1 0 0 0 IR Tropone-誘導体の制癌作用について
- 著者
- 中尾 英雄 福島 正美 清水 総明 荒川 順生
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.94, no.8, pp.1032-1037, 1974-08-25 (Released:2008-05-30)
- 参考文献数
- 6
- 被引用文献数
- 12 14
Water-soluble derivatives of N-(2-chloroethyl)-N-nitrosourea were synthesized and their antitumor activity was tested against leukemia L-1210. Most of these compounds showed a high activity.
- 著者
- 中尾 英雄 荒川 順生 中村 隆洋 福島 正美
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.20, no.9, pp.1968-1979, 1972-09-25 (Released:2008-03-31)
- 被引用文献数
- 24 31
A series of 2, 5-bis (1-aziridinyl)-p-benzoquinone derivatives were synthesized and evaluated as antileukemic agents. The most active compounds against lymphoid leukemia L-1210 in BDF1 mice were 2, 5-bis (1-aziridinyl)-3-(2-carbamoyloxyethyl-1-methoxy)-6-methyl-p-benzoquinone, carbazilquinone (7), and related compounds (8, 23 and 24). Structure-activity relationships were discussed.
- 著者
- 中尾 英雄 荒川 順生
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.20, no.9, pp.1962-1967, 1972-09-25 (Released:2008-03-31)
- 被引用文献数
- 8 13
A series of p-benzoquinone derivatives having one or two carbamoyloxyalkyl groups in the 2 and/or 5-positions were synthesized and evaluated as antileukemic agents. Among these compounds 2, 5-bis (1-aziridinyl)-3-(2-carbamoyloxyethyl)-6-methyl-p-benzoquinone (21) showed high activity against lymphoid leukemia L-1210 in BDF1 mice.