- 著者
- 味澤 幸義 赤羽 健司 赤羽 増夫 佐藤 和明 玉井 哲郎 斉藤 勝 田中 信之 鎌田 晃爾 小林 通洋
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 藥學雜誌 = Journal of the Pharmaceutical Society of Japan (ISSN:00316903)
- 巻号頁・発行日
- vol.116, no.9, pp.735-747, 1996-09-25
- 参考文献数
- 13
A number of benzimidazole derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inhibitory activities were found in the compounds having carboxyl or tetrazolyl group. As the most preferred compound, 4-(5,6-dichlorobenzimidazol-2-yl)-N-(3-methoxypropyl)-N-pentylglutaramic acid (4g) was selected.
- 著者
- 味澤 幸義 赤羽 健司 赤羽 増夫 佐藤 和明 玉井 哲郎 斉藤 勝 田中 信之 鎌田 晃爾 小林 通洋
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.116, no.9, pp.735-747, 1996-09-25 (Released:2008-05-30)
- 参考文献数
- 13
- 被引用文献数
- 1 1
A number of benzimidazole derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inhibitory activities were found in the compounds having carboxyl or tetrazolyl group. As the most preferred compound, 4-(5, 6-dichlorobenzimidazol-2-yl)-N-(3-methoxypropyl)-N-pentylglutaramic acid (4g) was selected.