著者

駒田 富佐夫 中山 優子 高良 恒史

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.20, no.2, pp.72-80, 2018-08-31 (Released:2018-09-12)

参考文献数

18

被引用文献数

1

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Objectives: The aim of this study was to investigate both the time‐to‐onset and the onset‐pattern of drug‐induced blood disorders (DIBD) following the administration of monoclonal antibody agents through the use of the spontaneous adverse reaction reporting system of the Japanese Adverse Drug Event Report (JADER) database. Methods: Data in the JADER database from April 2004 to October 2017 were downloaded from the Pharmaceuticals and Medical Devices Agency website. The DIBD dataset for monoclonal antibody agents was constructed based on the data for the drug information and adverse drug reactions. The information for the adverse drug reactions was categorized in accordance with the preferred terms of the Medical Dictionary for Regulatory Activities and included thrombocytopenia, platelet count decreased, neutropenia, neutrophil count decreased, leukopenia, white blood cell count decreased, pancytopenia, anaemia, agranulocytosis, granulocyte count decreased, granulocytopenia, and bone marrow failure. This dataset was then used to calculate the median onset times for the DIBD and the Weibull distribution parameters. Results: The median onset times of the DIBD for gemtuzumab ozogamicin, cetuximab, ramucirumab, trastuzumab, panitumumab, bevacizumab, infliximab, rituximab, trastuzumab, and ibritumomab tiuxetan (90Y) were 4, 10, 13, 14, 14, 14, 16, 16, 27, and 28 days, respectively. The Weibull distributions for cetuximab, trastuzumab, bevacizumab, infliximab, and tocilizumab were estimated to fit the early failure type profile, while those for gemtuzumab ozogamicin, ramucirumab, rituximab, and ibritumomab tiuxetan (90Y) were estimated to fit the wear out failure type profile. The Weibull distributions for panitumumab were estimated to fit the random failure type profile. Conclusions: The results of the present study clarified both the most likely time period and the onset‐pattern of DIBD that can occur in patients after the administration of monoclonal antibody agents.

著者

高良 恒史 大西 憲明 堀部 紗世 橋詰 勉 金澤 治男 横山 照由

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.29, no.1, pp.77-82, 2003-02-10 (Released:2011-03-04)

参考文献数

12

被引用文献数

3 3

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For the development of a practical training system to effectively teach sterilization techniques, we conducted on unregistered questionnaire survey of the undergraduate student's view about the training practice for glass ample cutting, and then evaluated and discussed the introduction to practical training of pharmaceutical health care and sciences for the third-grade undergraduate students. Among 96 third-grade undergraduate students, 54 students (56%) had some experience in cutting glass amples while the remaining students did not. Twenty-six of the 54 students with some experience (48%) had some anxiety regarding glass ample cutting, while only 13 of the 42 inexperienced students (31 %) had such anxiety. Twelve of the 13 inexperienced students overcame some anxiety against glass ample cutting. Moreover, 87 of 96 students (91%) considered that receiving practice in glass ample cutting was necessary for them. Consequently, the training programs on glass ample cutting were found to be appropriate and useful for students to develop sufficient practical skills and accurate ability in sterilization techniques. As a result, we are now preparing to introduce a training program for glass ample cutting in addition to the regular practical training of pharmaceutical health care and sciences at Kyoto Pharmaceutical University.

著者

高良 恒史 大西 憲明 橋詰 勉 金澤 治男 横山 照由

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.1, pp.57-62, 2002-02-10 (Released:2011-03-04)

参考文献数

8

被引用文献数

5 5

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In 1996, the Department of Clinical Pharmacy at the Education and Research Center of Kyoto Pharmaceutical University was established to enrich the education program of pharmaceutical health care and sciences, and to also be used as a pre-training program for undergraduates before taking part in externships at hospitals or pharmacies. In the following year, the training center of clinical pharmacy (a simulated pharmacy) was also founded, and has since been used for the practical training of pharmaceutical health care and sciences for third-year undergraduate students. We herein describe our findings of an unregistered questionnaire survey of the undergraduate students' view, while also evaluating and discussing the effectiveness of this training program.Almost all students considered undergoing the practical training to be useful and necessary for them, because their scores before and after the training were 4.24 and 4.56 points on a scale of 5 point maximum, respectively. The students also evaluated each part of the training program, with mean values before and after the practice 3.75-4.01 and 3.70-4.39, respectively. The students did voice various opinions regarding the practical training program. Consequently, the students are satisfied with the practical training programs at present, however, we will have to continually improve such programs to better meet the students needs.

著者

高良 恒史 大西 憲明 堀部 紗世 橋詰 勉 金澤 治男 横山 照由

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.29, no.1, pp.77-82, 2003

参考文献数

12

被引用文献数

5 3

---

For the development of a practical training system to effectively teach sterilization techniques, we conducted on unregistered questionnaire survey of the undergraduate student's view about the training practice for glass ample cutting, and then evaluated and discussed the introduction to practical training of pharmaceutical health care and sciences for the third-grade undergraduate students. Among 96 third-grade undergraduate students, 54 students (56%) had some experience in cutting glass amples while the remaining students did not. Twenty-six of the 54 students with some experience (48%) had some anxiety regarding glass ample cutting, while only 13 of the 42 inexperienced students (31%) had such anxiety. Twelve of the 13 inexperienced students overcame some anxiety against glass ample cutting. Moreover, 87 of 96 students (91%) considered that receiving practice in glass ample cutting was necessary for them. Consequently, the training programs on glass ample cutting were found to be appropriate and useful for students to develop sufficient practical skills and accurate ability in sterilization techniques. As a result, we are now preparing to introduce a training program for glass ample cutting in addition to the regular practical training of pharmaceutical health care and sciences at Kyoto Pharmaceutical University.