著者

藤巻 可弓 荒川 千夏子 吉永 淳 渡辺 知保 芹澤 滋子 今井 秀樹 白石 寛明 水本 賀文

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.59, no.4, pp.403-408, 2004-11-15 (Released:2009-02-17)

参考文献数

14

被引用文献数

14 21

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Objective: The daily bisphenol A (BPA) intake level of Japanese pregnant women was surveyed based on the measurement of the urinary excretion level of a BPA metabolite.Methods: Spot urine samples were collected from 56 pregnant women who visited the gynecology division of a hospital for a routine health check between June and October 2003. The urinary concentrations of the BPA metabolite and creatinine were measured by GC/MS/MS and spectrophotometry, respectively. Daily BPA intake was assumed to be equal to daily excretion.Results: The daily intake of BPA among Japanese pregnant women was estimated to be in the range of <0.3 to 7.9μg/day (median<2.0μg/day), being consistent with the levels in previous studies for non-pregnant Japanese women. This level was far below the current Acceptable Daily Intake (0.01mg/kg/day) which was set by the European Commission. The maximum estimated intake per body weight (0.16μg/kg/day) reached 1/10 of the Lowest Adverse Effect Level of BPA for pregnant mice for a reproductive effect on the offspring (2μg/kg/day).Conclusion: It is desirable to lessen BPA intake from a precautionary viewpoint, particularly in pregnant women.