著者

金谷 浩一郎 今手 祐二 竹本 剛 蓮池 耕二 綿貫 浩一 守谷 啓司

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.95, no.2, pp.203-209, 2002-02-01 (Released:2011-11-04)

参考文献数

28

被引用文献数

1 2

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PURPOSE: Tsumura Co.'s Bakumondo-to (TJ-29) is a Chinese herb medicine prescribed widely in Japan for bronchitis and laryngitis. It is well known that TJ-29 not only has a variety of effects including anti-inflammatory and antitussive properties, but also is capable of increasing salivary secretions. The purpose of this study is to examine whether TJ-29 can reduce mucosal toxicity caused by radiotherapy in patients with early laryngeal carcinoma.METHODS AND MATERIALS: Between 1993 and 1999, 20 patients with primary early laryngeal carcinoma were treated by radiotherapy at Nagato General Hospital. All patients were treated with 2 Gy per fraction daily, 5 days a week. Eight patients formed the control group (no TJ-29) and 12 patients received TJ-29 throughout the radiation therapy. The severity of daily subjective symptoms such as hoarseness, xerostomia or pharyngoxerosis, cough, and sore throat were graded O to 3 according to descriptions on the clinical charts.RESULTS: No statistically significant between-group differences were seen in subjective hoarseness, xerostomia or pharyngoxerosis, and cough. However the mean final grade of subjective sore throat was less severe in the TJ-29 group (p=0.023).CONCLUSION: Despite the limited number of patients, this study suggests that TJ-29 was able to reduce the severity of mucositis induced by radiotherapy. Further intensive research is needed.

著者

池田 卓生 関谷 透 木戸 利成 金谷 浩一郎 田原 哲也 原 浩貴

出版者

The Oto-Rhino-Laryngological Society of Japan, Inc.

雑誌

日本耳鼻咽喉科学会会報 (ISSN:00306622)

巻号頁・発行日

vol.97, no.4, pp.703-708, 1994 (Released:2008-03-19)

参考文献数

7

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今回我々は,北海道上砂川町にある地下無重力実験センター(Japan Microgravity Center: JAMIC)を利用する機会を得たので,これが身体平衡系の研究における新しい実験手段として有用であるかを検討する目的で,平衡系実験セット(姿勢•行動観察用及び筋電図記録用)を作製し,カエルを用いた予備実験を行った.1) 姿勢•行動観察では,無処置群において頭部が背屈し,四肢が伸展するという特徴的な姿勢が観察できた.また前庭神経切断群では,落下前の姿勢変化はそのまま持続し,障害側を下にする回転運動が見られた.2) 筋電図では,落下直後に前庭脊髄反射のためと考えられる筋活動の亢進を認めた.また前庭神経切断例では,術側の潜時が,やや遅延した.3) カエルは,落下実験施設を利用した平衡系実験の実験動物として適当である.4) 微小重力暴露時の身体平衡系の研究において,落下実験施設は非常に有用な実験手段である.