著者

安田 寛

出版者

Japan Society for Biomedical Research on Trace Elements

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.27, no.3, pp.125-140, 2017-01-25 (Released:2017-03-16)

参考文献数

89

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The importance of zinc for human health has been recognized since the early 1960s, but today there is little concern about zinc deficiency in developed countries. We measured the zinc concentration in hair from 28,424 Japanese subjects (18,812 females and 9,612 males) and found that 1,754 individuals (6.17 %) had zinc concentrations lower than the -2 standard deviations level (86.3 ppm) of its control reference range, which qualifies as zinc deficiency. A considerable proportion of elderlies and children (20 % or more) were found to have marginal to severe zinc deficiency. A minimum zinc concentration of 9.7 ppm was observed in a 51-year-old woman; this concentration was approximately 1/13 of the mean reference level. The prevalence of zinc deficiency in adults increased with aging from 1-2 % in the young to a peak of 19.7 % in the 8th decade of life, and decreased to 3.4 % or less in the longevities above 90-year-old. The prevalence of zinc deficiency in children aged 0–9 years was 29.9 % in males and 33.8 % in females.In the study for 1,967 children with autistic disorders (1,553 males and 414 females), 584 individuals (29.7 %) were found deficient in zinc, and its deficiency rate in infantile group aged 0–3 years was 43.5 % in male and 52.5 % in female. Next to zinc, 347 (17.6 %) and 114 (5.8 %) individuals were deficient in magnesium and calcium, and 2.0% or less in the other essential metals such as iron, cupper or manganese. In contrast, 339 (17.2 %), 168 (8.5 %) and 94 (4.8 %) individuals were found suffering from high burden of aluminum, cadmium and lead, and 2.8 % or less from mercury and arsenic burden. These findings suggest that infantile zinc deficiency and toxic metal burdens may epigenetically play pivotal roles as environmental factors in the pathogenesis of autism spectrum disorders (ASDs) and that metallomics approach helps lead to early screening and intervention/treatment of the neurodevelopment disorders.This review demonstrates that infant and elderly are liable to zinc deficiency and that many infants with autistic disorders are suffering from zinc deficiency and toxic metal burdens, suggesting the presence of “infantile time window” in neurodevelopment and probably for therapy. These findings suggest that early assessment and intervention of zinc deficiency is possibly effective for infants with autistic disorders and essential for normal development, health and longevity.

著者

前田 美穂

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.1, pp.19-24, 2005 (Released:2006-07-05)

参考文献数

21

被引用文献数

1

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Iron deficiency is the most common cause of anemia. Zinc, copper, manganese, molybdenum, and cobalt are also related to anemia. The body of an adult man stores approximately 4500 mg of iron. About 60% of this iron is in the form of hemoglobin, 20% is in the storage form of iron, 7% to 8% is contained in myoglobin in the muscle, and 12% to 13% is stored in iron-containing enzymes. The average amount of iron lost daily has been estimated to be approximately 1.0 mg in normal individuals. These losses are balanced by ingesting an equivalent amount of iron from the diet. Because of increasing iron needs of infants and adolescents during growth, and blood loss during menstruation in females, these patient groups may suffer from lack of iron, especially if they ingest inadequate amounts of iron from their meals. Pica is one of the symptomes of iron deficiency anemia. Pacophagia is one of clinical manifestation of pica which is characterized by eating ice. Measuring serum zinc before and after iron treatment in patients with iron deficiency anemia, we observed decrease of zinc concentration in patients with pica whereas normal zinc concentration in patients without pica. However there was no significance between two groups. Zinc deficiency leads to pathological signs related to impaired function of plasma membrane proteins such as erythrocyte plasma membrane. This impaired function causes hemolytic anemia. On the contrary, the excess of zinc also leads to anemia because suppression of iron absorption occur. Hypochromic microcytic anemia has been observed in copper deficiency. Since the activity of cytochrome oxidase, which contains copper, decrease in this condition, iron will not be mounted in heme followed by anemia because of failure of iron reduction. Ceruloplasmin, which also have copper, make iron to combine with transferrin by converting ferrous iron to ferric iron through oxidative process. Therefore, lack of ceruloplasmin cause anemia similar to that in iron deficiency.

著者

布施 養善

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.24, no.3, pp.117-152, 2013 (Released:2013-10-29)

参考文献数

222

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Iodine is a chemical element with atomic number 53 and one of the most valuable natural resources among the halogen elements. One third of all iodine in the world is produced in Japan. Japan has been regarded as an iodine-sufficient or even excessive country because Japanese has been consuming traditionally large amounts of iodine largely through the intake of seaweed. However, there is no national data on iodine nutrition and its relation to diseases. In this review, a variety of aspects of iodine and also iodine status in Japan is discussed.

著者

冨田 寛 田中 真琴 生井 明浩

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.18, no.1, pp.54-62, 2007 (Released:2007-05-29)

参考文献数

22

被引用文献数

7

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1. In Japan, patients with taste disorder as a primary symptom of zinc deficiency are increasing.2. The incidence of taste disorder due to diet (insufficient intake of zinc) is especially high. The serum zinc value in patients with taste disorder due to diet was 20μg/dl (in many cases mean value is 60-79μg/dl )lower than the healthy group, but the half cases remained in more than 80μg/dl.3. The efficacy of oral administration of zinc in patients with taste disorder due to diet did not correlate with the zinc value before this therapy, but about 85%.4. Increasing rate of serum zinc values after the oral zinc therapy in patients with taste disorder due to diet was significantly high more than the placebo group. Lower serum zinc values in the patients were more effective. Correlate with the amount of oral administration of zinc.5. We would like to propose 80μg/dl as the diagnosis value(cutoff value) of zinc deficiency, referring to the above results and the conclusion of the Yokoi's study(Association between plasma zinc concentrations and zinc kinetic parameters in premenopausal women).

著者

倉澤 隆平 久堀 周治郎 奥泉 宏康 岡田 真平

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.22, no.1, pp.34-37, 2011 (Released:2013-09-09)

参考文献数

9

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When conducting widespread medical examinations throughout our municipality, our team of clinicians discovered many subjects who exhibited symptoms of zinc deficiency despite having serum zinc levels above 65 µg/dL, the commonly accepted limit of zinc deficiency. In this paper, we propose that the range used to express zinc deficiency be adjusted upwards to a new limit of 80µg/dL. When our research team used this higher value in our diagnoses of community members involved in the study, we correctly diagnosed zinc deficiency 91% of the time, with only 9% of our diagnoses being false negatives. Using the new limit, 25% of patients may be falsely diagnosed with a zinc deficiency (false positive) if their complaints or physical signs are not appropriately considered.

著者

許斐 亜紀

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.26, no.3, pp.124-133, 2015-12-10 (Released:2015-12-17)

参考文献数

34

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Iron (Fe) and zinc (Zn) are apt to be depleted in humans at the same time because of common food sources and common absorption inhibitors. In fact, there were several reports on the occurrence of simultaneous deficiency of Fe and Zn in some populations. Although many researchers investigated single deficiency of Fe or Zn, their interactions on biochemical and biological parameters are not clearly defined. We tried to determine the effect of dietary Fe and/or Zn deficiencies on rectal temperature, blood pressure, body water distribution, plasma erythropoietin level, blood biochemical parameters (lipids, protein and enzyme activity) and plasma mineral concentrations using experimental rats as a model for human zinc metabolism. Effects of combined deficiency of Fe and Zn were significantly different from those of single deficiency of Fe or Zn especially in body temperature. Body temperature was decreased by single deficiency of Fe or Zn, but combined deficiency of Fe and Zn did not change the temperature. Blood pressure is most decreased by combined deficiency of Fe and Zn, and plasma aldosterone concentration is also decreased by it. Fe and Zn deficiencies affect plasma Fe and Zn concentrations each other. Hence, future advancement of investigations on trace element interaction especially Fe and Zn is awaited.

著者

斉 悦 崔 懿 下城 千可 吉田 宗弘

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.26, no.1, pp.23-26, 2015-05-08 (Released:2015-05-28)

参考文献数

10

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To evaluate a validity of values for manganese (Mn) and molybdenum (Mo) contents of rice described in the Standard Tables of Food Composition in Japan 2010, 15 samples of Japanese brown rice, 53 samples of Japanese polished rice and 10 samples of Chinese polished rice were collected and their Mn and Mo contents were measured. Mean values of Mn in the Japanese brown rice and polished rice were 1.90 and 0.81 mg/100 g, respectively, which were close to values described in the Standard Tables. Mean value of Mn in the Chinese polished rice was 0.77 mg/100 g, which was also close to the values in the Standard Tables. Among the 53 samples of Japanese polished rice, 45 samples (84.9%) showed the Mn contents ranged from 0.6 to 1.0 mg/100 g. These results indicate that the Mn values of rice described in the Standard Tables are highly reliable. On the other hand, mean values of Mo in the Japanese brown rice and polished rice were 63 and 59 µg/100 g, respectively, which were also close to the Standard Tables. However, 42 samples (79.2%) of the Japanese polished rice showed the Mo content of less than 65 µg/ 100 g and a little sample showed more than 2 times of the values of the Standard Tables. Molybdenum contents in the Chinese rice showed higher values and variation than the Japanese rice. These results indicate that a large part of the Japanese rice showed a little lower Mo value than one described in the Standard Tables.

著者

中村 道子

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.1, pp.12-18, 2005 (Released:2006-07-05)

参考文献数

31

被引用文献数

2

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The trace elements play important roles in the human brain. The knowledge on the trace elements and neuropsychiatric disorders were comprehensively reviewed. These include iron, zinc, copper, iodine, lithium, aluminum, manganese, lead and mercury. Some metals have toxic actions on nerve cells and neurobehavioral functioning. The toxic actions could be expressed either as developmental effects or as an increased risk of neurodegenerative diseases in old age. Redox metals, which were iron, copper, and zinc in the brain, play many important roles in maintenance of cellular function.

著者

北條 慎太郎 深田 俊幸

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.23, no.1, pp.6-13, 2012 (Released:2012-10-01)

参考文献数

30

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Zinc (Zn) confers structure and catalytic functions to a number of enzymes and transcription factors, and its homeostasis is tightly controlled by Zn transporters (SLC39/ZIP: importers, SLC30/ZnT: exporters). Zn is an essential trace element, and its deficiency is associated with abnormal endocrine-system reactions leading to vertebral growth retardation and metabolic disorders. However, the molecular mechanisms by which Zn affects the endocrine system remain to be clarified. Here we examined the in vivo roles of SLC39A14, a member of the SLC39 family, by generating its deficient mice. The Slc39a14-knockout (KO) mice exhibit growth retardation accompanied by abnormal chondrocyte differentiation, reduced growth hormone production, and an impaired gluconeogenic program. We found that these phenotypes are attributable to impaired G-protein coupled receptor (GPCR)-mediated signaling, via the parathyroid hormone 1 receptor (PTH1R), growth hormone releasing hormone receptor (GHRHR), and glucagon receptor (GCGR), respectively, due to the degradation of cyclic adenosine monophosphate (cAMP) by the higher phosphodiesterase (PDE) activity in the Slc39a14-KO mice. Thus, the Zn transporter SLC39A14 is a new regulator for GPCR-mediated signaling for systemic growth.

著者

武田 憲昭

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.21, no.1, pp.32-37, 2010 (Released:2013-09-09)

参考文献数

22

被引用文献数

1

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We developed the ratio of apo/holo activities of angiotensin converting enzyme (ACE ratio) in the serum as an index of the zinc nutrition status. The zinc nutrition in patients with taste impairment was then estimated by dietary zinc intake, zinc concentration and ACE ratio in the serum. The results obtained in a series of our studies suggested that zinc deficiency is predominant factor underlying taste impairment even when zinc concentrations are within normal ranges in the serum and that ACE ratio is a more sensitive indicator of the zinc nutrition status than measuring zinc concentration in the serum. There were no differences of dietary intake of zinc after adjusting for energy and zinc concentration in the serum between patients and age-matched healthy subjects. But, ACE ratio in patients with taste impairment was significantly higher than that in age-matched healthy subjects. It is suggested that zinc deficiency in patients with taste impairment is due to malabsorption of dietary zinc from the duodenum and jejunum, but not low intake of dietary zinc.

著者

玉利 祐三 土屋 和幸

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.15, no.3, pp.248-258, 2004 (Released:2005-04-08)

参考文献数

20

被引用文献数

3

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Lithium content of the ocean fish has been investigated for estimating the intake of lithium, which was known as an element being used to a medicine (lithium carbonate) for the remedy of manic-depressive psychosis. In this study, fish (184 samples) was classified commercially into three types; raw fish (n=95), dry fish (n=70) and canned fish (n=19). Lithium content was determined by flame photometry after the decomposition of a fish sample (∼ 2g) with the mixture of nitric and perchloric acids. In the raw fish, lithium content was obviously higher in a sardine group (264 ± 186 ng/g in the range of 67 ∼ 934 ng/g, n=51) than in the other fish group (38 ± 28 ng/g in the range of 11 ∼ 86 ng/g, n=44, at wet-weight basis). Especially in the sardine group, the content was higher in anchovy (407 ± 167 ng/g, n=25) than in others (e. g., big-eye sardine; 85 ± 12 ng/g, n=11 and Japanese pilchard; 157 ± 43 ng/g, n=6, at wet-weight basis). In addition to the sardine group (anchovy, pilchard, sardine and blue sprat) rich lithium was found in the head (40 ∼ 66% of total lithium), compared with the eyes (0.1 ∼ 1%), internal organ (1 ∼ 9%), body (10 ∼ 33%) and back bone (15 ∼ 36%) of the fish. On the other hand, in dry fish, lithium was rich in the anchovy of “Niboshi” (5390 ng/g, as mean, n=30, at dry-weight basis) among dry sardine; manufactured as “Niboshi”, “Tazukuri”, “Maruboshi”, “Namaboshi” and “Chirimen” named for depending on their different drying-treatments in Japan. Lithium content of raw anchovy, 407 ± 167 ng/g (n=25) at wet-weight basis, was converted to 1770 ± 727 ng/g (n=25) at dry-weight basis, and the value was close to 2440 ± 657 ng/g (n=9) of dry anchovy as “Tazukuri” at dry-weight basis. The lithium content of canned sardine soaked with oil (sardine fillet: 246 ± 135 ng/g, n=15, at wet-weight basis) was close to that with water (sardine fillet: 123 ± 62 ng/g, n=3, at wet-weight basis), and was almost equal to that of raw sardine group (264 ± 186 ng/g, n=51, at wet-weight basis). It was concluded that anchovy and sardine, regardless of raw, dry or canned fish and of different ocean of the fish collected, were good material for the intake of lithium.

著者

金子 哲夫 山脇 奈見子

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.15, no.3, pp.235-242, 2004 (Released:2005-04-08)

参考文献数

28

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In Japan, Recommend Dietary Allowance (RDA) and Dietary Reference Intake (DRI) of trace elements were first specified in 1999. More than 4, 000 human milk samples were collected during 1998 and 1999 from Japanese lactating women at different postpartum and were individually analyzed for composition of nutrients including trace minerals. The latest data on zinc, copper, and selenium concentrations was summarized. The daily intake status of the trace elements by breast- and bottle-fed infants was investigated in reference to the 6th edition of RDA and DRI for Japanese nation.

著者

玉利 祐三

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.3, pp.250-257, 2005 (Released:2006-04-20)

参考文献数

26

被引用文献数

1

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Lithium carbonate is known as medical supplies for the remedy or prevention of manic-depressive psychosis. Blood lithium concentrations of their patients generally should be monitored during their hospital-treatments not to beyond the toxic concentration level of lithium. When heparin is usually added to a blood sample for preventing the blood-coagulation, impurity lithium of the reagent gives a positive error for the determination of lithium concentration of the blood. In this work the lithium concentration was determined by flame photometry after the decomposition of a sample with nitric-perchloric acids or hydrofluoric-nitric-perchloric acids for food samples. In the chemicals used for anticoagulant it was found that sodium citrate, heparin sodium salt and EDTA-2Na contained high amounts of lithium as impurity; 422, 221and 204 ng/g, respectively, whereas lithium was not detected in EDTA-4H and citric acid. Impurity lithium content of chemicals of general salt of sodium, potassium, magnesium and calcium were also tested; there was a fact that considerable amounts of lithium, 39500 and 14000 ng/g, existed in high purity of calcium metal and its carbonate. The Li/Ca ratio of the content of calcium salt (chemicals, n=36) was almost constant, and there was a good correlation between lithium and calcium content. The same tendency of the constant ratio of Li/Ca for the chemicals was also found in natural carbonate minerals of calcite, dolomite and aragonite, and biological materials of human milk, human serum, mammalian bone and oyster shell. On the other hand, lithium concentrations of plasma of healthy Japanese and Korean female were investigated, and the relationship between plasma lithium concentration and daily dietary lithium intake of the healthy people at urban district and village near seashore were also investigated in Korea. There was no significant difference between dietary lithium intake and plasma lithium concentration for the healthy people. Plasma lithium concentration was almost constant to be 11±2 ng/g (n=164) for healthy people.

著者

渡辺 和彦

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.20, no.4, pp.263-273, 2009 (Released:2013-09-09)

参考文献数

42

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On comparison of the concentration of elements between plants and humans, there are not significant differences in calcium and iron. However, the concentration of boron in plants is 140 times higher than that in humans, and that of silicon is 35 times higher. High concentrations of boron and silicon are included in agricultural products but not in fish or meat. Therefore, humans depend on vegetables and cereal crops in order to ingest silicon and boron. Since silicon and boron are useful for improving human bone density, it could be considered that the source of a healthy body rests with soil improvement agents and fertilizers used to grow agricultural products. Recently, however, the manganese, zinc and copper contents of the agricultural products in Japan are have decreased. Our research in Hyogo Prefecture has found that compost for organic cultivation alone does not supply elements due to the mechanism of microorganism, thereby reducing the concentration of manganese in plants. It is supposed that copper combines with organic matter and zinc becomes insoluble with phosphorus. Compost contains a lot of these trace elements, but they are not as available as we had expected. Efficient application methods for the trace elements including foliar and seed treatments have already been established. It is important to provide advice that these trace elements need to be applied to growing plants along with compost.

著者

川原 正博 水野 大

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.26, no.1, pp.10-22, 2015-05-08 (Released:2015-05-28)

参考文献数

71

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Increasing evidence suggests that dyshomeostasis of trace elements are implicated in the pathogenesis of various neurodegenerative diseases such as Alzheimer’s disease, prion diseases, and dementia with Lewy bodies. These diseases share similarity in the formation ofβ-sheet containing amyloid fibrils by disease-related proteins includingβ-amyloid protein (AβP), prion protein, α-synuclein, polyglutamine, and the introduction of apoptotic degeneration. Trace elements can bind to these proteins and cause their conformational changes. Furthermore, these proteins are co-localized in synapses and play crucial roles in the regulation of trace elements. Thus, it is possible that the interactions between the disease-related proteins and trace elements are based on the physiological roles of these proteins. We review here the current understanding of the pathology of the neurodegenerative diseases based on the metal-binding to disease-related proteins and on the disruption of metal homeostasis.

著者

小椋 康光

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.20, no.3, pp.240-246, 2009-10-01 (Released:2009-12-16)

参考文献数

18

被引用文献数

1

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Although selenium (Se) and tellurium (Te) are non-essential elements in plants, they are utilized in metabolic pathways to form the metalloid-containing compounds having carbon-metalloid covalent bond(s) (organic seleno/tellurometabolites). Therefore, it is necessary to identify seleno/tellurocompounds to determine the metabolic pathway of Se and Te, and understand the beneficial or toxicological effects of these compounds. Many literatures showed that the complementary use of HPLC-ICP-MS and HPLC-ESI (APCI)-MS/MS is a powerful tool for the speciation and identification of these metabolites. In this review, our recent works on the complementary use of ICP-MS, ESI-MS/MS and NMR from the viewpoint of identification of unknown seleno/tellurometabolites in plant samples were summarized. In particular, (1) speciation of sulfur (S) and Se-containing amino acids in Allium plants, (2) identification of a novel selenocompound in selenized Japanese pungent radish, (3) evaluation of function and translation efficacy of selenomethionine (SeMet)-containing proteins, (4) identification of SeMet-metabolites in wheat germ extracts, and (5) evaluation of Te metabolism in the Se-accumulating plant were mentioned.

著者

吉田 稔 久保 涼子 三迫 智佳子 鈴木 志乃舞 工藤 綾香 蜂谷 紀之 安武 章

出版者

一般社団法人 日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.24, no.3, pp.170-175, 2013 (Released:2013-10-29)

参考文献数

13

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This survey aimed to determine the levels of mercury in the scalp hair of residents of Hachinohe City in relation to their fish/seafood consumption to assess the risk of methylmercury exposure among the population. A total of 363 individuals (73 males and 290 females) residing in Hachinohe City (Aomori, Japan) provided scalp hair samples and completed a questionnaire. The geometric mean levels of mercury in the scalp hair were 2.52 and 1.91 μg/g in males and females, respectively, and 1.36 μg/g in females aged 15-49 years (n=80). The percentage of females of this generation with a hair mercury level above 2.2 μg/g (corresponding to the WHO's provisional tolerable weekly intake for methylmercury) was 21%, which was lower than the mean of 25% for residents of 10 regions across Japan. The Hachinohe residents consumed a mean of 108 g/day of fish/seafood (which was higher than the mean of 80.2 g/day for the overall Japanese population), consisting mainly of salmon, squid, mackerel, saury, and Atka mackerel. These results demonstrated that the hair mercury level of the residents of Hachinohe City was not so high as the higher consumption of fish/seafood compared with the national average, indicating that the risk of methylmercury exposure through increased fish/seafood consumption among Hachinohe City residents is not particularly high compared with the national level.

著者

小谷 明

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.22, no.1, pp.22-26, 2011 (Released:2013-09-09)

参考文献数

13

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Cisplatin, clinically used anticancer Pt(II) complex, has been believed to attack DNA to form Pt-N7(Guanine) coordination, and Pt-G bond is protected from DNA repair enzyme by the aromatic ring stacking between Pt-G and Phe side chain in Pt-DNA-HMG protein adduct. The adduct mimicked 4N coordinated Pt(II) complexes M(DA)(AtCn) involving with metal coordinated aromatic diamine (DA) and anthracene ring side chain in AtCn, which could not coordinate DNA, showed not only in vitro cytotoxicity for human cancer cell lines but also strong inhibition with protein interaction such as the proteasome. The bio-activity indicated the structural dependence of both DA and AtCn. This should relate with the intramolecular aromatic ring stacking interaction which was evidenced by the X-ray structure in crystal and the H-1 NMR in H2O solution. Importantly the Pt(II) complexes showed similar bioactivity in cisplatin resistance cancer cell. These experimental results showed that the Pt complexes involving stacking structure might be new type anticancer metal compounds.

著者

山下 倫明 今村 伸太朗 藪 健史 石原 賢司 山下 由美子

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.24, no.4, pp.176-184, 2013 (Released:2014-01-22)

参考文献数

51

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Selenium is an essential micronutrient for humans, and seafood is one of the major selenium source in Japan. Recent studies show that the tissues of tuna and other predatory fish contain high levels of the selenium-containing imidazole compound, 2-selenyl-Nα, Nα, Nα-trimethyl-L-histidine (selenoneine). A substantial proportion of the total amount of selenium is present as selenoneine in the muscles of ocean fish. Selenoneine contains an imidazole ring with a unique selenoketone group and has an antioxidant activity in vitro and in vivo. The dietary intake of selenoneine through fish consumption is thought to be important for enhancing selenium redox functions in tissues and cells. In addition, selenoneine accelerated the excretion and demethylation of methylmercury through the formation of secretory extracellular lysosomal vesicles via the specific organic cation/carnitine transporter-1 (OCTN1). Dietary intake of selenoneine might decrease the formation of hydroxyl and other radicals and accelerate the excretion of heavy metals, and thereby inhibit carcinogenesis, lifestyle chronic diseases, and aging.

著者

倉澤 隆平 久堀 周治郎 奥泉 宏康

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.21, no.1, pp.1-12, 2010 (Released:2013-09-09)

参考文献数

13

被引用文献数

1

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It is well known that zinc is an essential trace element for maintaining human health. However, there is a paucity of literature describing cases of zinc deficiency, leading many physicians to believe that zinc deficiency is a rare occurrence. Nevertheless, we have found many zinc-deficient patients at our Kitamimaki-onsen clinic since 2002, and reported their symptoms at the annual meeting of this BRTE society held in 2005. Their complaints were anorexia, general fatigue, impaired sense of taste, burning mouth, various types of skin lesion, delayed wound healing, emotional instability, and others. Each of these wide ranging complaints can be induced by zinc depletion, though they do not necessarily manifest themselves simultaneously. The reasons why such a wide range of symptoms appear in cases of zinc deficiency are becoming more apparent, due to recent studies advancing our knowledge on the functions of zinc-related proteins such as zinc transporters and zincrelated metaloenzymes. In this paper, we offer possible explanations on the relationship between zinc depletion and the onset of the abovenoted symptoms, and discuss the limitations of using serum zinc levels to detect and diagnose zinc deficiency.