- 著者
- Nobutaka Nagano Atsuko Muranaka Ryo Nishikawa Wataru Ohwada Hidemichi Kouzu Naoyuki Kamiyama Takefumi Fujito Atsushi Mochizuki Daigo Nagahara Mitsuhiro Nakanishi Yukiko Ohkubo Shin Hisahara Satoshi Nakao Nagaaki Katoh Aki Ishikawa Akihiro Sakurai Toshiyuki Yano
- 出版者
- International Heart Journal Association
- 雑誌
- International Heart Journal (ISSN:13492365)
- 巻号頁・発行日
- vol.63, no.1, pp.168-175, 2022-01-29 (Released:2022-01-29)
- 参考文献数
- 35
- 被引用文献数
- 7
Diagnostic strategies for symptomatic transthyretin (ATTR) cardiac amyloidosis showing typical morphological features such as increased ventricular wall thickness and myocardial injury such as an elevation in serum troponin T level have been established, but those for subclinical cardiac amyloidosis are limited. In the era when effective therapies to suppress/delay progression of ATTR cardiac amyloidosis are available, early detection of cardiac involvement plays a crucial role in appropriate decision-making for treatment in TTR mutation carriers who have a family history of heart failure and death due to ATTR amyloidosis. Findings of three cases with known pathogenic transthyretin (TTR) mutations (p.Ser70Arg, p.Phe53Val, and p.Val50Met) and family histories of death for amyloidosis were presented. Two cases were asymptomatic, and a case carrying p.Phe53Val had gastrointestinal symptoms and autonomic neuropathy. Levels of plasma N-terminal fragment of pro-B-type natriuretic peptide and troponin T were within normal ranges in all cases, but results of cardiac magnetic resonance (CMR) and bone scintigraphy clearly revealed the presence of cardiac involvement in all cases, even in a case without echocardiographic abnormalities including left ventricular hypertrophy and relative apical sparing of longitudinal strain shown by two-dimensional speckle-tracking echocardiography. Electrocardiography revealed modest abnormalities including reduced R wave amplitude in V2 and a trend toward left axis deviation in all cases. In conclusion, CMR, bone scintigraphy, and electrocardiography are useful for early detection of ATTR cardiac amyloidosis in TTR mutation carriers. The role of comprehensive cardiac assessment in the early detection of cardiac amyloidosis in TTR mutation carriers is discussed.
- 著者
- Atsushi Mochizuki Takayuki Mitsunaga
- 出版者
- JAPANESE SOCIETY OF APPLIED ENTOMOLOGY AND ZOOLOGY
- 雑誌
- Applied Entomology and Zoology (ISSN:00036862)
- 巻号頁・発行日
- vol.39, no.2, pp.217-219, 2004 (Released:2004-08-25)
- 参考文献数
- 14
- 被引用文献数
- 13 13
As a part of a risk assessment of the non-target effect of the introduced green lacewing on native ecosystem, we performed a laboratory experiment to characterize the symmetry of the interspecific predation between the introduced green lacewing, Chrysoperla carnea and the native sibling species, C. nipponensis among different stages. The elder and larger larvae always ate the younger and smaller individuals, regardless of species. When the same instar and similar sized larvae were paired, almost equal predation rates between the two species was observed. Our results suggest that size was the most important factor to determine the symmetry of the interspecific predation between C. carnea and C. nipponensis. Populations of C. nipponensis will not be decreased by interspecific predation with C. carnea without extreme mass releases of C. carnea in a small arena.