著者

畑中 知笑美 間瀬 広樹

出版者

日本緩和医療学会

雑誌

Palliative Care Research (ISSN:18805302)

巻号頁・発行日

vol.9, no.1, pp.501-504, 2014 (Released:2014-02-17)

参考文献数

9

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【緒言】オキサリプラチンは, 結腸・直腸がんに対して有効な白金系抗がん剤である. しかしながら, 半数近くの患者に急性および蓄積性の末梢神経障害が生じ, 日常生活に及ぼす影響は甚大である. 末梢神経障害への対処は重要であるにもかかわらず, いまだ確立された方法はない. 【症例】60歳代, 女性. 再発大腸がんに対してSOX療法が施行されたが, 治療当初より末梢神経障害が発現した. ピリドキサールリン酸エステル水和物や牛車腎気丸を継続服用したが無効であったため, 患部へ1.35% l-メントール含有軟膏を1日3回, 1回につきおおむね0.5~1 gを両足裏に塗布するよう, 薬局で服薬指導した. 塗布開始当日より症状のすみやかな消失が認められ, その後SOX療法終了までの1カ月間塗布を継続したが症状の再発はみられなかった. 【結論】1.35% l-メントール含有軟膏の塗布は, オキサリプラチン誘導末梢神経障害の改善に効果的である可能性が示唆された.

著者

早川 裕二 溝神 文博 長谷川 章 天白 宗和 間瀬 広樹 小林 智晴

出版者

一般社団法人 日本老年薬学会

雑誌

日本老年薬学会雑誌 (ISSN:24334065)

巻号頁・発行日

vol.5, no.1, pp.1-6, 2022 (Released:2022-04-21)

参考文献数

17

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Polypharmacy involves problems related to not only the use of many medications but also improper drug administration. The questionnaires used at the time of admission were retrospectively investigated to determine the number of drugs that patients would like to reduce. Most patients wanted to reduce the number of drugs prescribed to them. The target patients were those who visited the National Center for Geriatrics and Gerontology and met the criteria during the hospitalization period from August 1, 2020 to November 30, 2020. In all, we selected 313 patients: 68 in the drug reduction group and 245 in the non-drug reduction group. We investigated the extent of desired reduction and the patient background factors for both groups. Multivariate analysis revealed significant differences between the groups in family management with an adjusted odds ratio of 2.62 (95% CI 1.30-5.29, P < 0.01) and in the number of drugs with an adjusted odds ratio of 1.20 (95% CI 1.09-1.31, P < 0.01). Analysis of the area under the receiver operating characteristic curve(AUC)was carried out for all the cases. The cutoff for self-management was six points (AUC = 0.73, 95% CI 0.64-0.81, P < 0.01). Patients on polypharmacy who are taking more than six drugs, especially family-managed patients, often wish to reduce the number of medications and prescribe it from a pharmaceutical point of view. This aspect needs to be reviewed further.

著者

杉本 智哉 近藤 有 一木 万奈美 荒川 裕貴 間瀬 広樹 牛膓 沙織 佐久間 昌基 小山 佐知子 大島 有美子 宮崎 雅之 築山 郁人 佐藤 由美子 久田 達也 板倉 由縁 山田 清文

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.44, no.9, pp.441-448, 2018-09-10 (Released:2019-09-10)

参考文献数

26

被引用文献数

1

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The objective of this study was to evaluate the cost-effectiveness of pegfilgrastim (Peg-G) and daily filgrastim (Fil-G) for the primary prophylaxis against febrile neutropenia (FN) in patients with non-Hodgkin lymphoma (NHL) who received cyclophosphamide, vincristine, doxorubicin and prednisolone (CHOP) therapy. We developed a decision analytical model reflecting the clinical processes of NHL patients who received first CHOP therapy. The probabilities at each clinical endpoint were obtained from published sources. To estimate the costs and duration of FN treatment, we analyzed the medical records of NHL patients in hospitals participating in this study. The costs of Peg-G and Fil-G were calculated according to the National Health Insurance drug price list. We assessed an incremental cost-effectiveness ratio (ICER) for a single dose of Peg-G versus 11-days of Fil-G from the perspective of health insurance payers. The sensitivity and robustness of this model were validated by the tornado-diagram and Monte Carlo Method. The costs associated with primary prophylaxis with a single dose of Peg-G and 11-days of Fil-G were 109,628 JPY and 109,243 JPY, respectively. The quality adjusted life years (QALYs) associated with the two strategies were 0.0339 QALYs and 0.0337 QALYs, respectively. The ICER for the Peg-G versus Fil-G was 2,788,571 JPY per QALY. The tornado-diagram revealed that the main influential factors included the cost of Peg-G, number of Fil-G doses, and cost of Fil-G. Monte Carlo simulation revealed an 18.3% probability that Peg-G was cost-effective compared with Fil-G. A single dose of Peg-G was cost-effective compared with 11-days of Fil-G.

著者

坂野 昌志 間瀬 広樹 島田 泉 伊藤 由紀 中村 卓巨 青田 真理子 中村 桂 近藤 祥子 堀端 志保 中野 良美 五家 邦子 鈴木 末廣 井端 英憲

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.33, no.11, pp.920-924, 2007 (Released:2009-09-04)

参考文献数

12

被引用文献数

2 2

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In the treatment of cancer,radiotherapy is equally important to chemotherapy,and the pain arising from the adverse reactions of esophagitis and stomatis is treated with sodium aliginate (AL-Na).We decided to try cooling AL-Na because it was felt that doing this would enhance the analgesic effect.When cooled,the time of adhesion to the affected part was longer than that for AL-Na at room temperature and the pain relieving effect was greatly enhanced.