- 著者
- 山本 (前田) 万里 永井 寛 江間 かおり 神田 えみ 岡田 典久 安江 正明
- 出版者
- 公益社団法人 日本食品科学工学会
- 雑誌
- 日本食品科学工学会誌 (ISSN:1341027X)
- 巻号頁・発行日
- vol.52, no.12, pp.584-593, 2005 (Released:2007-04-13)
- 参考文献数
- 31
- 被引用文献数
- 8 9
A double-blind clinical study was carried out on subjects with Japanese cedar pollinosis for the evaluation of the effects and safety of ‘Benifuuki’ green tea, which contains epigallocatechin-3-O-(3-O-methyl)-gallate (O-methylated catechin), and a combination of ‘Benifuuki’ green tea and ginger extract, with ‘Yabukita’ green tea as a placebo. First, the effect of the combination of ‘Benifuuki’ green tea and various vegetable extracts on cytokine production inhibition was investigated using mast cells ; the simultaneous use of ‘Benifuuki’ green tea and ginger extract was found to suppress cytokine (TNF-α or MIPI-α) production to a remarkable extent. Subjects were given 1.5 g of ‘Benifuuki’ green tea, ‘Benifuuki’ green tea containing 30 mg of ginger extract, or ‘Yabukita’ green tea with water twice every day for 13 weeks. As cedar pollen scattering increased, the severity of pollinosis symptoms among the groups was observed to increase in the following order : placebo group>’Benifuuki’ group>’Benifuuki’ and ginger group. Eleven weeks after the beginning of treatment, during the most severe cedar pollen scattering period, symptoms of runny nose and itchy eyes were significantly relieved among the ‘Benifuuki’ group compared with the placebo group (p<0.05). In the ‘Benifuuki’ and ginger group, runny nose, itchy eyes and nose symptom scores were significantly reduced at the eleventh week, and nasal congestion, sore throat and nose symptom medication scores were significantly reduced at the thirteenth week compared with the placebo group. Among all test groups, hematological examination, general biochemical examination, determination of total IgG, CMV antibody titer, and serum iron content, and interviews throughout the intake period found no changes related to clinical problems. These results suggest that intake of ‘Benifuuki’ green tea over one month is useful in reducing some of the symptoms of Japanese cedar pollinosis, and did not affect normal immune response in subjects with Japanese cedar-pollinosis. It was also found that the addition of ginger extract enhanced the effect of ‘Benifuuki’ green tea.
1 0 0 0 OA バナジウム含有天然水の糖尿病改善作用における考察
- 著者
- 渋市 郁雄 安江 正明 加藤 克彦 渡邉 泰雄
- 出版者
- 日本微量元素学会
- 雑誌
- Biomedical Research on Trace Elements (ISSN:0916717X)
- 巻号頁・発行日
- vol.17, no.1, pp.11-16, 2006 (Released:2006-09-13)
- 参考文献数
- 24
- 被引用文献数
- 1
This paper argues the possible effects of natural vanadium-containing Mt. Fuji ground water on the hyperglycemia based on our previously reported animal and clinical studies. In the animal studies, we documented that the activities of liver insulin receptors, particularly β subunit, and primary insulin-like growth factor-1 β were recovered to the normal levels by the daily forced oral treatment with Mt. Fuji ground water containing natural vanadium in Goto-Kakisaki (GK) rat which is the genetic model of Type II diabetes. Furthermore the increased levels of blood glucose and serum hemoglobin A1C (HbA1C) of GK rats were significantly blocked by the consecutive treatment of natural vanadium water. It is interesting that the other genetic model of Type II diabetes, KKAy mice, were likely to be shown the inhibitory effects of the consecutive treatment of natural vanadium water on increases of blood glucose but not significant. In these animals, however, the significant improvements of Glut 4 transporter and receptor activities in the adipose and muscle were detected. In the clinical studies, the levels of blood glucose and serum HbA1C of hyperglycemic patients were significantly reduced by three month consecutive treatment of this Mt. Fuji ground water, and also the QOL of these patients were completely improved, although these effects were clearly affected by the changes in each life style. Thus both animal and human studies suggest that the daily treatment with Mt. Fuji ground water containing natural vanadium is useful for the regulation of blood glucose levels and the improvement of QOL to the hyperglycemia patients due to the improvements of glucose transporter and the insulin receptor and so on. However it might be little difficult to expect the significant improvement of the severe conditions of diabetes mellitus by the consecutive treatment of natural vanadium water, since this ground water is good as a supplement.
- 著者
- 灘岡 勲 安江 正明 大竹 康之 武田 恭一 松本 一浩 柿野 克自 多田 由実
- 出版者
- 日本補完代替医療学会
- 雑誌
- 日本補完代替医療学会誌 (ISSN:13487922)
- 巻号頁・発行日
- vol.3, no.1, pp.15-22, 2006 (Released:2006-03-09)
- 参考文献数
- 24
我々は大豆イソフラボンとブラックコホシュエキスを含む健康食品の更年期女性の SMI に対する臨床有用性について,二重盲験試験により検討した.24 名の閉経前後の女性対象者を 2 つのグループに分け,試験食品もしくはプラセボを毎日 4 カプセルずつ,8 週間経口摂取させた.1 日あたりの摂取量は,大豆イソフラボン 50.0 mg,ブラックコホシュエキス 80.0 mg であった.試験食品摂取群ではプラセボ摂取群と比較して,「肩こり,腰痛」の更年期障害スコアが有意に改善 (p<0.05) され,さらに「イライラ」のスコアにおいては統計学的に有意ではないが改善の傾向が確認された.試験食品摂取前の更年期障害重症度による層別解析の結果,試験食品の効果は症状の軽い被験者においてより顕著であった.これらの結果より,大豆イソフラボンとブラックコホシュエキスを含む健康食品は更年期の不定愁訴を緩和し,生活の質の向上に有用であることが示された.
- 著者
- 灘岡 勲 安江 正明 大竹 康之 武田 恭一 松本 一浩 柿野 克自 多田 由実
- 出版者
- 日本補完代替医療学会
- 雑誌
- 日本補完代替医療学会誌 (ISSN:13487922)
- 巻号頁・発行日
- vol.3, no.1, pp.15-22, 2006
我々は大豆イソフラボンとブラックコホシュエキスを含む健康食品の更年期女性の SMI に対する臨床有用性について,二重盲験試験により検討した.24 名の閉経前後の女性対象者を 2 つのグループに分け,試験食品もしくはプラセボを毎日 4 カプセルずつ,8 週間経口摂取させた.1 日あたりの摂取量は,大豆イソフラボン 50.0 mg,ブラックコホシュエキス 80.0 mg であった.試験食品摂取群ではプラセボ摂取群と比較して,「肩こり,腰痛」の更年期障害スコアが有意に改善 (p<0.05) され,さらに「イライラ」のスコアにおいては統計学的に有意ではないが改善の傾向が確認された.試験食品摂取前の更年期障害重症度による層別解析の結果,試験食品の効果は症状の軽い被験者においてより顕著であった.これらの結果より,大豆イソフラボンとブラックコホシュエキスを含む健康食品は更年期の不定愁訴を緩和し,生活の質の向上に有用であることが示された.<br>