著者

佐藤 敬 高松 滋 作田 茂 水野 成徳 高松 むつ 武田 俊平

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.13, no.3, pp.410-413, 1982-09-01 (Released:2010-08-05)

参考文献数

3

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The effects of mefenamic acid on in vitro platelet functions, namely thrombininduced production of thiobarbituric acid-reactive substances (TBARS) and ADP-induced platelet aggregation, were investigated and compared with those of aspirin and flurbiprofen.Mefenamic acid inhibited platelet TBARS production almost comparatively to aspirin and flurbiprofen. The inhibitory effects of these three drugs on platelets from patients with atherosclerotic vascular diseases were smaller than the effects on platelet from normal subjects. Percent inhibition, by mefenamic acid, on platelet TBARS production correlated positively with maximal aggregation in these subjects.Mefenamic acid also strongly suppressed platelet aggregation. In contrast to aspirin and flurbiprofen, of which effects were limited solely on secondary aggregation, mefenamic acid abolished primary aggergation, as well. Therefore, besides being a strong inhibitor of platelet thromboxane generation, mefenamic acid may exert its anti-platelet action through unknown mechanism (s). Antiplatelet action of this drug can be also characterized by the result suggesting that the inhibition tends to be large on platelets with higher aggregatory activity.

著者

佐藤 敬 高松 滋 逸見 一穂 作田 茂 水野 成徳 目時 弘文 高松 むつ

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.7, no.2, pp.271-277, 1979-07-01 (Released:2011-09-21)

参考文献数

12

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The HDL-cholesterol (HDL-Ch) concentration of 153 cerebrocascular patients within 1 year from onset and 257 controls were determined in the supernatant of serum in heparin-Ca++ precipitation method. In some patients, serum HDL-phospholipid (HDL-PL) concentrations were also determined. Liver function tests (GOT, GPT, TTT, ZST) were normal in all of these subjects, and control subjects had no adnormalities in physical findings, blood pressure, ECG, urinalysis etc.The average values in male and female controls were 65±20.9mg/dl and 65±22.3mg/dl, respectively. The value of female subjects over 55 years of age was lower than those of age-matched male and female under 54. There was no significant change by age in values of male control. In male patients with cerebral infarction, average HDL-Ch value was 55±18.6mg/dl and it was significantly lower than the control value. The value of female patients was 62±15.0mg/dl. In female, there was no significant difference between patients and control. Among the patients with cerebral infarction, the cases with angiographically demonstrated obstruction of internal carotid or middle cerebral arteries showed lower value as compared to those without such findings. In male and female patients with cerebral hemorrhage, average HDL-Ch concentrations were 55±13.3mg/dl and 60±16.8mg/dl respectively. Again only the value of male patients was significantly lower than that of control.Considering the importance of balance between atherogenic and anti-atherogenic properties of cholesterol in various lipoprotein fractions, HDL-cholesterol/total cholesterol (HDL-Ch/TC) ratio was calculated in each subjects. The average values of this ratio in healthy men and women were 0.37±0.13 and 0.37±0.14, respectively. The value of male patients with cerebral infarction was 0.30±0.10, it was significantly lower than the control value. The values of female patients with cerebral infarction, male and female patients with cerebral hemorrhage were 0.33±0.09, 0.35±0.10 and 0.35±0.11, respectively. These values exhibited no significant difference when compared with each controls. From these results, it was recognized that at a given concentration of serum total cholesterol, male patients with cerebral infarction had relatively less cholesterol in their HDL fraction as compared to healthy subjects.Serum HDL-PL concentrations in male patients either with cerebral infarction or cerebral hemorrhage, were significantly lower than the control value. The difference between female patients and control was insignificant.These results may suggest the importance of HDL-Ch for the development of cerebral atherosclerosis and subsequent cerebral infarction at least in man.