著者

奥村 学 瀬尾 量 長沼 広子 日高 慎二 児玉 裕文 前田 共秀 橋本 強 鶴岡 道雄

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.17, no.3, pp.162-166, 1991-06-20 (Released:2011-08-11)

参考文献数

4

---

A new computerized system for making of drug envelope has been developed in Miyazaki Medical College Hospital Department of Pharmacy.Although such system has been already developed, most of system were not sufficient for labor-saving.This developed system has no need to put label on drug envelope, and to separate drug envelope.And the time to produce prescription and drug envelope was half as much as that of writing by hand.Hence We can use free time that we got by our system for other work.At all points, our system make a great contribution to labor-saving at hospital pharmacy.

著者

瀬尾 量 鶴岡 道雄 橋本 強 藤永 稔夫 小田切 優樹 上釜 兼人

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.31, no.1, pp.286-291, 1983-01-25 (Released:2008-03-31)

参考文献数

15

被引用文献数

48 62

---

Inclusion complex formations of spironolactone (SP) with three cyclodextrins (α-, β-, γ-CyDs) in aqueous solution and in the solid state were studied by the solubility method, by spectroscopic methods (UV, CD, IR) and by X-ray diffractometry, and their modes of interaction were assessed. The solid complexes of SP with β- and γ-CyDs were obtained in molar ratios of 1 : 2 and 2 : 3, respectively, and their dissolution, membrane permeation and oral absorption properties were examined. The rates of dissolution and permeation through a cellophane membrane in water were significantly increased by inclusion complexation (γ-CyD complex>β-CyD complex>SP alone), depending upon the solubility of the test samples. The serum levels of SP following oral administration of CyD complexes were found to be greater than those after administration of SP alone. The results indicated that the γ-CyD complex rather than β-CyD complex may have great utility as a faster dissolving form of SP able to produce higher serum levels.