著者

西川 剛 大内 誠

出版者

公益社団法人 有機合成化学協会

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.81, no.4, pp.313-323, 2023-04-01 (Released:2023-04-08)

参考文献数

59

---

In chain-growth polymerization, (co)polymerization abilities of monomers are heavily dependent on the element or functional group attaching to vinyl moiety, resulting in the limitation of accessible polymers. The replacement of the element on the polymer main chain could lead to access new class of polymers with overcoming the synthetic limitations. Herein, we describe the usability of alkenylboronic acid derivatives as the monomers for radical polymerization and post-polymerization transformation through carbon-boron bond-cleaving side-chain replacement. The key for radical polymerization ability of alkenyl boronate was vacant p-orbital of boron for moderate stabilization of chain growth radical. The alkenyl boronate monomers are usable for copolymerization with common monomers as well as for RAFT polymerization. The C-B bond transformation allows syntheses of conventionally inaccessible polymers, such as poly(α-methyl vinyl alcohol), poly(α-methyl vinyl amine), styrene-vinyl alcohol copolymer, and ethylene-acrylate copolymer. Boron on the polymer main chain was also used as the trigger for stimuli-responsive backbone degradation of methacrylate polymer through C-B bond homolysis and β-scission. Thus, alkenyl boronate monomers have an impact on not only breakthrough of the limitation in polymer synthesis but also development of novel polymer functions.

著者

西川 剛史 冨樫 弘一 木田 直也 今枝 加奈子 高島 英隆

出版者

一般社団法人 日本消化器内視鏡学会

雑誌

日本消化器内視鏡学会雑誌 (ISSN:03871207)

巻号頁・発行日

vol.54, no.10, pp.3433-3439, 2012 (Released:2012-10-31)

参考文献数

10

---

症例は60歳台,男性.多発性骨髄腫にて加療中.発熱,腹痛にて受診,腹部CTにてS状結腸憩室穿孔による腹腔内膿瘍と診断した.経皮的ドレナージが奏功するも腹痛は持続,人工肛門の適応と考えたが,全身状態から手術は困難であった.そこで,経皮的内視鏡的盲腸瘻造設術施行後,バルーン拡張を加え,瘻孔にシリコン性開創器を挿入し人工肛門の代替機能を有する盲腸瘻を作製した.一連の手技にて大きな合併症は認めず,一定の効果を得ることができた.