著者

村田 亮 黒田 重史 石毛 徳之 荻野 修平 三笠 元彦

出版者

日本肩関節学会

雑誌

肩関節 (ISSN:09104461)

巻号頁・発行日

vol.36, no.3, pp.1015-1018, 2012 (Released:2012-10-25)

参考文献数

11

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Background: The scapula rotates upwardly during shoulder elevation. If the rotation center wasn't fixed on the scapula but on the humeral head, the movement of the glenoid would be regarded as the rotation along the humeral head. We have analyzed throwing shoulder injury cases using this concept of “functional glenoid”.Methods: Patients with throwing shoulder injury (TSI group; n=22) and normal control (n=8) were included in the study. Two radiographs were taken of each subject (anteroposterior in internal rotation; IR1, zero position). Two straight lines were drawn from the superior and inferior tubercle to the center of the humeral head in IR1 image, and the angle of the lines was measured (α angle). The TSI group was divided to two groups according to slipping of the humeral head in zero position images. The difference of the glenoid inclination angles between IR1 and zero position (β angle) were then measured, and the glenoid extension ratio (α+β/α) was calculated. Each set of data was statistically evaluated.Results: In the TSI group, β angle and the glenoid extension ratio did not show significant difference compared to the control group, but the slipping-negative cases showed significantly larger β angle than slipping-positive cases and the control group.Discussion: These results may be derived from multifactorial pathology of throwing shoulder injury. Significantly large β angle in slipping-negative TSI cases may indicate an adaptive pattern of movement of the scapula. The glenoid extension ratio could not reflect the scapular kinematic change of throwing shoulder injury.

著者

菅原 満 荻野 修 宮崎 勝巳

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.3, pp.256-258, 2002-06-10 (Released:2011-03-04)

参考文献数

4

被引用文献数

2 1

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Zyvox® (linezolid), an oxazolidinone-class synthetic antibacterial agent, has been approved for the treatment of vancomycin-resistant Enterococcus faecium infections. Although there are three forms of this drug, including injection, tablets and oral suspension, presently available overseas, only injection and tablets have so far been approved in Japan. It is possible to use ground tablets as an oral suspension. However, the quality including the stability of linezolid in such a suspension has not yet been studied. In this study, we therefore, examined the stability of linezolid in a suspension of ground tablets and the characteristics of such a suspension. The solubility of linezolid was low, and approximately 85% of linezolid was suspended in a solid phase. Linezolid was stable in the suspension, and there were no differences in the pH for up to 24 hours. However, precipitation occurred rapidly after the ground tablets had been suspended. The concentration of linezolid in the upper layer of the suspension decreased to half of the initial concentration in 15 min.In conclusion, Zyvox® was found to be stable and therefore is considered suitable to be ground and used in an oral suspension. Such suspensions should be re-suspended just before use, especially when the suspension is pre-constituted.

著者

武隈 洋 岩井 美和子 藤原 俊恵 川岸 亨 熊井 正貴 松浦 麻耶 馬渕 朋美 須田 範行 宮本 剛典 荻野 修 菅原 満 宮崎 勝巳

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.31, no.7, pp.575-584, 2005-07-10

被引用文献数

5 6

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The results of cancer chemotherapy have been improved remarkably by the development of new drugs and combining drugs in treatment. However, cancer chemotherapy protocols are complicated and the adverse effects are more severe than those of other pharmacotherapies. It was therefore felt important to create a database of protocols for the preparation and dispensing of drugs used in cancer chemotherapy. Using Microsoft Access, we have created a database from 320 protocols we have collected so far from 12 clinical departments and developed operating programs for it. The database has enabled us to search for a protocol using keywords-names of drugs, diseases and clinical departments-and most of the operations can be carried out by the click of a mouse. With our database, pharmacists are able to access protocols quickly and check prescriptions of anticancer drugs even if they are unfamiliar with computers, and we consider it to be a useful tool for this purpose.