mg in normal individuals. These losses are balanced by ingesting an equivalent amount of iron from the diet. Because of increasing iron needs of infants and adolescents during growth, and blood loss during menstruation in females, these patient groups may suffer from lack of iron, especially if they ingest inadequate amounts of iron from their meals. Pica is one of the symptomes of iron deficiency anemia. Pacophagia is one of clinical manifestation of pica which is characterized by eating ice. Measuring serum zinc before and after iron treatment in patients with iron deficiency anemia, we observed decrease of zinc concentration in patients with pica whereas normal zinc concentration in patients without pica. However there was no significance between two groups. Zinc deficiency leads to pathological signs related to impaired function of plasma membrane proteins such as erythrocyte plasma membrane. This impaired function causes hemolytic anemia. On the contrary, the excess of zinc also leads to anemia because suppression of iron absorption occur. Hypochromic microcytic anemia has been observed in copper deficiency. Since the activity of cytochrome oxidase, which contains copper, decrease in this condition, iron will not be mounted in heme followed by anemia because of failure of iron reduction. Ceruloplasmin, which also have copper, make iron to combine with transferrin by converting ferrous iron to ferric iron through oxidative process. Therefore, lack of ceruloplasmin cause anemia similar to that in iron deficiency.

著者

冨田 寛 田中 真琴 生井 明浩

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.18, no.1, pp.54-62, 2007 (Released:2007-05-29)

参考文献数

22

被引用文献数

7

---

1. In Japan, patients with taste disorder as a primary symptom of zinc deficiency are increasing.2. The incidence of taste disorder due to diet (insufficient intake of zinc) is especially high. The serum zinc value in patients with taste disorder due to diet was 20μg/dl (in many cases mean value is 60-79μg/dl )lower than the healthy group, but the half cases remained in more than 80μg/dl.3. The efficacy of oral administration of zinc in patients with taste disorder due to diet did not correlate with the zinc value before this therapy, but about 85%.4. Increasing rate of serum zinc values after the oral zinc therapy in patients with taste disorder due to diet was significantly high more than the placebo group. Lower serum zinc values in the patients were more effective. Correlate with the amount of oral administration of zinc.5. We would like to propose 80μg/dl as the diagnosis value(cutoff value) of zinc deficiency, referring to the above results and the conclusion of the Yokoi's study(Association between plasma zinc concentrations and zinc kinetic parameters in premenopausal women).

著者

倉澤 隆平 久堀 周治郎 奥泉 宏康 岡田 真平

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.22, no.1, pp.34-37, 2011 (Released:2013-09-09)

参考文献数

9

---

When conducting widespread medical examinations throughout our municipality, our team of clinicians discovered many subjects who exhibited symptoms of zinc deficiency despite having serum zinc levels above 65 µg/dL, the commonly accepted limit of zinc deficiency. In this paper, we propose that the range used to express zinc deficiency be adjusted upwards to a new limit of 80µg/dL. When our research team used this higher value in our diagnoses of community members involved in the study, we correctly diagnosed zinc deficiency 91% of the time, with only 9% of our diagnoses being false negatives. Using the new limit, 25% of patients may be falsely diagnosed with a zinc deficiency (false positive) if their complaints or physical signs are not appropriately considered.

著者

許斐 亜紀

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.26, no.3, pp.124-133, 2015-12-10 (Released:2015-12-17)

参考文献数

34

---

Iron (Fe) and zinc (Zn) are apt to be depleted in humans at the same time because of common food sources and common absorption inhibitors. In fact, there were several reports on the occurrence of simultaneous deficiency of Fe and Zn in some populations. Although many researchers investigated single deficiency of Fe or Zn, their interactions on biochemical and biological parameters are not clearly defined. We tried to determine the effect of dietary Fe and/or Zn deficiencies on rectal temperature, blood pressure, body water distribution, plasma erythropoietin level, blood biochemical parameters (lipids, protein and enzyme activity) and plasma mineral concentrations using experimental rats as a model for human zinc metabolism. Effects of combined deficiency of Fe and Zn were significantly different from those of single deficiency of Fe or Zn especially in body temperature. Body temperature was decreased by single deficiency of Fe or Zn, but combined deficiency of Fe and Zn did not change the temperature. Blood pressure is most decreased by combined deficiency of Fe and Zn, and plasma aldosterone concentration is also decreased by it. Fe and Zn deficiencies affect plasma Fe and Zn concentrations each other. Hence, future advancement of investigations on trace element interaction especially Fe and Zn is awaited.

著者

北條 慎太郎 深田 俊幸

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.23, no.1, pp.6-13, 2012 (Released:2012-10-01)

参考文献数

30

---

Zinc (Zn) confers structure and catalytic functions to a number of enzymes and transcription factors, and its homeostasis is tightly controlled by Zn transporters (SLC39/ZIP: importers, SLC30/ZnT: exporters). Zn is an essential trace element, and its deficiency is associated with abnormal endocrine-system reactions leading to vertebral growth retardation and metabolic disorders. However, the molecular mechanisms by which Zn affects the endocrine system remain to be clarified. Here we examined the in vivo roles of SLC39A14, a member of the SLC39 family, by generating its deficient mice. The Slc39a14-knockout (KO) mice exhibit growth retardation accompanied by abnormal chondrocyte differentiation, reduced growth hormone production, and an impaired gluconeogenic program. We found that these phenotypes are attributable to impaired G-protein coupled receptor (GPCR)-mediated signaling, via the parathyroid hormone 1 receptor (PTH1R), growth hormone releasing hormone receptor (GHRHR), and glucagon receptor (GCGR), respectively, due to the degradation of cyclic adenosine monophosphate (cAMP) by the higher phosphodiesterase (PDE) activity in the Slc39a14-KO mice. Thus, the Zn transporter SLC39A14 is a new regulator for GPCR-mediated signaling for systemic growth.

著者

武田 憲昭

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.21, no.1, pp.32-37, 2010 (Released:2013-09-09)

参考文献数

22

被引用文献数

1

---

We developed the ratio of apo/holo activities of angiotensin converting enzyme (ACE ratio) in the serum as an index of the zinc nutrition status. The zinc nutrition in patients with taste impairment was then estimated by dietary zinc intake, zinc concentration and ACE ratio in the serum. The results obtained in a series of our studies suggested that zinc deficiency is predominant factor underlying taste impairment even when zinc concentrations are within normal ranges in the serum and that ACE ratio is a more sensitive indicator of the zinc nutrition status than measuring zinc concentration in the serum. There were no differences of dietary intake of zinc after adjusting for energy and zinc concentration in the serum between patients and age-matched healthy subjects. But, ACE ratio in patients with taste impairment was significantly higher than that in age-matched healthy subjects. It is suggested that zinc deficiency in patients with taste impairment is due to malabsorption of dietary zinc from the duodenum and jejunum, but not low intake of dietary zinc.

著者

渡辺 和彦

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.20, no.4, pp.263-273, 2009 (Released:2013-09-09)

参考文献数

42

---

On comparison of the concentration of elements between plants and humans, there are not significant differences in calcium and iron. However, the concentration of boron in plants is 140 times higher than that in humans, and that of silicon is 35 times higher. High concentrations of boron and silicon are included in agricultural products but not in fish or meat. Therefore, humans depend on vegetables and cereal crops in order to ingest silicon and boron. Since silicon and boron are useful for improving human bone density, it could be considered that the source of a healthy body rests with soil improvement agents and fertilizers used to grow agricultural products. Recently, however, the manganese, zinc and copper contents of the agricultural products in Japan are have decreased. Our research in Hyogo Prefecture has found that compost for organic cultivation alone does not supply elements due to the mechanism of microorganism, thereby reducing the concentration of manganese in plants. It is supposed that copper combines with organic matter and zinc becomes insoluble with phosphorus. Compost contains a lot of these trace elements, but they are not as available as we had expected. Efficient application methods for the trace elements including foliar and seed treatments have already been established. It is important to provide advice that these trace elements need to be applied to growing plants along with compost.

著者

川原 正博 水野 大

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.26, no.1, pp.10-22, 2015-05-08 (Released:2015-05-28)

参考文献数

71

---

Increasing evidence suggests that dyshomeostasis of trace elements are implicated in the pathogenesis of various neurodegenerative diseases such as Alzheimer’s disease, prion diseases, and dementia with Lewy bodies. These diseases share similarity in the formation ofβ-sheet containing amyloid fibrils by disease-related proteins includingβ-amyloid protein (AβP), prion protein, α-synuclein, polyglutamine, and the introduction of apoptotic degeneration. Trace elements can bind to these proteins and cause their conformational changes. Furthermore, these proteins are co-localized in synapses and play crucial roles in the regulation of trace elements. Thus, it is possible that the interactions between the disease-related proteins and trace elements are based on the physiological roles of these proteins. We review here the current understanding of the pathology of the neurodegenerative diseases based on the metal-binding to disease-related proteins and on the disruption of metal homeostasis.

著者

小谷 明

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.22, no.1, pp.22-26, 2011 (Released:2013-09-09)

参考文献数

13

---

Cisplatin, clinically used anticancer Pt(II) complex, has been believed to attack DNA to form Pt-N7(Guanine) coordination, and Pt-G bond is protected from DNA repair enzyme by the aromatic ring stacking between Pt-G and Phe side chain in Pt-DNA-HMG protein adduct. The adduct mimicked 4N coordinated Pt(II) complexes M(DA)(AtCn) involving with metal coordinated aromatic diamine (DA) and anthracene ring side chain in AtCn, which could not coordinate DNA, showed not only in vitro cytotoxicity for human cancer cell lines but also strong inhibition with protein interaction such as the proteasome. The bio-activity indicated the structural dependence of both DA and AtCn. This should relate with the intramolecular aromatic ring stacking interaction which was evidenced by the X-ray structure in crystal and the H-1 NMR in H2O solution. Importantly the Pt(II) complexes showed similar bioactivity in cisplatin resistance cancer cell. These experimental results showed that the Pt complexes involving stacking structure might be new type anticancer metal compounds.

著者

山下 倫明 今村 伸太朗 藪 健史 石原 賢司 山下 由美子

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.24, no.4, pp.176-184, 2013 (Released:2014-01-22)

参考文献数

51

---

Selenium is an essential micronutrient for humans, and seafood is one of the major selenium source in Japan. Recent studies show that the tissues of tuna and other predatory fish contain high levels of the selenium-containing imidazole compound, 2-selenyl-Nα, Nα, Nα-trimethyl-L-histidine (selenoneine). A substantial proportion of the total amount of selenium is present as selenoneine in the muscles of ocean fish. Selenoneine contains an imidazole ring with a unique selenoketone group and has an antioxidant activity in vitro and in vivo. The dietary intake of selenoneine through fish consumption is thought to be important for enhancing selenium redox functions in tissues and cells. In addition, selenoneine accelerated the excretion and demethylation of methylmercury through the formation of secretory extracellular lysosomal vesicles via the specific organic cation/carnitine transporter-1 (OCTN1). Dietary intake of selenoneine might decrease the formation of hydroxyl and other radicals and accelerate the excretion of heavy metals, and thereby inhibit carcinogenesis, lifestyle chronic diseases, and aging.

著者

倉澤 隆平 久堀 周治郎 奥泉 宏康

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.21, no.1, pp.1-12, 2010 (Released:2013-09-09)

参考文献数

13

被引用文献数

1

---

It is well known that zinc is an essential trace element for maintaining human health. However, there is a paucity of literature describing cases of zinc deficiency, leading many physicians to believe that zinc deficiency is a rare occurrence. Nevertheless, we have found many zinc-deficient patients at our Kitamimaki-onsen clinic since 2002, and reported their symptoms at the annual meeting of this BRTE society held in 2005. Their complaints were anorexia, general fatigue, impaired sense of taste, burning mouth, various types of skin lesion, delayed wound healing, emotional instability, and others. Each of these wide ranging complaints can be induced by zinc depletion, though they do not necessarily manifest themselves simultaneously. The reasons why such a wide range of symptoms appear in cases of zinc deficiency are becoming more apparent, due to recent studies advancing our knowledge on the functions of zinc-related proteins such as zinc transporters and zincrelated metaloenzymes. In this paper, we offer possible explanations on the relationship between zinc depletion and the onset of the abovenoted symptoms, and discuss the limitations of using serum zinc levels to detect and diagnose zinc deficiency.

著者

篠原 厚子 千葉 百子 中埜 拓 稲葉 裕

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.15, no.1, pp.49-53, 2004 (Released:2005-04-08)

参考文献数

5

---

The concentrations of 48 kinds of major and trace elements in dry milk were determined by microwave-induced plasma mass spectrometry, atomic absorption spectrometry, or colorimetry. The order of the element concentrations in dry milk was K > Ca, P > Na > Mg >> Zn > Rb > Fe > Sr > Cu, Ba, Ni, Mo, Mn, As > Se, Co, Cr. Other elements determined were much lower or under detection limit. Element concentrations in fractions of milk (skim milk, butter milk, acidic casein, whey, whey protein concentrate (WPC), and milk mineral) were also determined. The concentrations of each element in these powdered samples were dependent on the fractions. Concentrations of Ca and Mg in skim milk, butter milk, whey and WPC were similar to those in dry milk, but those in acidic casein fraction were very low and those in milk mineral fraction were extremely high. The concentrations of P in milk mineral fraction were about twice of dry milk, and Na was almost the same, and K was lower than those in dry milk. The present study indicates that the milk mineral fraction is a good source of Ca and Mg.

著者

松田 晃彦 武田 隆久 木村 美恵子

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.19, no.4, pp.297-307, 2008-12-31 (Released:2009-07-01)

参考文献数

32

被引用文献数

1

---

Selenium (Se) is an essential trace element and component of glutathione peroxidase known to be involved in the reduction of free radicals. Reduction of body Se is easily induced by the external Se-deficient environment, but the symptoms of Se deficiency such as cardiomyopathy, weakness of muscle strength, muscle pain, anemia, and white nail are rarely seen in human. In this review paper, we describe that the appearance of functional disorders following Se deficiency in rats is not easily appeared, and that Se deficiency in rats reduces toxic threshold of anticancer drug “adriamycin”. And also, we consider the significance of prevention of Se deficiency based on the results of these animal studies.

著者

柳澤 裕之 山内 博

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.20, no.1, pp.1-2, 2009-04-01 (Released:2009-07-01)

著者

圓谷 奈保美 本間 謙吾 西頭 英起 一條 秀憲

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.23, no.1, pp.14-23, 2012 (Released:2013-09-09)

参考文献数

79

---

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the selective loss of upper and lower motoneurons. Approximately 10% of all ALS cases are genetically inherited, and a mutation in the Cu, Zn superoxide dismutase (SOD1) gene is thought to be a cause of motoneuron dysfunction. Importantly, the motoneuron toxicity appears to result from a toxic gain-of-function mutation in SOD1 and not from the loss of superoxide dismutase activity. Transgenic mice overexpressing several types of SOD1 mutant show the ALS-like phenotype and are widely accepted as animal models of ALS. However, no common toxic mechanism has been identified among these SOD1 mutants. Studies using autopsies of ALS patients or model mouse have suggested multiple causes of ALS including oxidative stress, mitochondrial dysfunction, excitotoxicity, neurofilaments abnormality and protein aggregation. Endoplasmic reticulum (ER) stress mediated motoneuron death is also suggested to be included in the pathogenesis of ALS. ALS-related mutant SOD1 evokes ER stress through the specific interaction with Derlin-1, a component of ER associated degradation (ERAD) machinery, leading to the subsequent motoneuron death. Zinc plays an important role in the function of nervous system and its dyshomeostasis is also thought to be one of the causes of ALS. In fact, zinc accumulation is observed in the brains and the spinal cords of mutant SOD1 transgenic mice. Moreover, zinc chelation extends the life span of these mise. There seems to be relationships between zinc dysregulation and several pathogenic processes of ALS. In this review, we will focus on the pathological role of ER stress and zinc in ALS.

著者

渋市 郁雄 安江 正明 加藤 克彦 渡邉 泰雄

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.17, no.1, pp.11-16, 2006 (Released:2006-09-13)

参考文献数

24

被引用文献数

1

---

This paper argues the possible effects of natural vanadium-containing Mt. Fuji ground water on the hyperglycemia based on our previously reported animal and clinical studies. In the animal studies, we documented that the activities of liver insulin receptors, particularly β subunit, and primary insulin-like growth factor-1 β were recovered to the normal levels by the daily forced oral treatment with Mt. Fuji ground water containing natural vanadium in Goto-Kakisaki (GK) rat which is the genetic model of Type II diabetes. Furthermore the increased levels of blood glucose and serum hemoglobin A1C (HbA1C) of GK rats were significantly blocked by the consecutive treatment of natural vanadium water. It is interesting that the other genetic model of Type II diabetes, KKAy mice, were likely to be shown the inhibitory effects of the consecutive treatment of natural vanadium water on increases of blood glucose but not significant. In these animals, however, the significant improvements of Glut 4 transporter and receptor activities in the adipose and muscle were detected. In the clinical studies, the levels of blood glucose and serum HbA1C of hyperglycemic patients were significantly reduced by three month consecutive treatment of this Mt. Fuji ground water, and also the QOL of these patients were completely improved, although these effects were clearly affected by the changes in each life style. Thus both animal and human studies suggest that the daily treatment with Mt. Fuji ground water containing natural vanadium is useful for the regulation of blood glucose levels and the improvement of QOL to the hyperglycemia patients due to the improvements of glucose transporter and the insulin receptor and so on. However it might be little difficult to expect the significant improvement of the severe conditions of diabetes mellitus by the consecutive treatment of natural vanadium water, since this ground water is good as a supplement.

著者

川原 正博

出版者

日本微量元素学会

雑誌

Biomedical research on trace elements (ISSN:0916717X)

巻号頁・発行日

vol.12, no.3, pp.207-216, 2001-09-30

参考文献数

65

被引用文献数

6

著者

水野 佑紀 藤森 英治 吉永 淳

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.28, no.4, pp.154-161, 2018-02-28 (Released:2018-04-10)

参考文献数

9

---

Urinary cadmium (Cd) concentration has been used as a biomarker of long-term exposure to this metal in the previous researches. ICP mass spectrometry (ICP-MS) has become a method of choice for measuring urinary Cd concentrations, however, spectral interference from molybdenum oxide (MoO) has to be removed/corrected for accurate analysis. This study evaluated (1) MoO spectral interference in urinary Cd determination by ICP-MS, and (2) the performance of chelate-resin solid phase extraction (SPE) for removal of the interference. Cadmium concentrations in human urine certified reference materials and human urine samples from a male subject were determined by ICP-MS with mathematical MoO interference correction and ICP-MS preceded by SPE, as well as those by electrothermal atomic absorption spectrometry (ETAAS). The sensitivity and accuracy of the determination of urinary Cd was generally satisfactory for all the 3 methods; however, ICP-MS without SPE was found to give a deviated Cd concentrations for urine samples with higher Mo/Cd ratio due to uncertainty in interference correction. It was concluded that ICP-MS with mathematical interference correction is suitable as a routine method for measuring urinary Cd concentrations, but ICP-MS with SPE can be a method of choice for urine with high Mo/Cd ratio and for highly sensitive and accurate urinary Cd analysis.

著者

深田 俊幸

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.26, no.1, pp.1-6, 2015-05-08 (Released:2015-05-28)

参考文献数

26

---

Zinc is an essential trance element, and its homeostasis is controlled by zinc transporter family members. Various approaches have revealed the important roles of zinc homeostasis by zinc transporters in cellular functions, and manifested a role for zinc as a signaling factor: zinc signaling. This short review introduces the zinc biology and zinc signaling with their basic and historical backgrounds.

著者

野本 昭三 山内 一由 中林 徹雄

出版者

日本微量元素学会

雑誌

Biomedical research on trace elements (ISSN:0916717X)

巻号頁・発行日

vol.14, no.4, pp.335-337, 2003-12-30

参考文献数

4

被引用文献数

5