著者

福本 恭子

出版者

大阪市立大学経営学会

雑誌

経営研究 (ISSN:04515986)

巻号頁・発行日

vol.62, no.3, pp.125-141, 2011-11

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1 はじめに : 近年における産業構造の変化、技術革新の進展等、労働者をとりまく環境が大きく変化しており、食生活についても飽食やグルメ時代などと言われるように豊かになっている。そのような中で、わが国の栄養状況は、個々の世帯や個々人で見たとき、過剰な栄養摂取や運動不足、アンバランスな栄養の摂取等から発症される生活習慣病といわれる疾病が増加しており、社会的な問題となっている。厚生労働省は、第11次労働災害防止計画において「労働者の安全と健康の確保」をかかげ、労働者に対して正しい食生活の知識と実践に必要な技術を普及し、労働者の食生活の向上をはかる必要性を唱えている。……

著者

小林 貴志 福本 恭子 土下 喜正 楠本 正明 上野 和行

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.32, no.8, pp.772-775, 2006-08-10 (Released:2007-11-09)

参考文献数

11

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It has been reported that the pharmacokinetics and pharmacodynamics of carvedilol vary between the S- and R- enantiomers. The aim of this study was to evaluate the pharmacokinetic characteristics of carvedilol for each enantiomer and apply this in clinical practice. Serum stereoselective concentrations of carvedilol were monitored in 60 Japanese inpatients who received a fixed dose of carvedilol. The concentrations were determined by high performance liquid chromatography (HPLC). Serum carvedilol concentration/dose of administered carvedilol ratios were determined for each enantiomer (R/D, S/D). The means±SD for R/D and S/D were 85.8±264.0 (10-3kg/L) and 29.0±78.2 (10-3kg/L), respectively. The mean for R/D tended to be larger than that for S/D (p=0.11), and the dispersion of R/D was significantly greater than that of S/D (p<0.01). Although a significant positive correlation was observed between R/D and S/D, a remarkable difference was observed in a few inpatients. These results suggest that the pharmacokinetics of carvedilol are different for each enantiomer. The monitoring of the stereoselective pharmacokinetics of carvedilol is therefore necessary to ensure proper use.

著者

上野 和行 福本 恭子 三星 知 本田 裕加 五十嵐 幸子 長井 一彦 岡島 英雄

出版者

日本食生活学会

雑誌

日本食生活学会誌 (ISSN:13469770)

巻号頁・発行日

vol.25, no.2, pp.101-104, 2014 (Released:2014-10-30)

参考文献数

11

被引用文献数

1 1

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The Effects of a brown rice diet on clinical laborator y data in cholesterolemia patients (n=20, 2 men and 18 women) were studied. They had been diagnosed with cholesterolemia having over a 180 mg/dL total cholesterol level and received HMG-CoA reductase inhibitors for treatment of their cholesterolemia. All of the patients usually ingested a polished rice diet. They ingested a brown rice diet instead of a polished one 2 out of 3 meals ( breakfast, lunch and dinner ) for 3 months. The mean levels of the total cholesterol and LDL-cholesterol after the study had significantly decreased more than those before the stud y. There was a tendency that the triglyceride after the study had decreased. Also, the mean levels of serum creatinine and blood urea nitrogen after the study had significantly decreased more than those before the study. These results suggested that the ingestion of a brown rice diet suppor ts health care by improving lipidsis in cholesterolemia.