著者
安田 寛
出版者
Japan Society for Biomedical Research on Trace Elements
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.27, no.3, pp.125-140, 2017-01-25 (Released:2017-03-16)
参考文献数
89

The importance of zinc for human health has been recognized since the early 1960s, but today there is little concern about zinc deficiency in developed countries. We measured the zinc concentration in hair from 28,424 Japanese subjects (18,812 females and 9,612 males) and found that 1,754 individuals (6.17 %) had zinc concentrations lower than the -2 standard deviations level (86.3 ppm) of its control reference range, which qualifies as zinc deficiency. A considerable proportion of elderlies and children (20 % or more) were found to have marginal to severe zinc deficiency. A minimum zinc concentration of 9.7 ppm was observed in a 51-year-old woman; this concentration was approximately 1/13 of the mean reference level. The prevalence of zinc deficiency in adults increased with aging from 1-2 % in the young to a peak of 19.7 % in the 8th decade of life, and decreased to 3.4 % or less in the longevities above 90-year-old. The prevalence of zinc deficiency in children aged 0–9 years was 29.9 % in males and 33.8 % in females.In the study for 1,967 children with autistic disorders (1,553 males and 414 females), 584 individuals (29.7 %) were found deficient in zinc, and its deficiency rate in infantile group aged 0–3 years was 43.5 % in male and 52.5 % in female. Next to zinc, 347 (17.6 %) and 114 (5.8 %) individuals were deficient in magnesium and calcium, and 2.0% or less in the other essential metals such as iron, cupper or manganese. In contrast, 339 (17.2 %), 168 (8.5 %) and 94 (4.8 %) individuals were found suffering from high burden of aluminum, cadmium and lead, and 2.8 % or less from mercury and arsenic burden. These findings suggest that infantile zinc deficiency and toxic metal burdens may epigenetically play pivotal roles as environmental factors in the pathogenesis of autism spectrum disorders (ASDs) and that metallomics approach helps lead to early screening and intervention/treatment of the neurodevelopment disorders.This review demonstrates that infant and elderly are liable to zinc deficiency and that many infants with autistic disorders are suffering from zinc deficiency and toxic metal burdens, suggesting the presence of “infantile time window” in neurodevelopment and probably for therapy. These findings suggest that early assessment and intervention of zinc deficiency is possibly effective for infants with autistic disorders and essential for normal development, health and longevity.
著者
布施 養善
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.24, no.3, pp.117-152, 2013 (Released:2013-10-29)
参考文献数
222

Iodine is a chemical element with atomic number 53 and one of the most valuable natural resources among the halogen elements. One third of all iodine in the world is produced in Japan. Japan has been regarded as an iodine-sufficient or even excessive country because Japanese has been consuming traditionally large amounts of iodine largely through the intake of seaweed. However, there is no national data on iodine nutrition and its relation to diseases. In this review, a variety of aspects of iodine and also iodine status in Japan is discussed.
著者
中村 道子
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.16, no.1, pp.12-18, 2005 (Released:2006-07-05)
参考文献数
31
被引用文献数
2

The trace elements play important roles in the human brain. The knowledge on the trace elements and neuropsychiatric disorders were comprehensively reviewed. These include iron, zinc, copper, iodine, lithium, aluminum, manganese, lead and mercury. Some metals have toxic actions on nerve cells and neurobehavioral functioning. The toxic actions could be expressed either as developmental effects or as an increased risk of neurodegenerative diseases in old age. Redox metals, which were iron, copper, and zinc in the brain, play many important roles in maintenance of cellular function.
著者
Manfred Anke Mario Müller Christine Hoppe
出版者
Japan Society for Biomedical Research on Trace Elements
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.16, no.3, pp.183-187, 2005 (Released:2006-04-20)
参考文献数
22

Nine generations of goats receiving 2.5 to 6.5 mg Al/kg feed dry matter (DM) developed significantly increased mortality, impaired success of first insemination, an increased rate of abortions and, in the fourth generation, a distinct weakness of the hindlegs. Aluminum-poor nutrition led to significant variations of Al contents of aorta, spleen and bones. This effect of aluminum-poor nutrition was also evident in chickens. The normative requirement of animals is < 10 mg Al/kg diet DM. A potential daily normative aluminum requirement - if it should exist - is < 2000 μg, on the average of a week. The aluminum requirement of animals and man is satisfied by the natural aluminum offer.
著者
圓谷 奈保美 本間 謙吾 西頭 英起 一條 秀憲
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.23, no.1, pp.14-23, 2012 (Released:2013-09-09)
参考文献数
79

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the selective loss of upper and lower motoneurons. Approximately 10% of all ALS cases are genetically inherited, and a mutation in the Cu, Zn superoxide dismutase (SOD1) gene is thought to be a cause of motoneuron dysfunction. Importantly, the motoneuron toxicity appears to result from a toxic gain-of-function mutation in SOD1 and not from the loss of superoxide dismutase activity. Transgenic mice overexpressing several types of SOD1 mutant show the ALS-like phenotype and are widely accepted as animal models of ALS. However, no common toxic mechanism has been identified among these SOD1 mutants. Studies using autopsies of ALS patients or model mouse have suggested multiple causes of ALS including oxidative stress, mitochondrial dysfunction, excitotoxicity, neurofilaments abnormality and protein aggregation. Endoplasmic reticulum (ER) stress mediated motoneuron death is also suggested to be included in the pathogenesis of ALS. ALS-related mutant SOD1 evokes ER stress through the specific interaction with Derlin-1, a component of ER associated degradation (ERAD) machinery, leading to the subsequent motoneuron death. Zinc plays an important role in the function of nervous system and its dyshomeostasis is also thought to be one of the causes of ALS. In fact, zinc accumulation is observed in the brains and the spinal cords of mutant SOD1 transgenic mice. Moreover, zinc chelation extends the life span of these mise. There seems to be relationships between zinc dysregulation and several pathogenic processes of ALS. In this review, we will focus on the pathological role of ER stress and zinc in ALS.
著者
水野 佑紀 藤森 英治 吉永 淳
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.28, no.4, pp.154-161, 2018-02-28 (Released:2018-04-10)
参考文献数
9

Urinary cadmium (Cd) concentration has been used as a biomarker of long-term exposure to this metal in the previous researches. ICP mass spectrometry (ICP-MS) has become a method of choice for measuring urinary Cd concentrations, however, spectral interference from molybdenum oxide (MoO) has to be removed/corrected for accurate analysis. This study evaluated (1) MoO spectral interference in urinary Cd determination by ICP-MS, and (2) the performance of chelate-resin solid phase extraction (SPE) for removal of the interference. Cadmium concentrations in human urine certified reference materials and human urine samples from a male subject were determined by ICP-MS with mathematical MoO interference correction and ICP-MS preceded by SPE, as well as those by electrothermal atomic absorption spectrometry (ETAAS). The sensitivity and accuracy of the determination of urinary Cd was generally satisfactory for all the 3 methods; however, ICP-MS without SPE was found to give a deviated Cd concentrations for urine samples with higher Mo/Cd ratio due to uncertainty in interference correction. It was concluded that ICP-MS with mathematical interference correction is suitable as a routine method for measuring urinary Cd concentrations, but ICP-MS with SPE can be a method of choice for urine with high Mo/Cd ratio and for highly sensitive and accurate urinary Cd analysis.
著者
深田 俊幸
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.26, no.1, pp.1-6, 2015-05-08 (Released:2015-05-28)
参考文献数
26

Zinc is an essential trance element, and its homeostasis is controlled by zinc transporter family members. Various approaches have revealed the important roles of zinc homeostasis by zinc transporters in cellular functions, and manifested a role for zinc as a signaling factor: zinc signaling. This short review introduces the zinc biology and zinc signaling with their basic and historical backgrounds.
著者
冨田 寛 田中 真琴 生井 明浩
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.18, no.1, pp.54-62, 2007 (Released:2007-05-29)
参考文献数
22
被引用文献数
7

1. In Japan, patients with taste disorder as a primary symptom of zinc deficiency are increasing.2. The incidence of taste disorder due to diet (insufficient intake of zinc) is especially high. The serum zinc value in patients with taste disorder due to diet was 20μg/dl (in many cases mean value is 60-79μg/dl )lower than the healthy group, but the half cases remained in more than 80μg/dl.3. The efficacy of oral administration of zinc in patients with taste disorder due to diet did not correlate with the zinc value before this therapy, but about 85%.4. Increasing rate of serum zinc values after the oral zinc therapy in patients with taste disorder due to diet was significantly high more than the placebo group. Lower serum zinc values in the patients were more effective. Correlate with the amount of oral administration of zinc.5. We would like to propose 80μg/dl as the diagnosis value(cutoff value) of zinc deficiency, referring to the above results and the conclusion of the Yokoi's study(Association between plasma zinc concentrations and zinc kinetic parameters in premenopausal women).
著者
玉利 祐三
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.16, no.3, pp.250-257, 2005 (Released:2006-04-20)
参考文献数
26
被引用文献数
1

Lithium carbonate is known as medical supplies for the remedy or prevention of manic-depressive psychosis. Blood lithium concentrations of their patients generally should be monitored during their hospital-treatments not to beyond the toxic concentration level of lithium. When heparin is usually added to a blood sample for preventing the blood-coagulation, impurity lithium of the reagent gives a positive error for the determination of lithium concentration of the blood. In this work the lithium concentration was determined by flame photometry after the decomposition of a sample with nitric-perchloric acids or hydrofluoric-nitric-perchloric acids for food samples. In the chemicals used for anticoagulant it was found that sodium citrate, heparin sodium salt and EDTA-2Na contained high amounts of lithium as impurity; 422, 221and 204 ng/g, respectively, whereas lithium was not detected in EDTA-4H and citric acid. Impurity lithium content of chemicals of general salt of sodium, potassium, magnesium and calcium were also tested; there was a fact that considerable amounts of lithium, 39500 and 14000 ng/g, existed in high purity of calcium metal and its carbonate. The Li/Ca ratio of the content of calcium salt (chemicals, n=36) was almost constant, and there was a good correlation between lithium and calcium content. The same tendency of the constant ratio of Li/Ca for the chemicals was also found in natural carbonate minerals of calcite, dolomite and aragonite, and biological materials of human milk, human serum, mammalian bone and oyster shell. On the other hand, lithium concentrations of plasma of healthy Japanese and Korean female were investigated, and the relationship between plasma lithium concentration and daily dietary lithium intake of the healthy people at urban district and village near seashore were also investigated in Korea. There was no significant difference between dietary lithium intake and plasma lithium concentration for the healthy people. Plasma lithium concentration was almost constant to be 11±2 ng/g (n=164) for healthy people.
著者
山下 倫明 今村 伸太朗 藪 健史 石原 賢司 山下 由美子
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.24, no.4, pp.176-184, 2013 (Released:2014-01-22)
参考文献数
51

Selenium is an essential micronutrient for humans, and seafood is one of the major selenium source in Japan. Recent studies show that the tissues of tuna and other predatory fish contain high levels of the selenium-containing imidazole compound, 2-selenyl-Nα, Nα, Nα-trimethyl-L-histidine (selenoneine). A substantial proportion of the total amount of selenium is present as selenoneine in the muscles of ocean fish. Selenoneine contains an imidazole ring with a unique selenoketone group and has an antioxidant activity in vitro and in vivo. The dietary intake of selenoneine through fish consumption is thought to be important for enhancing selenium redox functions in tissues and cells. In addition, selenoneine accelerated the excretion and demethylation of methylmercury through the formation of secretory extracellular lysosomal vesicles via the specific organic cation/carnitine transporter-1 (OCTN1). Dietary intake of selenoneine might decrease the formation of hydroxyl and other radicals and accelerate the excretion of heavy metals, and thereby inhibit carcinogenesis, lifestyle chronic diseases, and aging.
著者
渡辺 和彦
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.20, no.4, pp.263-273, 2009 (Released:2013-09-09)
参考文献数
42

On comparison of the concentration of elements between plants and humans, there are not significant differences in calcium and iron. However, the concentration of boron in plants is 140 times higher than that in humans, and that of silicon is 35 times higher. High concentrations of boron and silicon are included in agricultural products but not in fish or meat. Therefore, humans depend on vegetables and cereal crops in order to ingest silicon and boron. Since silicon and boron are useful for improving human bone density, it could be considered that the source of a healthy body rests with soil improvement agents and fertilizers used to grow agricultural products. Recently, however, the manganese, zinc and copper contents of the agricultural products in Japan are have decreased. Our research in Hyogo Prefecture has found that compost for organic cultivation alone does not supply elements due to the mechanism of microorganism, thereby reducing the concentration of manganese in plants. It is supposed that copper combines with organic matter and zinc becomes insoluble with phosphorus. Compost contains a lot of these trace elements, but they are not as available as we had expected. Efficient application methods for the trace elements including foliar and seed treatments have already been established. It is important to provide advice that these trace elements need to be applied to growing plants along with compost.
著者
川原 正博 水野 大
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.26, no.1, pp.10-22, 2015-05-08 (Released:2015-05-28)
参考文献数
71

Increasing evidence suggests that dyshomeostasis of trace elements are implicated in the pathogenesis of various neurodegenerative diseases such as Alzheimer’s disease, prion diseases, and dementia with Lewy bodies. These diseases share similarity in the formation ofβ-sheet containing amyloid fibrils by disease-related proteins includingβ-amyloid protein (AβP), prion protein, α-synuclein, polyglutamine, and the introduction of apoptotic degeneration. Trace elements can bind to these proteins and cause their conformational changes. Furthermore, these proteins are co-localized in synapses and play crucial roles in the regulation of trace elements. Thus, it is possible that the interactions between the disease-related proteins and trace elements are based on the physiological roles of these proteins. We review here the current understanding of the pathology of the neurodegenerative diseases based on the metal-binding to disease-related proteins and on the disruption of metal homeostasis.
著者
植村 雅子 米田 誠治
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.26, no.4, pp.157-165, 2016-03-22 (Released:2016-04-14)
参考文献数
43

Platinum-based anticancer drugs, represented by cisplatin, play important roles in present cancer chemotherapy. Although three or five platinum-based drugs have been approved for clinical use worldwide or in Japan, many active researches are still ongoing to seek next generation platinum-based drugs with less side effect and higher efficacy. Tetrazolato-bridged dinuclear platinum(II) complexes (tetrazolato-bridged complex) are distinctively different from existing platinum-based drugs in cytotoxicity spectra, DNA interactions, and cellular uptake profiles, probably due to their unique structures. Tetrazolato-bridged complexes provide high in vivo antitumor activity toward pancreatic cancer which is difficult to cure. In this review, we introduce the recent drug development researches on platinum-based drugs and update the latest findings of tetrazolato-bridged complex.
著者
小椋 康光
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.20, no.3, pp.240-246, 2009-10-01 (Released:2009-12-16)
参考文献数
18

Although selenium (Se) and tellurium (Te) are non-essential elements in plants, they are utilized in metabolic pathways to form the metalloid-containing compounds having carbon-metalloid covalent bond(s) (organic seleno/tellurometabolites). Therefore, it is necessary to identify seleno/tellurocompounds to determine the metabolic pathway of Se and Te, and understand the beneficial or toxicological effects of these compounds. Many literatures showed that the complementary use of HPLC-ICP-MS and HPLC-ESI (APCI)-MS/MS is a powerful tool for the speciation and identification of these metabolites. In this review, our recent works on the complementary use of ICP-MS, ESI-MS/MS and NMR from the viewpoint of identification of unknown seleno/tellurometabolites in plant samples were summarized. In particular, (1) speciation of sulfur (S) and Se-containing amino acids in Allium plants, (2) identification of a novel selenocompound in selenized Japanese pungent radish, (3) evaluation of function and translation efficacy of selenomethionine (SeMet)-containing proteins, (4) identification of SeMet-metabolites in wheat germ extracts, and (5) evaluation of Te metabolism in the Se-accumulating plant were mentioned.
著者
倉澤 隆平 久堀 周治郎 奥泉 宏康
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.21, no.1, pp.1-12, 2010 (Released:2013-09-09)
参考文献数
13
被引用文献数
1

It is well known that zinc is an essential trace element for maintaining human health. However, there is a paucity of literature describing cases of zinc deficiency, leading many physicians to believe that zinc deficiency is a rare occurrence. Nevertheless, we have found many zinc-deficient patients at our Kitamimaki-onsen clinic since 2002, and reported their symptoms at the annual meeting of this BRTE society held in 2005. Their complaints were anorexia, general fatigue, impaired sense of taste, burning mouth, various types of skin lesion, delayed wound healing, emotional instability, and others. Each of these wide ranging complaints can be induced by zinc depletion, though they do not necessarily manifest themselves simultaneously. The reasons why such a wide range of symptoms appear in cases of zinc deficiency are becoming more apparent, due to recent studies advancing our knowledge on the functions of zinc-related proteins such as zinc transporters and zincrelated metaloenzymes. In this paper, we offer possible explanations on the relationship between zinc depletion and the onset of the abovenoted symptoms, and discuss the limitations of using serum zinc levels to detect and diagnose zinc deficiency.
著者
Manfred Anke Wolfram Dorn Mario Müller Mathias Seifert
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.16, no.3, pp.198-202, 2005 (Released:2006-04-20)
参考文献数
19

Cadmium-poor nutrition (< 15 μg Cd/kg feed dry matter (DM)) did not affect feed intake and growth rate, while it affected reproduction performance. Intrauterinally cadmium-depleted kids were often phlegmatic, too lazy to eat and drink, and died of muscle weakness. With oral application of the control feed (300 μg Cd/kg DM), they slowly regained their mobility. Feeding them 65 μg Cd/kg feed DM prevented myasthenia. The normative cadmium requirement of goats (and animals in general) amounts to < 20 μg/kg diet DM. The daily requirement of humans might be < 3 μg.
著者
Hiroshi Yasuda Toshie Yonashiro Kazuya Yoshida Tomiko Ishii Toyoharu Tsutsui
出版者
日本微量元素学会
雑誌
Biomedical Research on Trace Elements (ISSN:0916717X)
巻号頁・発行日
vol.16, no.4, pp.285-292, 2005 (Released:2006-07-19)
参考文献数
35
被引用文献数
4

In order to investigate any role of minerals in autistic disorders, we measured 24 mineral contents in scalp hair samples of 360 autistic children and compared with those of healthy controls. In the male autistic group aged 4-9 years (N=200), the geometric means of many element levels, namely not only essential minerals such as cobalt, chromium, iodine, molybdenum and phosphorus, but also nickel, boron, cadmium and lead were significantly lower than those in the control group (p<0.001). In contrast, selenium level was significantly higher in the autistic group. On the mercury levels, no significant difference was observed between the two groups, though with a tendency of low concentration in the autistic group. Similar mineral imbalance profiles with a global mineral deficiency were observed in the other autistic groups aged 0-3 and 10-15 years (N=85 and 20) and also in the female autistic groups. In addition, high accumulation of a few elements such as iron, manganese, chromium, copper, sodium, aluminum, cadmium, lead, or mercury was observed in some autistic individuals. These findings indicate that autistic children are suffered from a global mineral deficiency in various trace elements, with some individuals being exposed to a marked accumulation of several elements. Autistic children may be classified to sub-groups, based on their mineral imbalance profile in hair.
著者
大村 実
出版者
日本微量元素学会
雑誌
Biomedical research on trace elements (ISSN:0916717X)
巻号頁・発行日
vol.13, no.3, pp.149-157, 2002-09-30