著者

赤真 清人 亀山 昭一 大谷 昌 貞弘 省二 村田 良介

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Medical Science and Biology (ISSN:00215112)

巻号頁・発行日

vol.24, no.3, pp.183-187, 1971 (Released:2010-03-19)

参考文献数

10

被引用文献数

6 13

著者

岩佐 三郎 石田 説而 赤真 清人

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Medical Science and Biology (ISSN:00215112)

巻号頁・発行日

vol.38, no.2, pp.53-65, 1985 (Released:2010-03-19)

参考文献数

35

被引用文献数

3 3

---

Intracerebral injection of vaccine into the mouse induced swelling of the brain. The swelling reached the maximum in the intensity by day 1 and persisted for several days. A method for quantitative determination of the brain-swelling activity of the vaccine was developed. A positive regression coefficient was found only between the brain-swelling and the lymphocytosis-promoting activities. Such activity was no longer shown with the vaccine heat-treated for 30 min at 80 C, but it was restored upon addition of the lymphocytosis-promoting factor (LPF) that caused no brain swelling by itself. The activity, therefore, was ascribed to cooperation of LPF and a certain heat-stable component other than endotoxin contained by pertussis vaccine.