著者

鏑木 豊

出版者

The Kitakanto Medical Society

雑誌

北関東医学 (ISSN:00231908)

巻号頁・発行日

vol.35, no.2, pp.143-152, 1985-04-10 (Released:2009-10-15)

参考文献数

30

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In order to investigate the metabolism and mechanism of action of testosterone in the central nervous system, the following experiments were performed : 1. The pathway of testosterone metabolism in the anterior pituitary and the hypothalamus of male Wistar rats was analyzed using GC-MS. Main metabolites were identified as androst-4-ene-3, 17-dione, 5α-androstan-17β-ol-3-one, 5α-androstane-3α, 17β-diol, 5α-androstane-3β, 17β-diol, androst-4-ene-3α, 17β-diol and androst-4-ene-3β, 17β-diol.2. The metabolism of androst-4-ene-diol into 5α-androstanediol in the CNS was then analyzed using androst-4-ene-3α, 17β-diol-3-D1 (D = deuterium) and androst-4-ene-3β, 17β-diol-3-D1 as the incubation substrate. Twenty to thirty percent of androst-4-ene-3α, 17β-diol was converted directly into 5α-androstane-3α, 17β-diol, but androst-4-ene-3β, 17β-diol was not converted into 5α-androstane-3β, 17β-diol.3. Change in 5α-reductase activity in the CNS after castration was analyzed by measuring the amount of 5α-reduced metabolites (5α-DHT & 5α-androstanediol) formed by the incubation of testosterone-14C with a homogenate of the CNS tissues.It was evident that the 5α-reductase activity of the pituitary increased 5-fold at 5 weeks after castration, but in the hypothalamus no significant change was recognized.

著者

鏑木 豊 田辺 俊成 義澤 雄介 飯泉 陽子 北村 啓次郎

出版者

Meeting of Osaka Dermatological Association

雑誌

皮膚 (ISSN:00181390)

巻号頁・発行日

vol.40, no.3, pp.292-295, 1998 (Released:2010-08-25)

参考文献数

9

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42歳男性。南会津の山中を歩いた10日後より, 38℃ 台の発熱, 右鼠径リンパ節腫大と全身に多発散在する小紅斑が出現した。近医にてセファロスポリン系の抗生剤が投与されたが症状が改善しないため当科を受診した。皮疹は自覚症なく小豆大ないし爪甲大の紅斑で浸潤を触れない。右下腿に刺し口が見られた。ツツガムシ病を疑い検査を進めたところ, 免疫ペルオキシダーゼ法でKarp型リケッチア感染と診断された。ミノサイクリン経口投与により治癒せしめた。