著者
中田 智子 高田 勝美 小森 万希子 鈴木 英弘 菅原 基晃
出版者
特定非営利活動法人 日本バイオレオロジー学会
雑誌
日本バイオレオロジー学会誌 (ISSN:09134778)
巻号頁・発行日
vol.11, no.3, pp.27-33, 1997-09-30 (Released:2012-09-24)
参考文献数
35

Using the rabbit ear chamber (REC) method, the author compared the effect of hypocapnia and that of normocapnia on cutaneous microcirculation of rabbits. Eight rabbits, weighting 3-4kg, were used for this study, which were anesthetized with pentobarbital and pancuronium. To maintain PaO2 at 100-150mmHg and PaCO2 at 20-25mmHg (HYPOCAPNIC GROUP), they were mechanically ventilated with air-O2 and regulated. After observing the circulation of arteriole during hypocapnia for 15-20 minutes, to induce normocapnia, 100% CO2 was added to the inspired gas stepwise until PaCO2 reached 35-45mmHg (NORMOCAPNIC GROUP). And the circulationof arteriole was observed during normocapnia for 15-20 minutes.No significant changes were observed in the blood pressure, heart rate and pulse pressure. However, significant change was observed in pH. During hypocapnia, the diameter, blood-flow velocity and blood-flow rate of the arterioles were markedly reduced (p<0.05).This study using REC has shown that hypocapnia causes cutaneous microcirculatory changes and increase systemic vascular resistance.
著者
小森 万希子 高田 勝美 中田 智子 塩谷 雅子 田口 晶子 鈴木 英弘 菅原 基晃
出版者
東京女子医科大学学会
雑誌
東京女子医科大学雑誌 (ISSN:00409022)
巻号頁・発行日
vol.64, no.2, pp.180-180, 1994-02-25

東京女子医科大学学会第297回例会 平成6年2月17日 東京女子医科大学 弥生記念講堂