著者

David G. Goodman Masanori Miyazawa

出版者

Lexington Books

巻号頁・発行日

2000

著者

Lin Y. Chen David G. Benditt Alvaro Alonso

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-14-0814, (Released:2014-09-26)

参考文献数

36

被引用文献数

5 44

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Evidence is emerging to indicate that atrial fibrillation (AF) is independently associated with an increased risk of sudden cardiac death (SCD). This association has been consistently observed in specific patient subgroups such as patients with myocardial infarction (MI), heart failure, and hypertension, and importantly, in the general population. Data from studies of implantable cardioverter-defibrillator recipients suggest that the rapid and irregular rhythm of AF and the short-long-short cycles that are highly prevalent in AF increase susceptibility to ventricular tachycardia and ventricular fibrillation. An alternative explanation for the association between AF and SCD includes confounding or mediation by shared risk factors such as coronary artery disease and heart failure. Possible risk factors for SCD in patients with AF include black race, left ventricular hypertrophy, history of MI, and diabetes. Additional research is needed to confirm the inherent proarrhythmic nature of AF, identify patients’ characteristics or clinical conditions that potentiate SCD risk, and define effective SCD prevention strategies for patients with AF.

著者

edited by David G. Stern Brian Rogers and Gabriel Citron

出版者

Cambridge University Press

巻号頁・発行日

2016

著者

Sirada Boonyaketgoson Yongle Du Ana L. Valenciano Murillo Maria B. Cassera David G. I. Kingston Kongkiat Trisuwan

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.68, no.7, pp.671-674, 2020-07-01 (Released:2020-07-01)

参考文献数

17

被引用文献数

4

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Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2–12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 with IC50 values of 36.7 and 33.9 µM, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 µM. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 µM.

著者

Senshi Fukashiro Thor F. Besier Rod Barrett Jodie Cochrane Akinori Nagano David G. Lloyd

出版者

Japan Society of Physical Education, Health and Sport Sciences

雑誌

International Journal of Sport and Health Science (ISSN:13481509)

巻号頁・発行日

vol.3, no.Special_Issue_2005, pp.272-279, 2005 (Released:2008-01-23)

参考文献数

29

被引用文献数

22 36

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The purpose of this study was to perform a detailed kinematic, kinetic, and electromyographic comparison of maximal effort horizontal and vertical jumping. It was of particular interest to identify factors responsible for the control of jump direction. Eight male subjects performed maximal horizontal jumps (HJ) and vertical jumps (VJ) from a standing posture with a counter movement. Three-dimensional motion of the trunk, pelvis, and bilateral thigh, shank, and foot segments were recorded together with bilateral ground reaction forces and electromyographic (EMG) activity from seven right leg muscles. Relative to the VJ, the trunk is displaced further forward at the beginning of the HJ, through greater ankle joint dorsiflexion and knee extension. The activity of the biarticular rectus femoris and hamstrings were adapted to jump direction and helped to tune the hip and knee joint torques to the requirements of the task. The primary difference in joint torques between the two jumps was for the knee joint, with the extension moment reduced in the HJ, consistent with differences in activation levels of the biarticular rectus femoris and hamstrings. Activity of the mono-articular knee extensors was adapted to jump direction in terms of timing rather than peak amplitude. Overall results of this study suggest that jump direction is controlled by a combination of trunk orientation at the beginning of the push-off and the relative activation levels of the biarticular rectus femoris and hamstring muscles during the push-off.

著者

DAVID G. MARTIN CAROLYN BILES SHIRLEY A. GERPHEIDE LADISLAV J. HANKA WILLIAM C. KRUEGER J. PATRICK MCGOVREN STEPHEN A. MIZSAK GARY L. NEIL JULIANNA C. STEWART JERONIMO VISSER

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.34, no.9, pp.1119-1125, 1981 (Released:2006-04-12)

参考文献数

8

被引用文献数

80 104

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( Received for publication June 15, 1981)CC-1065 (NSC 298223) is a potent new antitumor antibiotic with a unique structure produced by Streptomyces zelensis. Improved production, isolation, and assay methods are described along with physico-chemical properties and antitumor activity.

著者

菅原 徹 David G. CORK

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.55, no.5, pp.466-473, 1997-05-01 (Released:2009-11-16)

参考文献数

38

被引用文献数

3 4

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Organic synthetic chemistry utilises scientific technology from various fields but compared to the great advances seen in the automation of analytical instruments over the last 20 years, the synthesis of organic compounds has been relatively slow to move from a largely manual process. Automation of synthesis is not only important for increasing efficiency, precision and safety but also decreasing labor and exploring new synthetic methodologies. In this review of automated synthesis apparatus we broadly divide them into two categories;those using robotic transfer of a reagent, reactant, product or vessel, and others that only use flow-lines for transfers between fixed reactors. These categories are then sub-divided into systems and workstations according to the extent of the operations and functions. We highlight some of the representative past and present automated synthesis apparatus and look at what the future may hold in the way of miniaturized and high-throughput automated synthesis.

著者

Victor David G.

出版者

フォーリン・アフェアーズ・ジャパン

雑誌

フォーリン・アフェアーズ (ISSN:18808786)

巻号頁・発行日

vol.2007, no.8, pp.127-143, 2007-08