- 著者
- 藤田 貢 洪 卿秀 伊東 八重 三沢 悟 竹内 尚人 仮家 公夫 西室 悟司
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.18, no.9, pp.1194-1196, 1995-09-15 (Released:2008-04-10)
- 参考文献数
- 11
- 被引用文献数
- 47 72
Intraduodenal administration of nattokinase (NK) at a dose of 80mg/kg, resulted in the degradation of fibrinogen in plasma suggesting transport of NK across the intestinal tract in normal rats. The action of NK on the cleavage of fibrinogen in the plasma from blood samples drawn at intervals after intraduodenal administration of the enzyme was investigated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting analysis with an anti-fibrinogen γ chain antibody. The 270 kDa fragment carrying antigenic sites for the binding of the anti-fibrinogen γ chain antibody appeared within 0.5h and was then degraded gradually to a 105kDa fragment via a 200 kDa fragment. This suggests that fibrinogen was degraded to a 105 kDa fragment via several intermediates (270 and 200kDa). In parallel with the degradation process, plasma recalcification times were remarkably prolonged. NK was also detected in the plasma from blood samples drawn 3 and 5 h after administration of the enzyme by SDS-PAGE and Western blotting analysis with an anti-NK antibody. The results indicate that NK is absorbed from the rat intestinal tract and that NK cleaves fibrinogen in plasma after intraduodenal administration of the enzyme.
1 0 0 0 OA 超低電力マイクロプロセッサの実現に向けた 断熱型磁束量子パラメトロンの進展
- 著者
- 竹内 尚輝
- 出版者
- 公益社団法人 低温工学・超電導学会 (旧 社団法人 低温工学協会)
- 雑誌
- 低温工学 (ISSN:03892441)
- 巻号頁・発行日
- vol.52, no.5, pp.332-339, 2017-09-20 (Released:2017-10-27)
- 参考文献数
- 53
- 被引用文献数
- 1 1
We report recent progress on adiabatic quantum-flux-parametron (AQFP) logic, which is an energy-efficient superconductor logic based on quantum flux parametron (QFP). The switching energy of an AQFP gate can be arbitrarily reduced via adiabatic switching, in which the shape of the potential energy gradually varies between single-well and double-well shapes as the result of using ac excitation magnetic fluxes. First, we show the operation principle of AQFP and explain adiabatic switching in light of potential energy shapes. We also show calculated switching energy and bit error rates to demonstrate that the switching energy of AQFP can be significantly reduced while keeping a low error rate. Then, we report recently developed AQFP subsystems, which include an 8-bit carry look-ahead adder, a register file, and a long-interconnect driver. Our demonstration reveals that AQFP technology is ready to be applied in microprocessor design.
- 著者
- 岡本 耕一 岡村 誠介 井本 佳孝 木村 哲夫 竹内 尚 宮本 弘志 四宮 寛彦 岡久 稔也 和田 哲 高山 哲治
- 出版者
- 一般社団法人 日本消化器内視鏡学会
- 雑誌
- 日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy (ISSN:03871207)
- 巻号頁・発行日
- vol.54, no.2, pp.260-266, 2012-02-20
- 参考文献数
- 13
症例は63歳,女性.検診にて異常を指摘され当科に紹介された.内視鏡検査にて十二指腸球部に細長い突起物を認め,内視鏡的ポリペクトミーを行った.この突起物は,病理組織学的に正常十二指腸粘膜で覆われBrunner腺の増生と拡張した静脈を有する粗な粘膜下組織を認め,内部に大小の嚢胞状に拡張した腺が認められた.本症例は稲本らやEzoeらにより提唱されたintraluminal duodenal protrusionやElongated non-neoplastic duodenal polypなる概念に相当するものと考えられた.
