著者

AKIKO KATO TETSUJI SAEKI SEIKICHI SUZUKI KUNIO ANDO GAKUZO TAMURA KEI ARIMA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.22, no.7, pp.322-326, 1969-07-25 (Released:2006-04-12)

参考文献数

4

被引用文献数

16 19

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A new antibiotic, oryzachlorin, C26H31O8N2S2Cl(λmax 298mμ in ethanol) has been isolated from Aspergillus oryzae. It strongly inhibits the growth of many yeasts but has no effect on bacteria or filamentous fungi. It also has antiviral activity in vitro.

著者

Satoshi TAKASHIMA Naohito NISHII Akiko KATO Tatsuya MATSUBARA Sanae SHIBATA Hitoshi KITAGAWA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0233, (Released:2015-08-08)

被引用文献数

1 9

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Resistin, one of the adipokines that has a cycteine-rich C-terminus, is considered to relate to the development of insulin resistance in rats. However, in cats, there is little knowledge regarding resistin. In this study, we cloned the feline resistin cDNA from adipose tissue by RT-PCR. The feline resistin clone contained an entire open reading frame encoding 107 amino acids that had 72.8%, 75.4%, 50.9% and 51.8% homology with bovine, human, mouse, and rat homologues, respectively. In both subcutaneous and visceral adipose tissues, the transcription levels of feline resistin mRNA were significantly higher in obese cats than normal cats, and those of feline adiponectin mRNA were significantly lower in obese cats than normal cats. However, there was no difference in the expression of feline leptin between normal and obese cats. On the other hand, in both normal and obese cats, there were no significant differences in resistin, leptin and adiponectin mRNA levels between subcutaneous and visceral adipose tissues. In cats, the altered expression of resistin and adiponectin mRNA with obesity may contribute to the pathogenesis of insulin resistance and subsequent diabetes mellitus. In addition to feline adiponectin, the feline resistin cDNA clone obtained in this study will be useful for further investigation of the pathogenesis of obesity in cats.