著者

今井 俊吾 阿部 真也 松井 洸 柏木 仁 佐藤 夕紀 武隈 洋 吉町 昌子 菅原 満

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.24, no.2, pp.75-87, 2022-08-31 (Released:2022-10-11)

参考文献数

17

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Objective: In our previous study, we revealed that articles on "dangerous drugs" in weekly magazines are inadequate and incomplete with respect to scientific validity, and that there may be many aspects that need to be improved. Next, the extent to which medical professionals, including doctors, pharmacists, and nurses, received consultations by patients owing to such media reports and what countermeasures are implemented requires clarification. In the present study, as a first step, we performed a questionnaire survey of community pharmacists to clarify the occurrence of such consultations.Methods: A questionnaire survey was conducted among 698 community pharmacists. The survey was conducted over 10 days from December 8 to 17, 2021.Results: Out of the 698 community pharmacists, 545 responded (response rate: 78.1%). Of these, 323 (59.3%) had experienced consultations from patients owing to media reports on the dangers of drugs. Of the 323 respondents, 215 (66.6%) had experienced these consultations less than five times. In contrast, 83 respondents (25.7%) reported more than 10 such consultations. Of the 545 respondents, 190 (34.9%) responded that they routinely perform measures to deal with media reports on the dangers of drugs. The most common routine measure was the "regular checking of various media sources (including preparation of responses when receiving consultation requests)."Conclusion: Our results indicated that more than half of the community pharmacists had experienced receiving consultations from patients, although only approximately 30% were adopting routine measures. This suggests that community pharmacists have been affected to some extent by these media reports, and that further countermeasures need to be implemented.

著者

今井 俊吾 柏木 仁 佐藤 夕紀 武隈 洋 菅原 満

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.24, no.1, pp.1-10, 2022-05-31 (Released:2022-06-11)

参考文献数

11

被引用文献数

1

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Objective: Recently, special features on “dangerous” prescription drugs have been frequently published in few mass media platforms, such as weekly magazines. However, to our knowledge, there have been no prior studies, systematically organizing and evaluating the contents of these articles (e.g., drugs and their side effects that are reported). In this study, we aimed to evaluate the relevance of the information on “dangerous drugs” that was published in weekly magazines using the modified “Media Doctor” instrument.Methods: We extracted articles on “dangerous” prescription drugs from 10 weekly magazines for which the table of contents of previous issues are available on their official websites. Information regarding the target drugs and their classifications was compiled and organized. The relevance of the extracted news articles was assessed by two independent evaluators. The evaluation index was based on the modified “Media Doctor” instrument, and 9 evaluation criteria were used to assign the following categories: satisfactory, unsatisfactory, or not applicable.Results: A total of 1,064 articles were screened, and 19 articles were selected for further evaluation. A total of 179 drugs (belonging to 34 drug classes) were listed. The most frequently mentioned class of drugs included hypnotics and sedatives, and the most frequently listed was triazolam. Of the 19 articles, 11 had zero items that were judged satisfactory by both the evaluators. The number of unsatisfactory items was widely distributed, but in 11 of the 19 articles, five and more items were judged unsatisfactory by both the evaluators.Conclusion: We revealed that a wide variety of drugs have been termed as “dangerous” by weekly magazines. Additionally, we found that these articles were inadequate and incomplete with respect to scientific validity, and that there are many aspects that require further improvement.

著者

今井 俊吾 難波 正志 柏木 仁 佐藤 夕紀 武隈 洋 菅原 満

出版者

一般社団法人 日本薬局学会

雑誌

薬局薬学 (ISSN:18843077)

巻号頁・発行日

pp.nt.2020-0025, (Released:2021-03-10)

参考文献数

10

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薬剤師は安全な薬物療法の提供のために,患者から必要な情報を「聞き取る」ことが重要である.しかし,薬局薬剤師の「聞き取り」に対し,一部の一般市民は厳しい視線を投げかけており,患者の理解を促すためのエビデンス構築が急務である.本研究は「患者への聞き取り」に基づき実施された疑義照会に着目し,その実態解明と医療安全への貢献度評価を試みた.解析には北海道大学病院の近隣薬局の疑義照会データを用いた.その結果,聞き取りに基づく疑義照会は「薬学的疑義照会の 33.3%を占め,高い許諾割合(98.5%)を有し,用法や用量などの疑義照会分類において,医療安全への貢献度が高い」ことが見いだされた.また,このうち「医師からの説明と処方内容が食い違う」ことが発端となった事例が,特に医療安全へ貢献していることが示された.「患者への聞き取り」に基づく疑義照会の有用性を広く調査するための基礎となる知見が創出された.

著者

武隈 洋 高地 里佳 石坂 悠 佐藤 夕紀 鷲見 正人 菅原 満

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.3, pp.135-146, 2014-03-10 (Released:2015-03-10)

参考文献数

20

被引用文献数

3

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This study determined the effects of long-term storage under various conditions after opening press through package (PTP) sheets on the stability of each tablet formula of statin for treatment of dyslipidemia and clarified the difference in stability between brand-name drugs and generic drugs.It was demonstrated that opened Crestor® tablets were stable for one year under the conditions of diffused light at room temperature and shielded light at room temperature. Although the content of rosuvastatin in ground Crestor® tablets was greatly decreased after only 1 month under the condition of diffused light, it was stable for at least 3 months under shielded light, indicating that shielded light is necessary for storage of ground Crestor® tablets. Of the four tablet formulae of simvastatin tested, only Lipola®M was within the stability standards after storage for 6 months under all conditions. The other tablet formulae of simvastatin showed changes in hardness or elution pattern even under the condition of shielded light at room temperature, indicating that care is needed in preparing one-dose packages of these formulae. Four tablet formulae of pravastatin used in this study were stable for 6 months under shielded light at room temperature. It was also found that three of the five formulae with decreasing elution velocity contained crospovidone and that the other formulae contained no crospovidone. This decrease in elution velocity appears to be due to reduction in porosity of the tablet caused by high humidity.

著者

小林 洋平 山岡 怜央 三上 龍生 山崎 浩二郎 熊井 正貴 山田 武宏 武隈 洋 菅原 満 井関 健

出版者

一般社団法人 日本臨床救急医学会

雑誌

日本臨床救急医学会雑誌 (ISSN:13450581)

巻号頁・発行日

vol.23, no.6, pp.771-779, 2020-12-28 (Released:2020-12-28)

参考文献数

14

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目的:救急/ 集中治療室(以下,ICU)における薬剤師介入の実態や医療経済効果を明らかにすることを目的とした。方法:2017年7,8月に,救急科に入院した患者を対象とし,疑義照会記録を用いて後方視的に調査した。薬学的知識を要しない介入を単純エラー,薬学的知識を要する介入を薬学的介入と定義し,介入の内容および処方反映率を調査した。また,能動的な薬学的介入(薬剤師からの提案)に関して医療経済効果を算出した。結果:介入は391件あり,そのうち76%(297件)が薬学的介入であった。薬学的介入では,抗微生物薬関係の介入がもっとも多く117件(反映率91%)であった。また,医療経済効果は,2カ月間で3,832,000 円であった。結論:薬剤師の救急/ICUへの参画は,医療経済的に有益であることが明らかとなった。また抗微生物薬関係の介入が多く,今後プロトコル作成などにより適正使用推進に寄与できると示唆された。

著者

今井 俊吾 難波 正志 柏木 仁 佐藤 夕紀 武隈 洋 菅原 満

出版者

一般社団法人 日本薬局学会

雑誌

薬局薬学 (ISSN:18843077)

巻号頁・発行日

vol.13, no.1, pp.68-78, 2021 (Released:2021-04-27)

参考文献数

10

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薬剤師は安全な薬物療法の提供のために,患者から必要な情報を「聞き取る」ことが重要である.しかし,薬局薬剤師の「聞き取り」に対し,一部の一般市民は厳しい視線を投げかけており,患者の理解を促すためのエビデンス構築が急務である.本研究は「患者への聞き取り」に基づき実施された疑義照会に着目し,その実態解明と医療安全への貢献度評価を試みた.解析には北海道大学病院の近隣薬局の疑義照会データを用いた.その結果,聞き取りに基づく疑義照会は「薬学的疑義照会の 33.3%を占め,高い許諾割合(98.5%)を有し,用法や用量などの疑義照会分類において,医療安全への貢献度が高い」ことが見いだされた.また,このうち「医師からの説明と処方内容が食い違う」ことが発端となった事例が,特に医療安全へ貢献していることが示された.「患者への聞き取り」に基づく疑義照会の有用性を広く調査するための基礎となる知見が創出された.

著者

加藤 信太郎 齋藤 佳敬 小野田 紘子 熊井 正貴 今井 俊吾 敦賀 健吉 武隈 洋 菅原 満

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.7, pp.755-760, 2022-07-01 (Released:2022-07-01)

参考文献数

19

被引用文献数

1

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Naldemedine (Nal) is widely used as a therapeutic drug against opioid-induced constipation. However, patients in phase III trials are limited to those with good performance status (PS). Cancer patients may have inferior PS owing to progression of symptoms and adverse events from chemotherapy. Therefore, it is important to survey the efficacy of Nal in patients with poor PS. This study aimed to evaluate Nal efficacy in patients with poor PS. We retrospectively investigated patients from July 2017 to June 2019 and compared Nal efficacy between patients with good and poor PS. The efficacy of Nal was evaluated using changes in the number of spontaneous bowel movements 7 days before and after the introduction of Nal with reference to previous reports. Multivariate analysis was performed to reveal whether poor PS affects Nal efficacy. In total, 141 patients at the Hokkaido University Hospital were analyzed. The effective rate of Nal from day 1 to day 7 of administration was 71.7% and 71.4% in the patients with good and poor PS, respectively, that from day 1 to day 2 of administration was 61.1% and 57.1%, respectively, and that from day 3 to day 7 of administration was 60.2% and 71.4%, respectively, suggesting an absence of significant differences. Furthermore, results of multivariate analysis showed that “best supportive care” and “body weight (55 kg and above)” reduced Nal efficacy. In conclusion, Nal showed similar effectiveness in patients with poor PS as that in those with good PS.

著者

熊井 正貴 加藤 信太郎 小柳 遼 敦賀 健吉 伊藤 陽一 山田 武宏 武隈 洋 菅原 満 川本 泰之 小松 嘉人

出版者

日本緩和医療学会

雑誌

Palliative Care Research (ISSN:18805302)

巻号頁・発行日

vol.17, no.2, pp.51-58, 2022 (Released:2022-04-15)

参考文献数

26

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【目的】緩和ケアに携わる医療提供者のターミナルケア態度の実態とそれに関連する要因を明らかにすることを目的とした.【方法】がん治療医と緩和ケア医を含む緩和ケアに携わる医療提供者を対象にFrommelt Attitude Toward Care Of Dying Scale Form B日本語版(FATCOD B-J)を用いて質問紙調査を実施した.【結果】解析対象は223例であった(回収率42.2%).FATCOD B-J総得点を目的変数とした重回帰分析の結果,偏回帰係数は年代で40代と比較して30代以下が低く(−3.8),業務から得られる満足感を感じているほうが高く(+5.7),緩和ケアへの関心が強いほうが高かった(+6.2).【考察】緩和ケアへの関心と業務から得られる満足感がターミナルケア態度の涵養に重要である可能性がある.

著者

大津 史子 山田 安彦 岩澤 真紀子 後藤 伸之 武隈 洋 冨田 隆志

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.23, no.2, pp.N1-N9, 2021-08-31 (Released:2021-09-25)

著者

齋藤 佳敬 内山 数貴 坂本 達彦 山﨑 浩二郎 久保田 康生 武隈 洋 小松 嘉人 菅原 満

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.141, no.8, pp.1023-1030, 2021-08-01 (Released:2021-08-01)

参考文献数

23

被引用文献数

2

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Denosumab is a fully monoclonal antibody against the receptor activator of nuclear factor kappa-B ligand (RANKL), and prevents skeletal-related events by bone metastasis. Hypocalcemia is the most typical adverse effect of denosumab use. We have developed a management system for the more efficient and safer management of denosumab administration, and evaluated pharmaceutical interventions for the better control of hypocalcemia. All pharmaceutical interventions in the system from April 2016 to March 2020 were retrospectively evaluated. We have also assessed the incidence of hypocalcemia in 158 patients who were administered denosumab for six months or more in the period. A total of 282 pharmaceutical interventions (7.0% of the total administration) were conducted. The most conducted intervention was regarding hypocalcemia, which involved the suspension of the injection and/or the increase of calcium and vitamin D supplement with 65% adoption and 17% temporary treatment suspensions. Other interventions were about hypercalcemia, request of laboratory examination and ordering supplements, dental consultation, and poor renal function. A total of 199 interventions (70.6%) were adopted, with 33 administrations suspended. The frequency of hypocalcemia was 27.8% with just one patient having grade 2 hypocalcemia, suggesting that there were no severe cases. Moreover, hypocalcemia was significantly normalized following pharmaceutical intervention and/or handling by physicians (p=0.02) according to the system. Conversely, the normalization rate in hypercalcemia did not differ according to the countermeasures. In conclusion, pharmaceutical interventions according to our management system benefit safe denosumab treatment, especially in severe hypocalcemia prevention.

著者

武隈 洋 百 賢二

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.141, no.2, pp.163-164, 2021-02-01 (Released:2021-02-01)

著者

武隈 洋 志賀 弘康 山下 恭範 須田 範行 岩井 美和子 岸野 吏志 宮崎 勝巳

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.29, no.1, pp.62-65, 2003-02-10 (Released:2011-03-04)

参考文献数

8

被引用文献数

2 2

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A 0.625% povidone-iodine solution (PVP-I) for eye washing, a pharmaceutical product prepared in our hospital, is used to disinfect the conjunctival sac in eye surgery. Since iodine is unstable, its bactericidal activity is reduced when PVP-I is diluted. Therefore, the stability of a 0.625% PVP-I solution under various preservation conditions was studied. Its stability was evaluated by pH variation, visual inspection and the residual rate of available iodine. The 0.625% PVP-I solution was stored for 5 weeks at room temperature (25°C) and at 4°C under diffused light or in a dark place. The amount of available iodine was determined by the oxidationreduction titration method according to the fourteenth revised edition of the Japanese Pharmacopoeia (JPXIV). No apparent changes were found by pH variation or visual inspection after storage for 5 weeks either at 4°C or 25°C. The residual rates of available iodine after 5 weeks of storage were 91 % at 25°C and 98% at 4°C, thus suggesting that a reduction in available iodine is smaller at 4°C than at 25°C. This finding also suggests that a reduction in available iodine is dependent on temperature.The results of this study indicate that a 0.625% PVP-I solution for eye washing remains stable for 5 weeks if stored at a temperature of less than 4°C.

著者

武隈 洋 岩井 美和子 藤原 俊恵 川岸 亨 熊井 正貴 松浦 麻耶 馬渕 朋美 須田 範行 宮本 剛典 荻野 修 菅原 満 宮崎 勝巳

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.31, no.7, pp.575-584, 2005-07-10

被引用文献数

5 6

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The results of cancer chemotherapy have been improved remarkably by the development of new drugs and combining drugs in treatment. However, cancer chemotherapy protocols are complicated and the adverse effects are more severe than those of other pharmacotherapies. It was therefore felt important to create a database of protocols for the preparation and dispensing of drugs used in cancer chemotherapy. Using Microsoft Access, we have created a database from 320 protocols we have collected so far from 12 clinical departments and developed operating programs for it. The database has enabled us to search for a protocol using keywords-names of drugs, diseases and clinical departments-and most of the operations can be carried out by the click of a mouse. With our database, pharmacists are able to access protocols quickly and check prescriptions of anticancer drugs even if they are unfamiliar with computers, and we consider it to be a useful tool for this purpose.

著者

高橋 夏子 小林 正紀 板垣 史郎 平野 剛 武隈 洋 菅原 満 井関 健

出版者

日本薬学会

雑誌

Yakugaku Zasshi (ISSN:00316903)

巻号頁・発行日

vol.132, no.6, pp.777-783, 2012-06-01

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The most effective drugs based on the type of cancer are chosen for chemotherapy. Tumor cells can be targeted at the DNA, RNA or protein level, and most of the classical anticancer drugs interact with tumor DNA in a time-dependent manner or a concentration-dependent manner. However, it has been unclear to date whether a combination therapy is carried out by using exact classification. Thus it is necessary to reclassify a great number of anticancer drugs. We propose a new classification system based on pharmacological effects of anticancer drugs. Classification of four anticancer drugs (cisplatin, carboplatin, paclitaxel and gemcitabine) was performed by the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The four anticancer drugs were grouped by IC50 values (inhibitory concentration, 50%) in a time-dependent manner and a concentration-dependent manner. The present approach may be combined to enhance the chemosensitivity, improve the dose of cytotoxic drugs and evaluate the effects of novel anticancer drugs.