- 著者
- Kensuke ORITO Asako KAWARAI-SHIMAMURA Atsushi OGAWA Atsushi NAKAMURA
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.17-0463, (Released:2017-10-31)
- 被引用文献数
- 8
A prospective observational study was performed in canine clinical medicine to evaluate the emetic action and adverse effects of tranexamic acid. Veterinarians treated 137 dogs with a single dose of tranexamic acid (50 mg/kg, IV) after accidental ingestion of foreign substances. If needed, a second (median, 50 mg/kg; range, 20–50 mg/kg, IV) or third dose (median, 50 mg/kg; range, 25–50 mg/kg, IV) was administered. Tranexamic acid induced emesis in 116 of 137 (84.7%) dogs. Median time to onset of emesis was 116.5 sec (range, 26–370 sec), median duration of emesis was 151.5 sec (range, 30–780 sec), and median number of emesis episodes was 2 (range, 1–8). Second and third administrations of tranexamic acid induced emesis in 64.7% and 66.7% of dogs, respectively. In total, IV administration of tranexamic acid successfully induced emesis in 129 of 137 (94.2%) dogs. Adverse effects included a tonic-clonic convulsion and hemostatic disorder in two different dogs, both of which recovered after receiving medical care. Tranexamic acid induced emesis in most dogs following a single-dose. When a single dose was not sufficient, an additional dosage effectively induced emesis. Overall, adverse effects were considered low and self-limiting.
- 著者
- 松本 佳代 山本 京子 唐沢 康子 日野 徳子 中村 厚 高橋 真介 荒木 博陽 奥山 茂 町支 臣成 杉野 栄一 日比野 俐 吉本 真 マツモト カヨ ヤマモト キョウコ カラサワ ヤスコ ヒノ ノリコ ナカムラ アツシ タカハシ マサヤシ アラキ ヒロアキ オクヤマ シゲル チョウシ トミナリ スギノ エイイチ ヒビノ サトシ ヨシモト マコト Kayo Matsumoto Kyoko Yamamoto Yasuko Karasawa Noriko Hino Atsushi Nakamura Masayashi Takahashi Hiroaki Araki Shigeru Okuyama Tominari Choshi Eiichi Sugino Satoshi Hibino Makoto Yoshimoto
- 雑誌
- 福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University
- 巻号頁・発行日
- vol.22, pp.40-41, 2004
- 著者
- Kensuke ORITO Asako KAWARAI-SHIMAMURA Atsushi OGAWA Atsushi NAKAMURA
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.79, no.12, pp.1978-1982, 2017 (Released:2017-12-22)
- 参考文献数
- 22
- 被引用文献数
- 8
A prospective observational study was performed in canine clinical medicine to evaluate the emetic action and adverse effects of tranexamic acid. Veterinarians treated 137 dogs with a single dose of tranexamic acid (50 mg/kg, IV) after accidental ingestion of foreign substances. If needed, a second (median, 50 mg/kg; range, 20–50 mg/kg, IV) or third dose (median, 50 mg/kg; range, 25–50 mg/kg, IV) was administered. Tranexamic acid induced emesis in 116 of 137 (84.7%) dogs. Median time to onset of emesis was 116.5 sec (range, 26–370 sec), median duration of emesis was 151.5 sec (range, 30–780 sec), and median number of emesis episodes was 2 (range, 1–8). Second and third administrations of tranexamic acid induced emesis in 64.7 and 66.7% of dogs, respectively. In total, IV administration of tranexamic acid successfully induced emesis in 129 of 137 (94.2%) dogs. Adverse effects included a tonic-clonic convulsion and hemostatic disorder in two different dogs, both of which recovered after receiving medical care. Tranexamic acid induced emesis in most dogs following a single-dose. When a single dose was not sufficient, an additional dosage effectively induced emesis. Overall, adverse effects were considered low and self-limiting.
- 著者
- Hidenori Sakuma Atsushi Nakamura Yumi Fukuoka Mitsukuni Okabe Kunio Tsurumi Motoo Yokoi
- 出版者
- 特定非営利活動法人 日本口腔科学会
- 雑誌
- Oral Science International (ISSN:13488643)
- 巻号頁・発行日
- vol.5, no.2, pp.146-149, 2008 (Released:2008-12-08)
- 参考文献数
- 11
Septic pulmonary embolism is a rare condition, the common sources of which are bacterial endocarditis and infected venous catheters. Septic pulmonary embolism ascribed to dental infection is extremely rare. The present report describes a case of septic pulmonary embolism attributed to periapical periodontitis in a 39-year-old patient, who was admitted with persistent toothache, fever, and chest pain. Chest CT showed a feeding vessel sign and a target sign. A panoramic radiograph of the left maxillary bone showed alveolar bone loss in a horizontal pattern typical of periodontitis and periapical periodontitis. The patient was treated with intravenous antibiotics and teeth extraction. To our knowledge, only 4 cases of septic pulmonary embolism ascribed to dental infection have been reported in the English literature. These patients repeatedly developed dental infections but did not receive appropriate dental treatment including extraction of the causative teeth, leading to the development of septic pulmonary embolism. This paper may contribute to the limited clinical knowledge base regarding septic pulmonary embolism ascribed to periapical periodontitis. Effective oral care and removal of the primary source of infection, including extraction of the causative teeth, are important to prevent septic pulmonary embolism.