- 著者
 
          - 
             
             中田 智子
             
             高田 勝美
             
             小森 万希子
             
             鈴木 英弘
             
             菅原 基晃
             
          
 
          
          
          - 出版者
 
          - 特定非営利活動法人 日本バイオレオロジー学会
 
          
          
          - 雑誌
 
          - 日本バイオレオロジー学会誌 (ISSN:09134778)
 
          
          
          - 巻号頁・発行日
 
          - vol.11, no.3, pp.27-33, 1997-09-30 (Released:2012-09-24)
 
          
          
          - 参考文献数
 
          - 35
 
          
          
        
        
        
        Using the rabbit ear chamber (REC) method, the author compared the effect of hypocapnia and that of normocapnia on cutaneous microcirculation of rabbits. Eight rabbits, weighting 3-4kg, were used for this study, which were anesthetized with pentobarbital and pancuronium. To maintain PaO2 at 100-150mmHg and PaCO2 at 20-25mmHg (HYPOCAPNIC GROUP), they were mechanically ventilated with air-O2 and regulated. After observing the circulation of arteriole during hypocapnia for 15-20 minutes, to induce normocapnia, 100% CO2 was added to the inspired gas stepwise until PaCO2 reached 35-45mmHg (NORMOCAPNIC GROUP). And the circulationof arteriole was observed during normocapnia for 15-20 minutes.No significant changes were observed in the blood pressure, heart rate and pulse pressure. However, significant change was observed in pH. During hypocapnia, the diameter, blood-flow velocity and blood-flow rate of the arterioles were markedly reduced (p<0.05).This study using REC has shown that hypocapnia causes cutaneous microcirculatory changes and increase systemic vascular resistance.