著者

奥村 学 瀬尾 量 長沼 広子 日高 慎二 児玉 裕文 前田 共秀 橋本 強 鶴岡 道雄

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.17, no.3, pp.162-166, 1991-06-20 (Released:2011-08-11)

参考文献数

4

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A new computerized system for making of drug envelope has been developed in Miyazaki Medical College Hospital Department of Pharmacy.Although such system has been already developed, most of system were not sufficient for labor-saving.This developed system has no need to put label on drug envelope, and to separate drug envelope.And the time to produce prescription and drug envelope was half as much as that of writing by hand.Hence We can use free time that we got by our system for other work.At all points, our system make a great contribution to labor-saving at hospital pharmacy.

著者

荻窪 哲也 日高 宗明 奥村 学 藤田 健一 山崎 啓之 浅生 将英 岩切 智美 佐々木 裕美 児玉 裕文 有森 和彦

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.32, no.5, pp.392-399, 2006-05-10

被引用文献数

2 2

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In view of the lack of information on the extent to which tea beverages inhibit the activity of human cytochrome P 450 3A (CYP 3A), we investigated their effect on the midazolam 1' -hydroxylation activity of CYP 3A contained in human liver microsomes. "Grapefruit (white)" was used as a positive control, and "Valencia Orange", as a negative control. All the tea beverages tested significantly inhibited the midazolam 1' -hydroxylation activity of CYP 3A in a concentration-dependent manner and inhibition was particularly marked for Katekin 600^[○!R] and Banso-reicha^[○!R] (5.0%, v/v). The potency of the inhibitory effects was similar to that of grapefruit. The inhibitory effects on the activity of CYP 3A were enhanced by preincubation of tea samples (2.5%, v/v) with microsomal fractions for 5 to 30min in a preincubation period-dependent manner. These results suggest that Katekin 600^[○!R] and Banso-reicha^[○!R] contain mechanism-based inhibiting agents. Further, the inhibitory effects on CYP 3A of green tea beverages seemed to be enhanced by catechins with the enhancement depending on the catechin concentration indicated on the label. In conclusion, we found that there were ingredients that inhibited CYP 3A activity in all of the tea beverages, and they were probably catechins.