2 0 0 0 OA X線応用3次元加工用シミュレーションシステムの開発
- 著者
- 平井 義和 Sadik Hafizovic Jan G. Korvink 田畑 修
- 出版者
- 一般社団法人 電気学会
- 雑誌
- 電気学会論文誌E(センサ・マイクロマシン部門誌) (ISSN:13418939)
- 巻号頁・発行日
- vol.123, no.9, pp.368-375, 2003 (Released:2003-12-01)
- 参考文献数
- 10
- 被引用文献数
- 3 3
We have developed an X-ray lithography simulation system X3D (Moving Mask Deep X-ray Lithography Simulation System for 3-Dimensional Fabrication) for the first time, that is tailored to simulate the fabrication process of 3-dimensional microstructures using the M2DXL (Moving Mask Deep X-ray Lithography) technique. The newly developed X3D can simulate the progress of developed PMMA surface with developing time using chemical dissolution rate data as a function of dose energy. The simulation system consists of three modules: mask generation, exposure, and development. The exposure module calculates a dose energy distribution over a PMMA using a mask pattern and its movement pattern, and then converts this dose energy to a dissolution rate of PMMA. The development module adopted a "Fast Marching Method" to calculate the resultant 3D shape of the PMMA. In this paper, a new experimental method to determine dissolution rate as a function of dose energy that dominates the simulation accuracy was proposed. An experimental procedure of the new experimental method, the determined dissolution rate, and verification of the measured results are presented.
1 0 0 0 OA マイクロマシニング技術の課題と展開
- 著者
- 田畑 修
- 出版者
- 一般社団法人 日本生体医工学会
- 雑誌
- BME (ISSN:09137556)
- 巻号頁・発行日
- vol.12, no.4, pp.58-65, 1998-04-10 (Released:2011-09-21)
- 参考文献数
- 9
1 0 0 0 3次元微細加工を応用したBody on a Chipの開発
- 著者
- 加藤 義基 平井 義和 亀井 謙一郎 土屋 智由 田畑 修
- 出版者
- 一般社団法人 電気学会
- 雑誌
- 電気学会論文誌E(センサ・マイクロマシン部門誌) (ISSN:13418939)
- 巻号頁・発行日
- vol.136, no.6, pp.229-236, 2016-06-01 (Released:2016-06-01)
- 参考文献数
- 34
In vitro cell-based assay with human cells is getting attention since the accuracy of preclinical predictions of drug responses should be improved to reducing costly failures in clinical trials. In order to generate reliable predictions, we present a micro-engineered biomimetic systems “Body-on-a-Chip”, to investigate the effects of drugs/metabolites on various organs by assembling a closed-loop medium circulation system on one microfluidic device. For three-dimensional (3-D) polymeric device fabrication, an advanced 3-D lithography with the process optimization method is applied to improve the current soft-lithography technique. Our Body-on-a-Chip is successfully applied to evaluate the effect of an anti-cancer drug (doxorubicin) on cell survival of human heart and liver cells.