著者
田坂 祐一 田中 亮裕 井門 敬子 田中 守 荒木 博陽
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.40, no.4, pp.208-214, 2014-04-10 (Released:2015-04-10)
参考文献数
7
被引用文献数
4 or 0

Pharmacists have increased the provision of pharmaceutical care services to patients. However, the financial benefit of various pharmaceutical interventions has not been well described. In this study, we estimated the original economic impact associated with pharmaceutical interventions by an evidenced-based approach.We classified pharmaceutical interventions into 12 items, which included preventions of serious adverse drug reactions (ADRs), and avoidance of drug interaction. The cost saving associated with preventions of serious ADRs was calculated as ¥2,140,000 per case based on the amount of costs that were paid by the Pharmaceuticals and Medical Devices Agency. Interventions to transvenous antimicrobial therapy were estimated to have a cost saving of ¥190,000 per case based on the literature in Japan. The rates of preventing serious ADRs related to chemotherapy orders, high-risk drugs and others were 5.21%, 3.91% and 2.6%, respectively, based on the literature in the United States. Using this rate, the values of intervention related to chemotherapy orders, high-risk drugs and others were ¥112,000, ¥84,000 and ¥56,000, respectively.The number of interventions was 209 per year, including 3 avoidances of serious ADRs. According to the number of interventions, we calculated that the total cost saving associated with pharmaceutical interventions was ¥22,816,000.This is the first study to estimate the economic impact associated with various pharmaceutical interventions of pharmacists in Japan. Evaluating the economic impact in relation to the pharmaceutical interventions is an important method for assessing the role of pharmacists.
著者
谷口 律子 錦織 淳美 川崎 博己 黒崎 勇二 荒木 博陽 五味 田裕
出版者
日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.30, no.4, pp.246-254, 2004-04-10
参考文献数
9
被引用文献数
12 or 0

It is important for students to acquire the skills of pharmaceutical care with respect to patients. However, clinical pharmacy education in Japan is still not fully developed and teachers at faculties of pharmacy generally teach students by means of lectures, which is too passive for students. Since such a lecture-based system will not help them to acquire pharmaceutical care skills, there should also be training that simulates the provision of pharmaceutical care in the clinical situation. To address this issue, the authors tested problem-based learning (PEL) on students, with the objective of developing problem solving skills and student independence. In the PEL, students gained an understanding of the principles of pharmacotherapy and drew up hypothetical schemes for pharmaceutical care, worked out the problems and discussed them together in small groups. They also practiced role-playing, which was intended to help them learn communication skills. Afterwards, the authors conducted a questionnaire survey to evaluate the student's impressions of the PEL and they evaluated it highly, particularly with regard to learning communication and problem-solving skills. These results suggest that it would be useful to introduce PEL in clinical pharmacy education in Japan.
著者
鴻海 俊太郎 末丸 克矢 川崎 博己 町支 臣成 日比野 俐 荒木 博陽
出版者
公益社団法人日本薬学会
雑誌
藥學雜誌 (ISSN:00316903)
巻号頁・発行日
vol.129, no.2, pp.197-201, 2009-02-01

The rate of smoking in patients with schizophrenia is higher than that in the general population. Nicotinic acetylcholine receptors (nAChR) are involved in the sensorimotor gating deficits in schizophrenia. We have revealed that nicotine ameliorates the disruption of the PPI, a model of sensorimotor gating, which is induced by apomorphine, a dopamine receptor agonist, but is not effective for the disruption of the PPI induced by phencyclidine, a glutamine NMDA receptor antagonist, in rats. Furthermore, the ameliorating effect of nicotine is antagonized by methyllycaconitine, a selective α_7 nAChR antagonist. The effect of nocitine was also investigated in the stereotyped behavior induced by apomorphine, however, nicotine was found to have no significant effect. Considering these results, the ameliorating effect of the disruption of the PPI via α_7 nAChR is therefore thought to be involved in dopaminergic systems. The dopaminergic systems involved in α_7 nAChR may be different from the systems involved in stereotypy. In addition, this review describes the effects of the α_7 nicotinic receptor agonists.
著者
田中 守 末丸 克矢 荒木 博陽
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.33, no.4, pp.318-323, 2007 (Released:2008-06-30)
参考文献数
11
被引用文献数
3 or 2

Evidence-based medicine (EBM) is considered to be an important approach in making clinical decisions regarding the care of individual patients. We conducted a drug information training program applying EBM principles (EBM practice) as part of the hospital practical training curriculum for fourth-year undergraduates at Ehime University Medical School, and describe the EBM practice and its evaluation by students in the present report. In the EBM practice, students received two lectures and training on providing drug information using the EBM approach. We gave students a specific question, which required them to read clinical research articles (meta-analysis or randomized controlled study) in order to answer it.The training program consisted of 5 steps : STEP 1 Defining the specific question that needs to be answered ; STEP 2 Finding the best evidence to answer the question ; STEP 3 Critically evaluating the evidence to assess its validity and usefulness ; STEP 4 Applying the results of the critical evaluation in practice ; STEP 5 Presentation of drug information and discussion.After the training, we asked participating students to complete a questionnaire regarding their opinions of the training program and lectures. Almost all of the students felt satisfied with the EBM practice because it enabled them to enhance their understanding of the EBM process. Our findings suggested that the EBM practice was a useful training program for students.
著者
岡井 彰男 五十崎 俊介 山口 巧 田中 守 池川 嘉郎 末丸 克矢 荒木 博陽
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.30, no.1, pp.27-30, 2004-01-10 (Released:2011-03-04)
参考文献数
8

Triclofos sodium syrup (Tricloryl® syrup) is mainly used for pretreatment in EEG examinations and sedation before CT and MRI. The unpleasant taste of the syrup, however, occasionally causes compliance problems with children. As we had also experienced difficulties in obtaining sufficient supplies of this medicine for a few months, we prepared a chloral hydrate syrup in our hospital as a substitute for triclofos sodium syrup, aiming to reduce the unpleasant taste and smell of chloral hydrate in the process. Stability and sterility were also investigated. The results of a taste test in healthy volunteers showed that the taste and smell of a 4% chloral hydrate syrup were improved by using an apple flavor, aspartame and a simple syrup base. In our stability and sterility study under the storage condition of 4°C with shading over 6 months, the potency of the syrup was maintained (95 %) and there was no bacterial contamination. These results suggest that the 4% chloral hydrate syrup prepared in our hospital as a substitute for triclofos sodium syrup could improve the compliance of children.
著者
武市 佳己 末丸 克矢 井門 敬子 山下 梨沙子 天野 学 町田 仁 宮岡 弘明 池田 富士子 大澤 春彦 牧野 英一 荒木 博陽
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.35, no.9, pp.629-635, 2009

It has been reported that earthquakes tend to aggravate the physical and mental conditions of diabetic patients in particular due to interruption of their medication and perhaps tremendous deterioration in their living conditions as well.In this study,we conducted a survey of diabetic patients concerning their preparedness for earthquakes at three hospitals in Ehime Prefecture.The results indicated that many diabetic patients did not have a sufficient supply of emergency medicines in the event of such a disaster.In addition,many seemed to be unaware of the names of the medicines that they were taking.Based on these results and previous findings,we prepared"The Disaster Preparedness Guide for Patients with Diabetes" which includes information on medication,food,and ways of monitoring their health.The printed manual was distributed to hospitals in Ehime Prefecture and the PDF file of it was uploaded to the website of Ehime University Hospital.Afterwards,we conducted an anonymous survey of diabetic patients and medical staff concerning this material.Most respondents considered our guide to be useful for learning about disaster preparations.These findings suggest that it is necessary for medical staff to educate diabetic patients adequately concerning disaster preparations.
著者
末丸 克矢 山下 梨沙子 武市 佳己 山口 巧 公平 恵崇 岡本 千恵 五十崎 俊介 井門 敬子 田中 守 三好 裕二 守口 淑秀 池川 嘉郎 荒木 博陽
出版者
日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.32, no.2, pp.139-145, 2006
参考文献数
8
被引用文献数
11 or 0

We have been conducting a four-week practical hospital training course incorporating experience-oriented programs for fourth-year undergraduate students at Ehime University Hospital. There are 17 such programs in the curriculum among them instruction in the self-administration of insulin and bronchial asthma inhalers, nutrition support, drug counseling training using case-based learning procedures and role-play practice (CBL practice), and evidence based medicine (EBM practice) based on the provision of drug information. Self-learning exercises were devised for CBL and EBM practices. At the end of the practical hospital training course, we conducted a questionnaire survey concerning understandability, extent of previous understanding, training time, necessity of each program and degree of satisfaction with it. Analysis of the responses showed that student satisfaction with the practical training program was positively and significantly correlated with understandability (r=0.756, p<0.01) and degree of experience received (r=0.538, p<0.05). However, there was no correlation between satisfaction and previous understanding, training time or necessity. These results suggest that the experience-oriented programs enhanced students' understanding of the hospital practical training and also increased their satisfaction with it.
著者
北村 佳久 荒木 博陽 五味田 裕
出版者
公益社団法人 日本薬理学会
雑誌
日本薬理学雑誌 (ISSN:00155691)
巻号頁・発行日
vol.119, no.6, pp.319-325, 2002 (Released:2003-01-21)
参考文献数
42
被引用文献数
4 or 0

従来よりうつ病の発症機序についてはモノアミン欠乏説,受容体感受性亢進説などが提唱されてきた.しかし,これらの仮説には矛盾する点も多く,現在においても明確な発症機序についての結論はない.一方,うつ病は中枢神経系の異常のみならず視床下部-下垂体-副腎(hypothalamic-pituitary-adrenal:HPA)系の機能異常を含む中枢神経系-内分泌系の機能異常が深く関与しているといわれている.本稿では抗うつ薬の作用機序およびうつ病の病態に深く関与しているserotonin(5-HT)-HPA系の相互作用とうつ病との関連性について紹介する.動物に反復のストレス負荷およびHPA系の活性化により5-HT2受容体機能は亢進し,うつ病の病態との類似性が考えられる.ACTH反復投与によるHPA系過活動モデルではイミプラミン反復投与による5-HT2受容体ダウンレギュレーションが消失し,さらに抗うつ薬スクリーニングモデルである強制水泳法におけるイミプラミンの不動時間短縮作用も抑制される.つまり,HPA系過活動モデルは三環系抗うつ薬治療抵抗性うつ病の動物モデルとしての可能性が考えられる.これまでコルチコイド受容体や5-HT受容体サブタイプの神経化学的および分子生物学的研究は進んでいるが,今後トランスジェニックマウスまたはノックアウトマウスなどを応用し,行動薬理学的研究および神経科学的研究によりうつ病の病態メカニズムおよび抗うつ薬作用機序の解明などの重要性が増すと思われる.
著者
三好 淳子 井門 敬子 松岡 綾 武市 佳己 山口 巧 岡本 千恵 末丸 克矢 荒木 博陽
出版者
日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.31, no.3, pp.233-237, 2005-03-10
被引用文献数
10 or 0

At the Division of Pharmacy in Ehime University Hospital, we conduct drug counseling training for undergraduate students and graduate students aimed at helping them acquire communication skills as well as clinical knowledge. The program relies largely on case-based learning (CBL) procedures and role-play practice using video tape recordings. In the following, we describe the drug counseling training program and report the results of a student evaluation of the program. The training program consists of the following : 1. Explanation of the procedure of the practical training; 2. Presentation of a mock case file-including a patient profile, diagnosis, clinical history, laboratory data and prescription; 3. Explanation of how to collect drug information; 4. Study of individual cases by students, 5. Role-play in providing drug counseling and recording this on video (with a student in the counseling role and a pharmacist in the patient role) and 6. Discussion and review by students and clinical pharmacists (including the person who played the patient role) after watching the video recording. After the training, we conducted a survey of the participating students by questionnaire regarding their opinions of the training program. Almost all of the students considered the practical training to be useful because it enabled them to evaluate their performance in drug counseling and communication skills objectively. They also felt that the guidance they had received from clinical pharmacists had been useful. Our training program on drug counseling using CBL procedures and video recordings is thus a simple method of training students which enables them to improve both their communication skills and clinical knowledge.
著者
川上 英治 二神 幸次郎 定金 典明 西原 茂樹 荒木 博陽 川崎 博巳 五味田 裕
出版者
日本医療薬学会
雑誌
病院薬学 = Journal of the Nippon Hospital Pharmacists Association (ISSN:03899098)
巻号頁・発行日
vol.25, no.1, pp.69-75, 1999-02-10
被引用文献数
8 or 0

Pharmacists need to have a clear policy for managing investigational drugs under circumstances that are consistent with Good Clinical Practice. We studied the management and support system for the clinical research of investigational drugs based on the management of investigational drugs. We experienced 126 cases of pharmaceutical consultations in 650 prescriptions for investigational drugs from April 1997 to March 1998. Seven cases which might induce a patient to drop out, were included in pharmaceutical consultations. We found it was important to communicate with all investigators regarding giving adequate prior information to having a clearly defined protocol. Our pharmaceutical program for the clinical research of investigational drugs was thus found to be useful in the management of investigational drugs.
著者
山口 巧 堀尾 郁夫 青木 亮太 山下 登 田中 守 出石 文男 宮内 芳郎 荒木 博陽
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.133, no.11, pp.1249-1259, 2013 (Released:2013-11-01)
参考文献数
17
被引用文献数
1 or 0

In 2009, the Japan Anti-Doping Agency (JADA) established Sports Pharmacist—a system for certified pharmacists. There are many over-the-counter drugs that contain prohibited substances in Japan, and they are easily available. In Japan, most doping violations are committed when athletes unintentionally take prohibited substances. Therefore, the Sports Pharmacist has a vital role in promoting the prevention of doping. In the present study, surveys involving a total of 350 athletes, (including 260 representatives of Ehime Prefecture in the National Athletic Meets and 90 college students who participated in the intercollegiate athletics Shikoku area meets), on awareness regarding doping and medical drugs were conducted. Using correspondence and logistic regression analyses, the results were examined to develop a model for the prediction of athletes' actions to cope with sickness based on changes in their awareness of anti-doping, and the relationship between them was also analyzed. The survey results suggested that attitudes towards doping were strongly influenced by gender, rather than the athletic ability and whether or not a doping test is scheduled. Their behavior and criteria for the selection of drugs to address sickness were strongly correlated with awareness of anti-doping. Therefore, athletes with an increased awareness of anti-doping are expected to consult a pharmacist prior to using medicine. The Sports Pharmacist should further promote environmental development, such as activities to improve awareness of doping among young athletes and the establishment of medical drug consultation services for athletes (female athletes in particular).