- 著者
- 萩庭 丈寿 坂井 進一郎 相見 則郎 山中 悦二 新間 信夫
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.93, no.4, pp.448-452, 1973-04-25 (Released:2008-05-30)
- 参考文献数
- 12
- 被引用文献数
- 21 33
In the reinvestigation of the constituents of Uncaria rhynchophylla MIQ. (Japanese name "kagikazura"), the presence of two oxindole alkaloids, corynoxeine and isocorynoxeine, was demonstrated, besides the reported rhynchophylline and isorhynchophylline.3) Furthermore, four indole alkaloids were newly isolated ; hirsutine, hirsuteine, dihydrocorynantheine, and corynantheine. A chemical structural evidence of hirsutine was obtained from its epimerization to dihydrocorynantheine with acetic acid catalysis.
- 著者
- 山中 悦二 君塚 ゆみ子 相見 則郎 坂井 進一郎 萩庭 丈寿
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.103, no.10, pp.1028-1033, 1983-10-25 (Released:2008-05-30)
- 参考文献数
- 8
- 被引用文献数
- 12 27
Quantitative analysis of the tertiary alkaloids in various parts of Uncaria rhynchophylla MIQ. was made by use of high performance liquid chromatography (HPLC). The best result was obtained in the following conditions : column ; Radial Pak C8 and mobile phase ; CH3CN-0.05M AcONH4 buffer (pH 4.0) [90 : 10]. The result revealed that the constitution of the alkaloids varied markedly depending on the botanical parts examined. While oxindole alkaloids (1, 2, 3 and 6) occupy ca. 97% of total alkaloids in hook, small stem and leaf, respectively, content of indole alkaloids (mainly 8 and 10) is almost exclusive (ca. 96%) in the bark of underground part. In the bark of aerial part both oxindole and indole alkaloids were found to be contained in nearly equal amounts. The alkaloidal content is very low in the wood (aerial or underground part) but the content ratios of rare alkaloids (4 and 7) to the total alkaloids are higher than the other parts.
- 著者
- 萩庭丈寿 坂井 進一郎 相見 則郎 山中 悦二 新間 信夫
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 薬学雑誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.93, no.4, pp.448-452, 1973-04
- 被引用文献数
- 2
In the reinvestigation of the constituents of Uncaria rhynchophylla MIQ. (Japanese name "kagikazura"), the presence of two oxindole alkaloids, corynoxeine and isocorynoxeine, was demonstrated, besides the reported rhynchophylline and isorhynchophylline.^<3)> Furthermore, four indole alkaloids were newly isolated ; hirsutine, hirsuteine, dihydrocorynantheine, and corynantheine. A chemical structural evidence of hirsutine was obtained from its epimerization to dihydrocorynantheine with acetic acid catalysis.