- 著者
- 落合 英二 岡本 敏彦 菅沢 勉 谷 英郎 坂井 進一郎 洪 山海 遠藤 英也
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Pharmaceutical Bulletin (ISSN:03699471)
- 巻号頁・発行日
- vol.1, no.1, pp.60-65, 1953-03-20 (Released:2008-02-26)
- 被引用文献数
- 2 5
- 著者
- 遠藤 英也 久米 文弘
- 出版者
- The Japanese Cancer Association
- 雑誌
- GANN Japanese Journal of Cancer Research (ISSN:0016450X)
- 巻号頁・発行日
- vol.54, no.4, pp.443-453, 1963-12-31 (Released:2008-10-23)
- 参考文献数
- 23
- 被引用文献数
- 2
From the fact that 4-hydroxyaminoquinoline 1-oxide (4-HAQO) as well as 4-nitroquinoline 1-oxide (4-NQO) have λ-phage inducing ability in lysogenic Escherichia coli K12 and from the studies of Okabayashi, showing that not only 4-NQO but also 4-HAQO are mutagenic and able to produce the phenotypically same mutants in Aspergillus niger, similarity between these two substances in their biological actions was examined on (1) carcinogenicity, (2) growth-inhibiting action, and (3) intranuclear inclusion-forming action.1) 4-HAQO•HCl in peanut oil and cholesterol mixture was injected into the subcutaneous tissue of rats. Subcutaneous tumors were induced in 8 of the 15 effective rats (53%) in the first group and in 16 of 17 rats (94%) in the second group.2) Three groups, consisting of 10 mice each, were inoculated with Ehrlich ascites tumor cells intraperitoneally. Twenty-four hours after the inoculation, the first group was treated daily with 0.5mg/kg body weight of 4-HAQO•HCl dissolved in physiological saline containing 0.4% carboxymethylcellulose, the second group with 7mg of 4-NQO, and the third with solvent alone. The treatment was continued for 10 days. All the mice of the first group and all but 2 mice of the second survived over 50 days, whereas the third (control) group survived only 15 days.3) When the Chang's liver cells were incubated for 24 hours at 37° in a culture media containing 4-HAQO•HCl in the final concentration of 7×10-5M, intranuclear inclusions phenotypically identical with those induced by 4-NQO were produced in about 60% of all the cells.These results were discussed in relation to the carcinogenic mechanism of 4-NQO.
- 著者
- 小嶋 正治 栗原 悟 金沢 洋子 原田平 輝志 前原 喜彦 遠藤 英也
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.36, no.3, pp.1194-1197, 1988-03-25 (Released:2008-03-31)
- 参考文献数
- 16
- 被引用文献数
- 8 11
The metabolic products of 2-deoxy-2-fluoro-D-glucose (FDG) and 2-deoxy-2-fluoro-D-mannose (FDM) in sarcoma 180 cells transplanted in mice were investigated by fluorin-19 nuclear magnetic resonance (19F-NMR) spectroscopy. It became apparent that the administered FDG was converted to FDM (and/or FDM-6-phosphate) in tumor cells, and also the administered FDM was converted to FDG (and/or FDG-6-phosphate). At 9h after administration of FDM, the ratio of FDG (and/or FDG-6-phosphate) and FDM (and/or FDM-6-phosphate) reached equilibrium. On the other hand, it took more than 48h in the case of FDG administration. The equilibrium amount of FDM (and/or FDM-6-phosphate) was approximately four times as much as that of FDG (and/or FDG-6-phosphate) in both cases.