著者

田島 邦好 前川 隆 今井 庸二 能勢 之彦

出版者

一般社団法人 日本人工臓器学会

雑誌

人工臓器 (ISSN:03000818)

巻号頁・発行日

vol.2, no.1, pp.38-46, 1973-02-15 (Released:2011-10-07)

参考文献数

22

被引用文献数

2

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The cardiac prosthesis utilizing biological tissue has been developed and reported (ASAIO 1971). Bovine aortic valves and pericardium preserved in formardehyde solution for 1 week were used as the inside surface of the device and outside was reinforced by specially treated natural rubber.In the study described here the thromboresistant properties and hemodinamic performance of the device with inflow and outflow valves were evaluated in vitro and in vivo studies.Both in in vitro Kinetic blood Clotting method and intra-thoratic aortic bypass implantation the biolized surface showed excellent antithrombogenecity. One out of 9 calves in which the device was implanted in aorta is still alive 20 months after implantation and device is showing good patency without any evidence of thromboembolism.From the view point of hemodinamic performance the device revealed a similar Starling's reguration to natural heart in a mock system and performed enough cardiac output to keep the animal alive up to 16l/min.Total heart replacement with this cardiac prosthesis have been done in calves intrathoracically. One of them survived 17 days (408 hours) after implantation. The Calf stood up and walked around by himself and took foods and drinks. Couse of death was ruptur of the device in this case.Further study is needed to investigate the endurance of this biolized heart as well as its effect on the body.